Results 21 to 30 of about 25,478 (242)
Metabolite-dependent regulation of gene expression in trypanosoma brucei [PDF]
, 2013 Mechanisms regulating gene expression in trypanosomatid protozoa differ significantly from those in other eukaryotes. Transcription of the genome appears to be more or less constitutive with the polyadenylation and trans-splicing of large polycistronic ...
Archer +34 more
core +1 more source
ACCUMULATION OF S-ADENOSYLMETHIONINE BY MICROORGANISMS [PDF]
Journal of Bacteriology, 1962 Gawel , L. J. (Oregon State University, Corvallis), J. R. Turner, and L. W. Parks . Accumulation of S-adenosylmethionine by microorganisms. J. Bacteriol. 83: 497–499. 1962.—A series of microorganisms selected to represent a variety of microbial types was cultured under conditions ...
L. W. Parks, J. R. Turner, L. J. Gawel
openaire +3 more sources
A natural riboswitch scaffold with self-methylation activity
Nature Communications, 2021 In humans, protein methyltransferase is responsible for RNA methylation using S-adenosylmethionine as a methyl group donor. Here the authors report a self-methylation activity of a bacterial riboswitch.
Laurin Flemmich +4 more
doaj +1 more source
S-adenosylhomocysteine as a methyl transfer catalyst in biocatalytic methylation reactions [PDF]
, 2019 S-adenosylmethionine-dependent methyltransferases form a large family of enzymes that can catalyse regio-, chemo- and stereospecific methylation of complex natural products.
Liao, Cangsong, Seebeck, Florian P.
core +1 more source
mSystems, 2019 To further our understanding of one-carbon metabolism in the protozoan parasite Leishmania, we conducted genomic screens to study how the parasite responded to sinefungin (SNF) selection.
Arijit Bhattacharya +5 more
doaj +1 more source
Vitamin B12-impaired metabolism produces apoptosis and Parkinson phenotype in rats expressing the transcobalamin-oleosin chimera in substantia nigra. [PDF]
PLoS ONE, 2009 BACKGROUND:Vitamin B12 is indispensable for proper brain functioning and cytosolic synthesis of S-adenosylmethionine. Whether its deficiency produces effects on viability and apoptosis of neurons remains unknown.
Carlos Enrique Orozco-Barrios +9 more
doaj +1 more source
环境与职业医学, 2023 BackgroundArsenic exposure can lead to liver dysfunction, liver steatosis, hepatitis, liver fibrosis, and other liver injuries, but its mechanism is still unclear and effective treatment methods are lacking.ObjectiveTo investigate the potential ...
Lu MA +5 more
doaj +1 more source
The Impact of One Carbon Metabolism on Histone Methylation
Frontiers in Genetics, 2019 The effect of one carbon metabolism on DNA methylation has been well described, bridging nutrition, metabolism, and epigenetics. This modification is mediated by the metabolite S-adenosyl methionine (SAM), which is also the methyl-donating substrate of ...
Magdalini Serefidou +2 more
doaj +1 more source
S-Adenosylmethionine for osteoarthritis of the knee or hip [PDF]
Cochrane Database of Systematic Reviews, 2008 Osteoarthritis is the most common form of joint disease and the leading cause of pain and disability in the elderly. S-Adenosylmethionine may be a viable treatment option but the evidence about its effectiveness and safety is equivocal.We set out to compare S-Adenosylmethionine (SAMe) with placebo or no specific intervention in terms of effects on pain
Rutjes A +3 more
openaire +5 more sources
S-adenosylmethionine and superoxide dismutase 1 synergistically counteract Alzheimer's disease features progression in tgCRND8 mice [PDF]
, 2017 Recent evidence emphasizes the role of dysregulated one-carbon metabolism in Alzheimer's Disease (AD). Exploiting a nutritional B-vitamin deficiency paradigm, we have previously shown that PSEN1 and BACE1 activity is modulated by one-carbon metabolism ...
Cavallaro, Rosaria A +4 more
core +2 more sources