Results 51 to 60 of about 15,817,770 (195)

EFFECTS OF THE S-ADENOSYLHOMOCYSTEINE HYDROLASE INHIBITORS 3-DEAZAADENOSINE AND 3-DEAZAARISTEROMYCIN ON RNA METHYLATION AND SYNTHESIS [PDF]

, 1986
The effects of 3-deazaaristeromycin and 3-deazaadenosine on RNA methylation and synthesis were examined in the mouse macrophage cell line, RAW264.
Peter S. Backlund, Giulio L. Cantoni, CAROTTI, Daniela, Daniela CAROTTI   +3 more
core   +1 more source

Blockade of the trans-sulfuration pathway in acute pancreatitis due to nitration of cystathionine β-synthase

Redox Biology, 2020
Acute pancreatitis is an inflammatory process of the pancreatic gland that may lead to dysregulation of the trans-sulfuration pathway. The aims of this work were firstly to study the methionine cycle as well as the trans-sulfuration pathway using ...
Sergio Rius-Pérez, Salvador Pérez, Isabel Torres-Cuevas, Pablo Martí-Andrés, Raquel Taléns-Visconti, Alberto Paradela, Laura Guerrero, Luis Franco, Gerardo López-Rodas, Luis Torres, Fernando Corrales, Juan Sastre   +11 more
doaj   +1 more source

Nitric oxide modulates folate-mediated one-carbon metabolism and mitochondrial energy levels of peaches during cold storage

Frontiers in Nutrition, 2023
Folate-mediated one-carbon metabolism (FOCM) is closely associated with postharvest preservation. This study investigated the effects of exogenous nitric oxide (NO) on FOCM, storage quality, energy metabolism, and mitochondrial membrane integrity in cold-
Zhifeng Yang, Shuhua Zhu, Shuhua Zhu, Xiaoyu Wang, Changbao Chen, Dandan Huang, Jianrong Feng   +6 more
doaj   +1 more source

S-Adenosylhomocysteine Metabolism in Rat Hepatomas

Experimental Biology and Medicine, 1978
SummaryS-Adenosylhomocysteine synthase was present in extracts prepared from six lines of rat hepatoma. There was no apparent correlation between the specific activity of this enzyme and any of the other biological properties of the tumors. The presence of the hepatoma did not affect the activity of adenosylhomocysteine synthase in livers of host ...
J D, Finkelstein, B J, Harris, M R, Grossman, H P, Morris   +3 more
openaire   +2 more sources

S-adenosylhomocysteine hydrolase and adenosine deaminase activities in human red cell ageing. [PDF]

, 1990
The enzyme activities of S-adenosylhomocysteine hydrolase, adenosine deaminase and pyruvate kinase were determined in normal human erythrocytes subpopulations of different ages separated by centrifugation on a discontinuous Percoll:NaCl density gradient.
B. Furciniti La Chiusa, STROM, Roberto, CRIFO', Carlo, BOZZI, Argante   +3 more
core   +1 more source

Truncated fluorocyclopentenyl pyrimidines as S-adenosylhomocysteine hydrolase inhibitors [PDF]

, 2020
On the basis of inhibitory activity of truncated cyclopentenyl cytosine against S-adenosylhomocysteine hydrolase (SAH), its fluorocyclopentenyl pyrimidine derivatives were efficiently synthesized from D-ribose via electrophilic fluorination as a key step.
최원준, 이강만, 정낙신
core   +1 more source

Comprehensive transcriptomics and metabolomics analyses reveal that hyperhomocysteinemia is a high risk factor for coronary artery disease in a chinese obese population aged 40–65: a prospective cross-sectional study

Cardiovascular Diabetology, 2023
Background Clinical observations suggest a complex relationship between obesity and coronary artery disease (CAD). This study aimed to characterize the intermediate metabolism phenotypes among obese patients with CAD and without CAD.
Chong-Yu Zhang, Ru-Qin Xu, Xiao-Qiao Wang, Lin-Feng Sun, Pei Mo, Ren-Jie Cai, Xiao-Zhen Lin, Cheng-Feng Luo, Wen-Chao Ou, Lie-Jing Lu, Yun Zhong, Jia-Yuan Chen   +11 more
doaj   +1 more source

The expression of SAH, IL-1β, Hcy, TNF-α and BDNF in coronary heart disease and its relationship with the severity of coronary stenosis

BMC Cardiovascular Disorders, 2022
Background To investigate the expression of serum S-adenosylhomocysteine (SAH), interleukin-1β (IL-1β), serum homocysteine (Hcy), tumor necrosis factor-α (TNF-α) and brain derived neurotrophic factor (BDNF) in coronary heart disease and their ...
You Wu, Lin Wang, Yu Zhan, Zhixin Zhang, Dan Chen, Yang Xiang, Cui Xie   +6 more
doaj   +1 more source

DNA methylation changes underlie the long-term association between periodontitis and atherosclerotic cardiovascular disease

Frontiers in Cardiovascular Medicine, 2023
Periodontitis, the leading cause of adult tooth loss, has been identified as an independent risk factor for cardiovascular disease (CVD). Studies suggest that periodontitis, like other CVD risk factors, shows the persistence of increased CVD risk even ...
Mohamed Omar, Maria Alexiou, Umar R. Rekhi, Konrad Lehmann, Aneesh Bhardwaj, Cole Delyea, Shokrollah Elahi, Maria Febbraio   +7 more
doaj   +1 more source

Inhibition of sterol transmethylation by S-adenosylhomocysteine analogs [PDF]

Journal of Bacteriology, 1981
Structural analogs of S-adenosylhomocysteine were tested in vitro for inhibition of the yeast S-adenosylmethionine:delta 24-sterol-C-methyltransferase enzyme. A wide inhibitory range by these compounds was observed, suggesting which structural features of the parent compound are important for binding to the enzyme.
M T, McCammon, L W, Parks
openaire   +2 more sources