Results 1 to 10 of about 25,478 (242)
S-Adenosylmethionine in a Neuroblastoma [PDF]
Pediatric Research, 1971 Soluble extracts of a neuroblastoma did not require additional methyl donor, S-adenosyl-L-methionine (SAM), for maximal catechol O-methltransferase activity. Prior dialysis of the extract resulted in complete loss of enzymatic activity which could be partially recovered by addition of SAM to the reaction mixture.
George M. Lyon
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S-Adenosylmethionine and Pneumocystis carinii [PDF]
Journal of Biological Chemistry, 2000 We previously reported that S-adenosylmethionine (AdoMet), a key molecule in methylation reactions and polyamine biosynthesis, enhances axenic culture of the AIDS-associated opportunistic fungal pathogen Pneumocystis carinii. Here we report that AdoMet is absolutely required for continuous growth. Two transporters are present, one high affinity, K(m) =
Salim Merali +3 more
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S-adenosylmethionine metabolism and liver disease
Annals of Hepatology, 2013 Methionine is an essential amino acid that is metabolized mainly by the liver where it is converted to S-adenosylmethionine (SAMe) by the enzyme methionine adenosyltransferase.
José M. Mato +2 more
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SAMe: S-Adenosylmethionine [PDF]
American Journal of Health-System Pharmacy, 2000 Carl Salzman +2 more
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S-Adenosylmethionine and Pneumocystis [PDF]
FEMS Microbiology Letters, 2004 Pneumocystis is a parasitic fungus causing pneumonia in immunosuppressed mammals and S-adenosylmethionine a key intermediary metabolite for all cells. Other than a species of Rickettsia bacteria and an aberrant strain of the protozoan Amoeba proteus, Pneumocystis is the only cell known unable to synthesize AdoMet; it must extract this key compound from
Allen B. Clarkson, Salim Merali
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Stable Isotope Dilution Assays for Clinical Analyses of Folates and Other One-Carbon Metabolites: Application to Folate-Deficiency Studies. [PDF]
PLoS ONE, 2016 Folate deficiency is generally accepted as a potential direct or indirect risk factor for diseases including spina bifida, coronary heart diseases, malfunctions of the central nervous system, and cancer. The direct inclusion of folates in the methylation
Markus Kopp +3 more
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Characterization of a Novel Putative S-Adenosylmethionine Decarboxylase-Like Protein from Leishmania donovani. [PDF]
PLoS ONE, 2013 In addition to the S-adenosylmethionine decarboxylase (AD) present in all organisms, trypanosomatids including Leishmania spp. possess an additional copy, annotated as the putative S-adenosylmethionine decarboxylase-like proenzyme (ADL).
Saurabh Pratap Singh +2 more
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5-methyl-tetrahydrofolate and the S-adenosylmethionine cycle in C57BL/6J mouse tissues: gender differences and effects of arylamine N-acetyltransferase-1 deletion. [PDF]
PLoS ONE, 2013 Folate catabolism involves cleavage of the C(9)-N(10) bond to form p-aminobenzoylgluamate (PABG) and pterin. PABG is then acetylated by human arylamine N-acetyltransferase 1 (NAT1) before excretion in the urine.
Katey L Witham +5 more
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Metabolites, 2022 S-adenosylmethionine (SAM) is essential for methyl transfer reactions. All SAM is produced de novo via the methionine cycle. The demethylation of SAM produces S-adenosylhomocysteine (SAH), an inhibitor of methyltransferases and the precursor of ...
Aida Corrillero Bravo +12 more
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Ademethionine in the treatment of fatigue in liver diseases: a systematic review [PDF]
Терапевтический архив, 2019 Fatigue has a significant effect on the condition of patients with liver disease. Ademethionine is considered one of the most promising drugs for its treatment. Aim.
K L Raikhelson, E A Kondrashina
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