Results 21 to 30 of about 60,031 (297)

NO sensitizes rat hepatocytes to proliferation by modifying S-adenosylmethionine levels [PDF]

, 2002
BACKGROUND & AIMS: Liver regeneration is a fundamental response of this organ to injury. Hepatocyte proliferation is triggered by growth factors, such as hepatocyte growth factor. However, hepatocytes need to be primed to react to mitogenic signals.
Avila, M.A. (Matías Antonio), Latasa, M.U. (María Ujué), Martinez-Chantar, M.L. (María Luz), Mato, J.M. (José María), Ruiz Garcia-Trevijano, E. (Elena)   +4 more
core   +1 more source

S-Adenosylmethionine Synthetase Is Required for Cell Growth, Maintenance of G0 Phase, and Termination of Quiescence in Fission Yeast

iScience, 2018
Summary: S-adenosylmethionine is an important compound, because it serves as the methyl donor in most methyl transfer reactions, including methylation of proteins, nucleic acids, and lipids.
Takeshi Hayashi, Takayuki Teruya, Romanas Chaleckis, Susumu Morigasaki, Mitsuhiro Yanagida   +4 more
doaj   +1 more source

S-adenosyl-l-methionine: (S) -7,8,13, 14-tetrahydroberberine--n-methyltransferase, a branch point enzyme in the biosynthesis of benzophenanthridine and protopine alkaloids. [PDF]

, 1986
The enzyme which transfers the CH3-group of S-adenosylmethionine to the nitrogen atom of (S)-tetrahydroberberine and (S)-stylopine is found to occur in a number of plant cell cultures originating from species containing alkaloids; it is located at an ...
Amann, Battersby, M Rueffer, M.H Zenk, Rueffer, Rueffer, Slavik, Takao, Takao   +8 more
core   +1 more source

MTHFD1 controls DNA methylation in Arabidopsis. [PDF]

, 2016
DNA methylation is an epigenetic mechanism that has important functions in transcriptional silencing and is associated with repressive histone methylation (H3K9me).
Bischof, Sylvain, Cokus, Shawn J, Díaz de la Garza, Rocío I, Feng, Suhua, Garcia-Salinas, Carolina, Groth, Martin, Hale, Christopher J, Hell, Ruediger, Jacobsen, Steven E, John, Amala, Long, Jeff A, Moissiard, Guillaume, Ramos-Parra, Perla A, Smith, Danielle C, Wang, Haifeng, Wirtz, Markus, Zhai, Jixian   +16 more
core   +2 more sources

S-adenosylmethionine metabolism and liver disease

Annals of Hepatology, 2013
Methionine is an essential amino acid that is metabolized mainly by the liver where it is converted to S-adenosylmethionine (SAMe) by the enzyme methionine adenosyltransferase.
José M. Mato, M. Luz Martínez-Chantar, Shelly C. Lu   +2 more
doaj   +1 more source

Metabolite-dependent regulation of gene expression in trypanosoma brucei [PDF]

, 2013
Mechanisms regulating gene expression in trypanosomatid protozoa differ significantly from those in other eukaryotes. Transcription of the genome appears to be more or less constitutive with the polyadenylation and trans-splicing of large polycistronic ...
Archer, Batey, Besteiro, Birkholtz, Breaker, Carter, Clayton, Coustou, De Gaudenzi, Ebikeme, Fairlamb, Hendriks, Jacob, Jensen, Kabani, Lamour, Mangold, Martinez-Calvillo, Nguyen, Perez-Leal, Persson, Phillips, Stuart, Veitch, Vincent, Ward, Willert, Willert, Willert, Wirtz, Wurst, Wurst, Xiao, Xiao, Zhang   +34 more
core   +1 more source

Site of Prenylation Reaction in Synthesis of Phylloquinone (Vitamin K1) by Spinach Chloroplasts [PDF]

, 1981
In spinach chloroplasts, 1,4-dihydroxy-2-naphthoate is prenylated by phytyldiphosphate and subsequently methylated by S-adenosylmethionine to form phylloquinol.
Baldwin, Block, Bryant, Dialameh, Douce, Haas, Hutson, Jensen, Joo, Lee, Lichtenthaler, Lichtenthaler, Martius, Mayer, Rüdiger, Shineberg, Soil, Soll, Soll, Suttie, Thomas, Young, Zenk   +22 more
core   +1 more source

Crystal structure and functional analysis of the SARS-coronavirus RNA cap 2'-O-methyltransferase nsp10/nsp16 complex.

PLoS Pathogens, 2011
Cellular and viral S-adenosylmethionine-dependent methyltransferases are involved in many regulated processes such as metabolism, detoxification, signal transduction, chromatin remodeling, nucleic acid processing, and mRNA capping.
Etienne Decroly, Claire Debarnot, François Ferron, Mickael Bouvet, Bruno Coutard, Isabelle Imbert, Laure Gluais, Nicolas Papageorgiou, Andrew Sharff, Gérard Bricogne, Miguel Ortiz-Lombardia, Julien Lescar, Bruno Canard   +12 more
doaj   +1 more source

High folic acid consumption leads to pseudo-MTHFR deficiency, altered lipid metabolism, and liver injury in mice. [PDF]

, 2015
Increased consumption of folic acid is prevalent, leading to concerns about negative consequences. The effects of folic acid on the liver, the primary organ for folate metabolism, are largely unknown.
Best, A, Caudill, MA, Christensen, KE, Deng, L, Greene, ND, Leung, KY, Lévesque, N, Malysheva, OV, Mikael, LG, Rozen, R, Wu, Q   +10 more
core   +1 more source

S-Adenosylmethionine and Pneumocystis carinii [PDF]

Journal of Biological Chemistry, 2000
We previously reported that S-adenosylmethionine (AdoMet), a key molecule in methylation reactions and polyamine biosynthesis, enhances axenic culture of the AIDS-associated opportunistic fungal pathogen Pneumocystis carinii. Here we report that AdoMet is absolutely required for continuous growth. Two transporters are present, one high affinity, K(m) =
S, Merali, D, Vargas, M, Franklin, A B, Clarkson   +3 more
openaire   +2 more sources