Results 11 to 20 of about 60,031 (297)

Protective role of S-Adenosylmethionine against fructose-induced oxidative damage in obesity [PDF]

Journal of Mind and Medical Sciences, 2017
Introduction. It has been shown that S-adenosylmethionine (S-AMe) stimulates glutathione synthesis and increases cell resistance to the cytotoxic action of free radicals and pro-inflammatory cytokines. The aim of this study was to determine the effect of
Kameliya Zh Bratoeva, Mariya A. Radanova, Albena V. Merdzhanova, Ivan S. Donev   +3 more
doaj   +5 more sources

Structural Evidence for DUF512 as a Radical S-Adenosylmethionine Cobalamin-Binding Domain. [PDF]

ACS Bio Med Chem Au
Wang B, Solinski AE, Radle MI, Peduzzi OM, Knox HL, Cui J, Maurya RK, Yennawar NH, Booker SJ.   +8 more
europepmc   +2 more sources

Blockade of the trans-sulfuration pathway in acute pancreatitis due to nitration of cystathionine β-synthase

Redox Biology, 2020
Acute pancreatitis is an inflammatory process of the pancreatic gland that may lead to dysregulation of the trans-sulfuration pathway. The aims of this work were firstly to study the methionine cycle as well as the trans-sulfuration pathway using ...
Sergio Rius-Pérez, Salvador Pérez, Isabel Torres-Cuevas, Pablo Martí-Andrés, Raquel Taléns-Visconti, Alberto Paradela, Laura Guerrero, Luis Franco, Gerardo López-Rodas, Luis Torres, Fernando Corrales, Juan Sastre   +11 more
doaj   +1 more source

Stable Isotope Dilution Assays for Clinical Analyses of Folates and Other One-Carbon Metabolites: Application to Folate-Deficiency Studies. [PDF]

PLoS ONE, 2016
Folate deficiency is generally accepted as a potential direct or indirect risk factor for diseases including spina bifida, coronary heart diseases, malfunctions of the central nervous system, and cancer. The direct inclusion of folates in the methylation
Markus Kopp, Rosalie Morisset, Peter Koehler, Michael Rychlik   +3 more
doaj   +1 more source

Characterization of a Novel Putative S-Adenosylmethionine Decarboxylase-Like Protein from Leishmania donovani. [PDF]

PLoS ONE, 2013
In addition to the S-adenosylmethionine decarboxylase (AD) present in all organisms, trypanosomatids including Leishmania spp. possess an additional copy, annotated as the putative S-adenosylmethionine decarboxylase-like proenzyme (ADL).
Saurabh Pratap Singh, Pragati Agnihotri, J Venkatesh Pratap   +2 more
doaj   +1 more source

S-Adenosylmethionine and Pneumocystis [PDF]

FEMS Microbiology Letters, 2004
Pneumocystis is a parasitic fungus causing pneumonia in immunosuppressed mammals and S-adenosylmethionine a key intermediary metabolite for all cells. Other than a species of Rickettsia bacteria and an aberrant strain of the protozoan Amoeba proteus, Pneumocystis is the only cell known unable to synthesize AdoMet; it must extract this key compound from
Salim, Merali, Allen Boykin, Clarkson
openaire   +2 more sources

5-methyl-tetrahydrofolate and the S-adenosylmethionine cycle in C57BL/6J mouse tissues: gender differences and effects of arylamine N-acetyltransferase-1 deletion. [PDF]

PLoS ONE, 2013
Folate catabolism involves cleavage of the C(9)-N(10) bond to form p-aminobenzoylgluamate (PABG) and pterin. PABG is then acetylated by human arylamine N-acetyltransferase 1 (NAT1) before excretion in the urine.
Katey L Witham, Neville J Butcher, Kim S Sugamori, Debbie Brenneman, Denis M Grant, Rodney F Minchin   +5 more
doaj   +1 more source

Analysis of S-Adenosylmethionine and S-Adenosylhomocysteine: Method Optimisation and Profiling in Healthy Adults upon Short-Term Dietary Intervention

Metabolites, 2022
S-adenosylmethionine (SAM) is essential for methyl transfer reactions. All SAM is produced de novo via the methionine cycle. The demethylation of SAM produces S-adenosylhomocysteine (SAH), an inhibitor of methyltransferases and the precursor of ...
Aida Corrillero Bravo, Maria Nieves Ligero Aguilera, Nahuel R. Marziali, Lennart Moritz, Victoria Wingert, Katharina Klotz, Anke Schumann, Sarah C. Grünert, Ute Spiekerkoetter, Urs Berger, Ann-Kathrin Lederer, Roman Huber, Luciana Hannibal   +12 more
doaj   +1 more source

Insights into the regulation of DMSP synthesis in the diatom Thalassiosira pseudonana through APR activity, proteomics and gene expression analyses on cells acclimating to changes in salinity, light and nitrogen [PDF]

, 2014
Despite the importance of dimethylsulphoniopropionate (DMSP) in the global sulphur cycle and climate regulation, the biological pathways underpinning its synthesis in marine phytoplankton remain poorly understood.
A Koprivova, A Koprivova, A Nyyssölä, A Vairavamurthy, AJ Kettle, AMN Caruana, BL Nunn, BL Nunn, BR Lyon, DA Gage, DJ Franklin, DJC Pappin, DMJ Dickson, E Bucciarelli, E Harada, EV Armbrust, FH Haas, Gill Malin, GP Ayers, GV Wolfe, H Hesse, H Takahashi, Ive De Smet, J Blanco, J Stefels, J Vandesompele, JA Bick, JE Lovelock, JG McCoy, JR Gunson, K Harms, KG Porter, L Zolla, M Bochenek, M Steinke, MD Keller, MM Bradford, MS Khan, MW Pfaffl, N Ohkama, Nicola Louise Kettles, NL Hockin, P Vauclare, PS Summers, R Waditee, RC Greene, RJ Charlson, S Kopriva, S Kopriva, S Kopriva, S Rajagopal, S Ratti, Stanislav Kopriva, T Gröne, U Neuenschwander, V Doubnerová, W Loenen, W Sunda, Y Benjamini, Y Gao, Y Hui, Y Yamamoto   +61 more
core   +11 more sources

Proteogenomic characterization of cholangiocarcinoma

Hepatology, EarlyView., 2022
Proteogenomic characterization of cholangiocarcinoma with therapeutic strategies Abstract Background and Aims Cholangiocarcinoma (CCA) is a highly heterogeneous cancer with limited understanding and few effective therapeutic approaches. We aimed at providing a proteogenomic CCA characterization to inform biological processes and treatment ...
Mengjie Deng, Peng Ran, Lingli Chen, Yunzhi Wang, Zixiang Yu, Ke Cai, Jinwen Feng, Zhaoyu Qin, Yanan Yin, Subei Tan, Yang Liu, Chen Xu, Guoming Shi, Yuan Ji, Jian‐Yuan Zhao, Jian Zhou, Jia Fan, Yingyong Hou, Chen Ding   +18 more
wiley   +1 more source