Results 1 to 10 of about 60,031 (297)

Associations of S-Adenosylmethionine and S-Adenosylhomocysteine with Hepatocellular Carcinoma. [PDF]

Metabolites
Background: Hepatocellular carcinoma (HCC) is a leading cause of cancer-related deaths worldwide, increasingly arising in patients with metabolic dysfunction-associated steatotic liver disease (MASLD).
Yalley NN, Armasu SM, Fan WZ, Yan IK, Ahmed FY, Stål P, Roberts LR, Patel T, Antwi SO.   +8 more
europepmc   +4 more sources

Genomewide Analysis of Mode of Action of the S -Adenosylmethionine Analogue Sinefungin in Leishmania infantum

mSystems, 2019
To further our understanding of one-carbon metabolism in the protozoan parasite Leishmania, we conducted genomic screens to study how the parasite responded to sinefungin (SNF) selection.
Arijit Bhattacharya, Mansi Sharma, Charles Packianathan, Barry P. Rosen, Philippe Leprohon, Marc Ouellette   +5 more
openalex   +3 more sources

Interplay of serum taurine, S-adenosylmethionine, and cysteine levels in cancer risk: a prospective study. [PDF]

Front Pharmacol
BackgroundAmino acids are known to play critical roles in cancer metabolism and progression. Among them, taurine, S-adenosylmethionine (SAM), and cysteine have garnered particular attention due to their interconnected metabolic pathways.
Liu C, Liu T, Wei Y, Shi J, Deng L, Song M, Shi H.   +6 more
europepmc   +2 more sources

(S)-S-adenosylmethionine in the treatment of pre-menstrual disorders in adult women: A protocol for an open-label pilot study. [PDF]

Contemp Clin Trials Commun
Pre-menstrual disorders, including pre-menstrual syndrome and pre-menstrual dysphoric disorder, are highly prevalent disorders in women of reproductive age. Pre-menstrual disorders are associated with debilitating symptoms that onset in the days prior to
Stevenson B, Gavrilidis E, Malik Y, Kulkarni J.   +3 more
europepmc   +2 more sources

Cysteine Restriction Induces Ferroptosis Depending on the <i>S</i>-adenosylmethionine and Polyamine Biosynthetic Pathways in Hepatic Cancer Cells. [PDF]

Gastro Hep Adv
Background and Aims: Liver diseases such as hepatocellular carcinoma are known to be affected by nutrition and metabolic activities, but the mechanisms behind them remain unclear.
Tada K, Mitsuyama K, Nishizawa H, Shima H, Muto A, Wada M, Saigusa D, Igarashi K.   +7 more
europepmc   +2 more sources

Impact of sevoflurane anesthesia on S-adenosylmethionine in neonates under general anesthesia. [PDF]

J Anaesthesiol Clin Pharmacol
Background and Aims: Preclinical studies in rodents and primates have shown that anesthesia was neurotoxic to the developing brain after exposure in the neonatal period. Sevoflurane a commonly used inhalational anesthetic, especially in pediatric surgery,
Nagappa S, Kalappa S, Sridhara RB, Biligi DS, Annapoorneshwari R, Ramachandraiah.   +5 more
europepmc   +2 more sources

Engineered reduction of S-adenosylmethionine alters lignin in sorghum. [PDF]

Biotechnol Biofuels Bioprod
Background Lignin is an aromatic polymer deposited in secondary cell walls of higher plants to provide strength, rigidity, and hydrophobicity to vascular tissues.
Tian Y, Gao Y, Turumtay H, Turumtay EA, Chai YN, Choudhary H, Park JH, Wu CY, De Ben CM, Dalton J, Louie KB, Harwood T, Chin D, Vuu KM, Bowen BP, Shih PM, Baidoo EEK, Northen TR, Simmons BA, Hutmacher R, Atim J, Putnam DH, Scown CD, Mortimer JC, Scheller HV, Eudes A.   +25 more
europepmc   +2 more sources

S-adenosylmethionine and nicotinamide riboside therapy in Arts syndrome: A case report and literature review. [PDF]

JIMD Rep, 2023
Phospho‐ribosyl‐pyrophosphate synthetase 1 (PRPS1) deficiency is secondary to loss of function variants in PRPS1. This enzyme generates phospho‐ribosyl‐pyrophosphate (PRPP), which is utilized in the synthesis of purines, nicotinamide adenine dinucleotide
Lee A, Knox R, Reynolds M, McRoy E, Nguyen H.   +4 more
europepmc   +2 more sources

Enzymatic Cleavage of S-Adenosylmethionine

Journal of Biological Chemistry, 1959
S-adenosylmethionine, known for some time to be the biological methyl donor in mammalian enzymatic transmethylation reactions (1,2), has more recently been implicated in other transalkylation reactions in bacteria and yeast (3-6). The enzyme system catalyzing the condensation of ATP and methionine to form AMe’ has been found in a variety of tissues and
S. Harvey Mudd
openaire   +3 more sources

Aurora kinase A promotes trained immunity via regulation of endogenous S-adenosylmethionine metabolism. [PDF]

Elife
Li M, Jin H, Liu Y, Wang Z, Li L, Wang T, Wang X, Zhang H, Huo B, Yu T, Wang S, Zhao W, Liu J, Huang P, Cui J, Xia X.   +15 more
europepmc   +3 more sources