Results 141 to 150 of about 60,031 (297)

Lifespan‐Extending Endogenous Metabolites

Aging Cell, Volume 25, Issue 2, February 2026.
Endogenous metabolites act as mediators of longevity by modulating conserved cellular pathways. We summarize mechanistic evidence linking specific metabolites to lifespan and healthspan benefits across model systems, with discussion of clinical evidence, translational opportunities, and remaining knowledge gaps.
Yizhou Jiang, Jing‐Dong J. Han
wiley   +1 more source

Selection for Postponed Senescence in Drosophila melanogaster Reveals Distinct Metabolic Aging Trajectories Modifiable by the Angiotensin‐Converting Enzyme Inhibitor Lisinopril

Aging Cell, Volume 25, Issue 2, February 2026.
Assessment of oxygen consumption rates in young, middle‐aged, and old flies from the Drosophila B lines and long‐lived O lines revealed a significant increase in metabolic rate with aging only in B flies. Lisinopril prevented the age‐related rise in metabolic rate in B female flies.
Denise Vecchié, Robert R. H. Anholt, Trudy F. C. Mackay, Maria De Luca   +3 more
wiley   +1 more source

HERVs, transposons and human diseases : part 3 [PDF]

, 2012
Part 1 and 2 of this article can be found through theses links: https://www.um.edu.mt/library/oar//handle/123456789/12961 https://www.um.edu.mt/library/oar//handle/123456789/13012Part 3 of the article.
Baldacchino, Sandra, Grech, Alfred
core   +1 more source

Pharmacogenomics of Thiopurine Drugs: A Bench‐To‐Bedside Success Story in Thailand

Clinical and Translational Science, Volume 19, Issue 2, February 2026.
ABSTRACT Thiopurine drugs are the cornerstone treatment for many diseases such as acute lymphoblastic leukemia (ALL), organ rejection, inflammatory bowel disease (IBD), systemic lupus erythematosus (SLE), rheumatoid arthritis (RA) and other autoimmune diseases.
Mohitosh Biswas, Shobana John, Murshadul Alam Murad, Chonlaphat Sukasem   +3 more
wiley   +1 more source

Functional proteomics of nonalcoholic steatohepatitis: mitochondrial proteins as targets of S-adenosylmethionine [PDF]

, 2003
Recent work shows that S-adenosylmethionine (AdoMet) helps maintain normal liver function as chronic hepatic deficiency results in spontaneous development of steatohepatitis and hepatocellular carcinoma.
Avila, M.A. (Matías Antonio), Corrales, F.J. (Fernando José), Latasa, M.U. (María Ujué), Lu, S.C. (Shelly C.), Martin-Duce, A. (Antonio), Mato, J.M. (José María), Rubio, A. (Ángel), Santamaria, E. (Enrique)   +7 more
core  

A growth‐based assay using fluorescent protein emission to screen for S‐adenosylmethionine synthetase inhibitors [PDF]

, 2023
Ronald E. Viola, Gwenn G. Parungao, Robert Blumenthal   +2 more
openalex   +1 more source

Acute hepatitis and haemolysis associated with doxycycline and rifampin administration in two weanling foals

Equine Veterinary Education, Volume 38, Issue 2, Page e70-e77, February 2026.
Summary Two foals were being treated with a combination of oral doxycycline and rifampin for presumed Rhodococcus equi infections. After 3–4 weeks of antimicrobial administration, both foals presented with icterus and nonspecific clinical signs, including lethargy and inappetence.
A. Murdock, D. Wong, T. Hall, B. Sponseller, J. Howard, K. Frerichs, A. Bianco, R. Ruby   +7 more
wiley   +1 more source

Maternal Fructose Intake During Pregnancy Induced the Hepatic Glucose Homeostasis Imbalance in the Offspring by Inhibiting Glucokinase

The FASEB Journal, Volume 40, Issue 2, 31 January 2026.
Schematic diagram of the core mechanisms. The study demonstrated that maternal fructose intake during pregnancy led to glucose intolerance and insulin resistance in offspring. The abnormal hepatic glucose metabolism in offspring was associated with decreased GK expression, which was inhibited by DNMT3B.
Yahui Miao, Ziyu Meng, Shihang Chen, Xiaoyu Li, Ting Fang, Xiaoqing Deng, Bei Sun, Liming Chen   +7 more
wiley   +1 more source

S‐Adenosylmethionine in cell growth, apoptosis and liver cancer

, 2008
Shelly C. Lu, José M. Mato
openalex   +1 more source

FERONIA receptor kinase interacts with S‐adenosylmethionine synthetase and suppresses S‐adenosylmethionine production and ethylene biosynthesis in Arabidopsis [PDF]

, 2015
Dandan Mao, Feng Yu, Jian Li, Bram Van de Poel, Dan Tan, Jianglin Li, Yanqionq Liu, Xiushang Li, Meng‐Qiu Dong, Liang-Bi Chen, Dong-Ping Li, Sheng Luan   +11 more
openalex   +1 more source