Results 61 to 70 of about 60,031 (297)

S-Adenosylmethionine in a Neuroblastoma [PDF]

Pediatric Research, 1971
Soluble extracts of a neuroblastoma did not require additional methyl donor, S-adenosyl-L-methionine (SAM), for maximal catechol O-methltransferase activity. Prior dialysis of the extract resulted in complete loss of enzymatic activity which could be partially recovered by addition of SAM to the reaction mixture.
openaire   +2 more sources

Acute ethanol-induced liver injury is prevented by betaine administration

Frontiers in Physiology, 2022
Binge drinking is the most common form of excessive alcohol use. Repeated episodes of binge drinking cause multiple organ injuries, including liver damage.
Madan Kumar Arumugam, Madan Kumar Arumugam, Srinivas Chava, Srinivas Chava, Sathish Kumar Perumal, Sathish Kumar Perumal, Matthew C. Paal, Matthew C. Paal, Karuna Rasineni, Karuna Rasineni, Karuna Rasineni, Murali Ganesan, Murali Ganesan, Terrence M. Donohue, Terrence M. Donohue, Natalia A. Osna, Natalia A. Osna, Kusum K. Kharbanda, Kusum K. Kharbanda, Kusum K. Kharbanda   +19 more
doaj   +1 more source

Balanced Expression of the Diiron Oxygenase BioE Is Essential for Biotin Homeostasis in Elizabethkingia meningoseptica

Advanced Science, EarlyView.
BioE is a new diiron oxygenase that catalyzes the conversion of long‐chain acyl groups into pimeloyl thioester, initiating biotin synthesis. The overexpression of EmBioE disrupts lipid metabolic homeostasis, requiring repressor BioL to maintain a balance between long‐chain fatty acids and biotin synthesis.
Meng Zhang, Ying‐ying Fu, Xiaoqiang Yang, Qiuying Qin, Xinyu Su, Jiaming Fang, Yanhua Kang, Qingwen He, Zhi Ruan, Yongchang Xu   +9 more
wiley   +1 more source

Functional and Pathological Roles of AHCY

Frontiers in Cell and Developmental Biology, 2021
Adenosylhomocysteinase (AHCY) is a unique enzyme and one of the most conserved proteins in living organisms. AHCY catalyzes the reversible break of S-adenosylhomocysteine (SAH), the by-product and a potent inhibitor of methyltransferases activity.
Pedro Vizán, Luciano Di Croce, Luciano Di Croce, Luciano Di Croce, Sergi Aranda   +4 more
doaj   +1 more source

Alternative Pathway for Methyl Supply through the Coupling of SHMT1 and PEMT to Maintain Astrocytic Homeostasis in Parkinson's Disease

Advanced Science, EarlyView.
In Parkinson's disease, SHMT1 downregulation disrupts its interaction with PEMT in astrocytes, reducing SAM levels. This leads to H3K4me1 hypomethylation and decreased Slc1a2/Glul expression, ultimately exacerbating neuroexcitotoxicity and dopaminergic neuron loss.
Yue‐Han Chen, Rong‐Xin Zhu, Nuo‐Xi Zhang, Ting‐Ting Sun, Xi‐Wei Zhang, Yu‐Jie Zhao, Ben‐Yu He, Hang Yao, Ren‐Hong Du, Lei Cao, Wen‐Bin Zhang, Wei‐Guo Liu, Yun Cai, Cong Wang, Gang Hu, Yao Wei, Yang Liu, Ming Lu   +17 more
wiley   +1 more source

EFFECT OF S-ADENOSYLMETHIONINE ON HEPATIC AND METABOLIC DISORDERS IN GUINEA PIGS WITH NONALCOHOLIC STEATOHEPATITIS

İstanbul Tıp Fakültesi Dergisi
Objective: S-adenosylmethionine (SAM) has antioxidant and anti-inflammatory actions and hepatoprotective potential. In this study, the therapeutic effectiveness of SAM was investigated in high-fat/cholesterol diet (HFCD)-induced non-alcoholic ...
İlknur Bingül, Canan Küçükgergin, Abdurrahman Fatih Aydın, Aydın Çevik, Merva Soluk Tekkeşin, Necat Vakur Olgaç, Semra Doğru Abbasoğlu, Mehmet Müjdat Uysal   +7 more
doaj   +1 more source

S-Adenosylmethionine (SAMe) in major depressive disorder (MDD): a clinician-oriented systematic review

Annals of General Psychiatry, 2020
Background Major depressive disorder (MDD) is a recurrent illness with high rates of chronicity, treatment-resistance, and significant economic impact.
Alessandro Cuomo, Bruno Beccarini Crescenzi, Simone Bolognesi, Arianna Goracci, Despoina Koukouna, Rodolfo Rossi, Andrea Fagiolini   +6 more
doaj   +1 more source

Higher S-adenosylhomocysteine and lower ratio of S-adenosylmethionine to S-adenosylhomocysteine were more closely associated with increased risk of subclinical atherosclerosis than homocysteine

Frontiers in Nutrition, 2022
AimTo examine the relationship of C1 metabolites of the methionine cycle with the risk of subclinical atherosclerosis (SA) in the Chinese population.MethodsA total of 2,991 participants aged 45–75 years old were included for data analyses based on the ...
Jinghe Xiao, Yiran You, Xu Chen, Yi Tang, Yuming Chen, Yuming Chen, Qiannan Liu, Zhaomin Liu, Zhaomin Liu, Wenhua Ling, Wenhua Ling   +10 more
doaj   +1 more source

Islet Amyloid Polypeptide Modelled to Simulate Diabetes Co‐Oligomerized with β‐Amyloid 1‐42 Reproducing the Pathological Cascade of Alzheimer's Disease in Human Cerebral Organoids

Advanced Science, EarlyView.
Human islet amyloid polypeptide (hIAPP) was used to mimic T2DM, and Aβ42‐hIAPP co‐oligomers were delivered into the human mature cerebral organoids (COs), which reproduce typical AD pathology and significant neuronal death more closely resembling that of AD patients.
Jin Yan, Zhimeng Tang, Yanyu Luo, Bin Liu, Xinxin Huang, Jun Wei, Feng Yue   +6 more
wiley   +1 more source

T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities

Advanced Science, EarlyView.
T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu, Xiaoyu Yao, Qingyang Wang, Mengrui Yang, Runze Li, Jiangjiang Qin, Jing Zhuang, Changgang Sun   +7 more
wiley   +1 more source