Crystal structure and functional analysis of the SARS-coronavirus RNA cap 2'-O-methyltransferase nsp10/nsp16 complex. [PDF]
PLoS Pathogens, 2011 Cellular and viral S-adenosylmethionine-dependent methyltransferases are involved in many regulated processes such as metabolism, detoxification, signal transduction, chromatin remodeling, nucleic acid processing, and mRNA capping.
Etienne Decroly +12 more
doaj +4 more sources
Protective role of S-Adenosylmethionine against fructose-induced oxidative damage in obesity [PDF]
Journal of Mind and Medical Sciences, 2017 Introduction. It has been shown that S-adenosylmethionine (S-AMe) stimulates glutathione synthesis and increases cell resistance to the cytotoxic action of free radicals and pro-inflammatory cytokines. The aim of this study was to determine the effect of
Kameliya Zh Bratoeva +3 more
doaj +5 more sources
Site of Prenylation Reaction in Synthesis of Phylloquinone (Vitamin K1) by Spinach Chloroplasts [PDF]
, 1981 In spinach chloroplasts, 1,4-dihydroxy-2-naphthoate is prenylated by phytyldiphosphate and subsequently methylated by S-adenosylmethionine to form phylloquinol.
Baldwin +22 more
core +1 more source
Proteogenomic characterization of cholangiocarcinoma
Hepatology, EarlyView., 2022 Proteogenomic characterization of cholangiocarcinoma with therapeutic strategies Abstract Background and Aims Cholangiocarcinoma (CCA) is a highly heterogeneous cancer with limited understanding and few effective therapeutic approaches. We aimed at providing a proteogenomic CCA characterization to inform biological processes and treatment ...
Mengjie Deng +18 more
wiley +1 more source
NO sensitizes rat hepatocytes to proliferation by modifying S-adenosylmethionine levels [PDF]
, 2002 BACKGROUND & AIMS: Liver regeneration is a fundamental response of this organ to injury. Hepatocyte proliferation is triggered by growth factors, such as hepatocyte growth factor. However, hepatocytes need to be primed to react to mitogenic signals.
Avila, M.A. (Matías Antonio) +4 more
core +1 more source
Columbamine, the central intermediate in the late stages of protoberberine biosynthesis [PDF]
, 1986 A specific methyltransferase which in the presence of S-adenosylmethionine [SAM] converts columbamine to palmatine has been demonstrated to occur in cell cultures.
Rüffer, Martina, Zenk, Meinhart H.
core +1 more source
MTHFD1 controls DNA methylation in Arabidopsis. [PDF]
, 2016 DNA methylation is an epigenetic mechanism that has important functions in transcriptional silencing and is associated with repressive histone methylation (H3K9me).
Bischof, Sylvain +16 more
core +2 more sources
S-adenosyl-l-methionine: (S) -7,8,13, 14-tetrahydroberberine--n-methyltransferase, a branch point enzyme in the biosynthesis of benzophenanthridine and protopine alkaloids. [PDF]
, 1986 The enzyme which transfers the CH3-group of S-adenosylmethionine to the nitrogen atom of (S)-tetrahydroberberine and (S)-stylopine is found to occur in a number of plant cell cultures originating from species containing alkaloids; it is located at an ...
Amann +8 more
core +1 more source
Excess S-adenosylmethionine inhibits methylation via catabolism to adenine
Communications Biology, 2022 S-adenosylmethionine (SAM) is a widely available dietary supplement. Exogenous SAM is catabolized to adenine, an inhibitor of adenosylhomocysteinase, leading to widespread methylation inhibition and disruption of circadian rhythms in vitro and in mice.
Kazuki Fukumoto +9 more
doaj +1 more source
High folic acid consumption leads to pseudo-MTHFR deficiency, altered lipid metabolism, and liver injury in mice. [PDF]
, 2015 Increased consumption of folic acid is prevalent, leading to concerns about negative consequences. The effects of folic acid on the liver, the primary organ for folate metabolism, are largely unknown.
Best, A +10 more
core +1 more source