Results 51 to 60 of about 25,478 (242)

Impairment of methyl cycle affects mitochondrial methyl availability and glutathione level in Down's Sindrome [PDF]

, 2011
In Down's syndrome there is evidence that increased gene expression coding for specific cystathionine beta-synthase translates directly into biochemical aberrations, which result in a biochemical and metabolic imbalance of the methyl status.
ANDRIA G, CASTEGNA A, IACOBAZZI F, IACOBAZZI V., INFANTINO, VITTORIA, SCALA I, SPERA I   +6 more
core   +2 more sources

Loss of STARD7 Triggers Metabolic Reprogramming and Cell Cycle Arrest in Breast Cancer

Advanced Science, EarlyView.
Breast cancer cells undergo metabolic and transcriptomic reprogramming to support aberrant cell proliferation. Their mitochondria rely on the transfer of phosphatidylcholine from the endoplasmic reticulum to their membranes by STARD7, a candidate upregulated in breast cancer, to be functional.
Ewelina Dondajewska, Paula Allepuz‐Fuster, Chloé Maurizy, Alexandre Hego, Sandra Ormenese, Quentin Lion, Arnaud Blomme, Pierre Close, Arnaud Lavergne, Latifa Karim, Marc Thiry, Ivan Nemazanyy, Roopesh Krishnankutty, Jair Marques Jr, Alex von Kriegsheim, Nathaniel F. Henneman, Ganna Panasyuk, Kateryna Shostak, Alain Chariot   +18 more
wiley   +1 more source

A [4Fe-4S]-Fe(CO)(CN)-L-cysteine intermediate is the first organometallic precursor in [FeFe] hydrogenase H-cluster bioassembly. [PDF]

, 2018
Biosynthesis of the [FeFe] hydrogenase active site (the 'H-cluster') requires the interplay of multiple proteins and small molecules. Among them, the radical S-adenosylmethionine enzyme HydG, a tyrosine lyase, has been proposed to generate a complex that
A Pagnier, A Silakov, Daniel L. M. Suess, DL Suess, DL Suess, DL Suess, DW Mulder, DW Mulder, DW Mulder, DW Mulder, E Pilet, EJ Reijerse, EM Shepard, EM Shepard, EM Shepard, Guodong Rao, J Barber, JA Birrell, JA Christner, JB Broderick, JK Rubach, JM Kuchenreuther, JM Kuchenreuther, JM Kuchenreuther, JM Kuchenreuther, JR Morton, JW Peters, JW Peters, KA Vincent, Lizhi Tao, M Carepo, M Winkler, MC Posewitz, ME Boyer, ME Pandelia, ND Lanz, P Berto, P Dinis, PM Vignais, R Gilbert-Wilson, R. David Britt, RC Driesener, RC Driesener, RJ Krueger, RJ Krueger, SE McGlynn, W Lubitz, Y Nicolet, Y Nicolet, Y Nicolet   +49 more
core   +1 more source

Rethinking the bioavailability and cellular transport properties of S-adenosylmethionine

Cell Stress, 2021
S-adenosylmethionine (SAM) is a versatile metabolite that participates in a wide range of reactions such as methylation and transsulfuration. These capabilities allow SAM to influence cellular processes such as gene expression and redox balancing.
Yudong Sun, Jason W. Locasale
doaj   +1 more source

PRMT3‐Mediated H4R3me2a Promotes Primary Age‐Related Tauopathy by Driving Tau Hyperphosphorylation in Neuron

Advanced Science, EarlyView.
This study identifies PRMT3‐mediated H4R3me2a as a critical driver of tau hyperphosphorylation in primary age‐related tauopathy. Mechanistic insights reveal that the PRMT3/H4R3me2a/miR‐448 axis suppresses IGF1R expression via epigenetic regulation, further dysregulating the PI3K/AKT/GSK3β pathway.
Haotian Liu, Xinnan Liu, Fengyuan Tian, Yashuang Chen, Jingying Li, Xue Wang, Wenying Qiu, Xia Wang, Chao Ma, Wei Ge   +9 more
wiley   +1 more source

S-Adenosylmethionine: a control switch that regulates liver function [PDF]

, 2002
Genome sequence analysis reveals that all organisms synthesize S-adenosylmethionine (AdoMet) and that a large fraction of all genes is AdoMet-dependent methyltransferases.
Avila, M.A. (Matías Antonio), Corrales, F.J. (Fernando José), Lu, S.C. (Shelly C.), Mato, J.M. (José María)   +3 more
core   +2 more sources

S-Adenosylmethionine Synthetase Is Required for Cell Growth, Maintenance of G0 Phase, and Termination of Quiescence in Fission Yeast

iScience, 2018
Summary: S-adenosylmethionine is an important compound, because it serves as the methyl donor in most methyl transfer reactions, including methylation of proteins, nucleic acids, and lipids.
Takeshi Hayashi, Takayuki Teruya, Romanas Chaleckis, Susumu Morigasaki, Mitsuhiro Yanagida   +4 more
doaj  

Dithiothreitol causes toxicity in C. elegans by modulating the methionine–homocysteine cycle

eLife, 2022
The redox reagent dithiothreitol (DTT) causes stress in the endoplasmic reticulum (ER) by disrupting its oxidative protein folding environment, which results in the accumulation and misfolding of the newly synthesized proteins. DTT may potentially impact
Gokul G, Jogender Singh
doaj   +1 more source

Longitudinal Metabolomics in Amyotrophic Lateral Sclerosis Implicates Impaired Lipid Metabolism

Annals of Neurology, EarlyView.
Objective Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by altered metabolome and energy homeostasis, manifesting with body mass index changes and hypermetabolism—both prognostic of disease progression and survival.
Kai Guo, Masha G. Savelieff, Dae‐Gyu Jang, Samuel J. Teener, Lili Zhao, Junguk Hur, Stephen A. Goutman, Eva L. Feldman   +7 more
wiley   +1 more source

Effect of piroxicam, metamizol, and S-adenosylmethionine in a murine model of experimental trichomoniasis

Parasite, 2005
Biological effects of piroxicam, metamizol, and S-adenosylmethionine (S-AMET) have been tested in NMRI mice infected intraperitoneally with Trichomonas vaginalis. An intraperitoneal treatment during ten preinfection days with piroxicam (10 mg/Kg/day), or
Nogal-Ruiz J.J., Gómez-Barrio A., Escario J.A., Montero-Pereira D., Martínez-Fernández A.R.   +4 more
doaj   +1 more source