Results 61 to 70 of about 15,817,770 (195)

Stereoselective synthesis of homo-apioneplanocin A as potential inhibitor of S-adenosylhomocysteine hydrolase [PDF]

, 2018
Homo-apioneplanocin A (1) as a potential inhibitor of S- adenosylhomocysteine hydrolase was synthesized from D-ribose, employing stereoselective hydroxymethylation, regioselective oxidation, and regio- and chemoselective hydroboration as key steps ...
이강만, 정낙신
core   +1 more source

Plasma homocysteine and liver tissue S-adenosylmethionine, S-adenosylhomocysteine status in vitamin B-6-deficient rats [PDF]

, 2015
OBJECTIVE: The aim of this study was to evaluate plasma homocysteine (Hcy), malondialdehyde (MDA), glutathione (GSH) levels, glutathione peroxidase (GSH-Px) and glutathione-S-transferase (GST) activities and liver tissue S-adenosylmethionine (SAM) and S ...
Taysi, S., Gumustekin, K., Bakan, N., Boyuk, A., Akyuz, M., Keles, M. S., Cikman, O.   +6 more
core   +3 more sources

Combined Immunodeficiency Manifests from S-Adenosylhomocysteine (SAH) Hydrolase Deficiency

Journal of Human Immunity
S-adenosylhomocysteine (SAH) hydrolase deficiency is a rare autosomal recessive disorder caused by pathogenic variants of the gene AHCY. Loss of SAH hydrolase causes SAH accumulation and impairs the methionine/S-adenosylmethionine (SAM) cycle that is ...
Ian Cohn, Dara Bakar, Kierstin Keller, Francis Jeshira Reynoso, Di Sun   +4 more
doaj   +1 more source

Reduction of Ribonucleotide Reductase Subunit RRM2 Potentially Impairs Gut Function of Woody Breast Broilers

Animal Research and One Health, EarlyView.
Woody breast compromises meat quality leading to reduced consumer appeal. Although its causes are unclear, improvements observed with certain dietary supplements suggest that gut health may influence woody breast development. Ribonucleotide reductase subunit RRM2 is vital for mitochondrial function and gastrointestinal integrity, and alteration in its ...
Majid Shakeri, Elizabeth Ziabtchenko, Janghan Choi, Caitlin E. Harris, Richard J. Buhr, Trevor R. Mitchell, Byungwhi Kong, Hong Zhuang, Brian Bowker   +8 more
wiley   +1 more source

Stereoselective synthesis of a novel apio analogue of neplanocin A as potential S-adenosylhomocysteine hydrolase inhibitor [PDF]

, 2018
(matrix presented) A total synthesis of apio-neplanocin A, which combines properties of apio nucleoside and neplanocin A and is a potencial inhibitor of S-adenosylhomocysteine hydrolase, ws accomplished starting from D-ribose via stereoselective ...
이강만, 정낙신
core   +1 more source

Localization of S-adenosylhomocysteine Hydrolase in the Rat Kidney [PDF]

Journal of Histochemistry & Cytochemistry, 2000
S-adenosylhomocysteine (SAH) hydrolase is a cytosolic enzyme present in the kidney. Enzyme activities of SAH hydrolase were measured in the kidney in isolated glomeruli and tubules. SAH hydrolase activity was 0.62 ± 0.02 mU/mg in the kidney, 0.32 ± 0.03 mU/mg in the glomeruli, and 0.50 ± 0.02 mU/mg in isolated tubules. Using immunohistochemical methods,
D, Kloor, W, Stumvoll, H, Schmid, J, Kömpf, A, Mack, H, Osswald   +5 more
openaire   +2 more sources

Metabolic abnormalities and reprogramming in cats with naturally occurring hypertrophic cardiomyopathy

ESC Heart Failure, Volume 12, Issue 2, Page 1256-1270, April 2025.
Abstract Background and aims The heart is a metabolic organ rich in mitochondria. The failing heart reprograms to utilize different energy substrates, which increase its oxygen consumption. These adaptive changes contribute to increased oxidative stress.
Qinghong Li, Max Homilius, Erin Achilles, Laura K. Massey, Victoria Convey, Åsa Ohlsson, Ingrid Ljungvall, Jens Häggström, Brittany Vester Boler, Pascal Steiner, Sharlene Day, Calum A. MacRae, Mark A. Oyama   +12 more
wiley   +1 more source

Distribution of S-Adenosylhomocysteine Hydrolase, S-Adenosylhomocysteine Nucleosidase, S-Ribosylhomocysteine Cleavage Enzyme and Homoserine Dehydratase in Various Species [PDF]

, 1973
Microorganisms, plants and the major organs from cold and warm blooded vertebrates ware assayed for the presence of S-adenosylhomocysteine hydrolase, S-adenosylhomocysteine nucleosidase, S-ribosylhomocysteine cleavage enzyme and homoserine dehydratase. S-
Walker, Robert D.
core   +1 more source

The mPlrp2 and mClps genes are involved in the hydrolysis of retinyl esters in the mouse liver[S]

Journal of Lipid Research, 2011
Retinyl esters are the major chemical forms of vitamin A stored in the liver, and can be delivered to peripheral tissues for conversion into biologically active forms.
Wenqiang Pang, Ying Zhang, Shiming Wang, Aiqun Jia, Wei Dong, Chun Cai, Zichun Hua, Jianfa Zhang   +7 more
doaj   +1 more source

Antiparasitic activity of FLLL-32 against four Babesia species, B. bovis, B. bigemina, B. divergens and B. caballi, and one Theileria species, Theileria equi in vitro, and Babesia microti in mice

Frontiers in Pharmacology, 2023
Introduction: FLLL-32, a synthetic analog of curcumin, is a potent inhibitor of STAT3’s constitutive activation in a variety of cancer cells, and its anticancer properties have been demonstrated both in vitro and in vivo.
Shimaa Abd El-Salam El-Sayed, Shimaa Abd El-Salam El-Sayed, El-Sayed El-Alfy, Hanadi B. Baghdadi, Hanadi B. Baghdadi, Mohamed Z. Sayed-Ahmed, Saad S. Alqahtani, Nawazish Alam, Sarfaraz Ahmad, Md. Sajid Ali, Ikuo Igarashi, Mohamed Abdo Rizk   +11 more
doaj   +1 more source