Results 71 to 80 of about 25,478 (242)

S-adenosylmethionine Levels Regulate the Schwann Cell DNA Methylome [PDF]

, 2014
SummaryAxonal myelination is essential for rapid saltatory impulse conduction in the nervous system, and malformation or destruction of myelin sheaths leads to motor and sensory disabilities. DNA methylation is an essential epigenetic modification during
Aransay, Ana María, Berdasco, María, Esteller, Manel, Fernandez, Agustín F., Fraga, Mario F., Iruarrizaga-Lejarreta, Marta, Jessen, Kristján R., Lavin, José Luis, Lozano, Juan José, Lu, Shelly C., Luka, Zigmund, Martínez-Chantar, María L., Mato, José M., Mirsky, Rhona, Mósen-Ansorena, David, Turmaine, Marc, Varela-Rey, Marta, Wagner, Conrad, Woodhoo, Ashwin   +18 more
core   +1 more source

Interplay of serum taurine, S-adenosylmethionine, and cysteine levels in cancer risk: a prospective study

Frontiers in Pharmacology
BackgroundAmino acids are known to play critical roles in cancer metabolism and progression. Among them, taurine, S-adenosylmethionine (SAM), and cysteine have garnered particular attention due to their interconnected metabolic pathways.
Chenan Liu, Chenan Liu, Chenan Liu, Chenan Liu, Chenan Liu, Tong Liu, Tong Liu, Tong Liu, Tong Liu, Tong Liu, Yaping Wei, Jinyu Shi, Jinyu Shi, Jinyu Shi, Jinyu Shi, Jinyu Shi, Li Deng, Li Deng, Li Deng, Mengmeng Song, Hanping Shi, Hanping Shi, Hanping Shi, Hanping Shi, Hanping Shi   +24 more
doaj   +1 more source

S-Adenosylmethionine May Mitigate Obstructive Sleep Apnea in an Adult with Down Syndrome: A Case Report

Nature and Science of Sleep, 2022
Silvano Dragonieri,1 Giovanna Elisiana Carpagnano,1 Salvatore Caccamese2 1Department of Respiratory Diseases, University of Bari, Bari, Italy; 2Department of Chemical Sciences, University of Catania, Catania, ItalyCorrespondence: Silvano ...
Dragonieri S, Carpagnano GE, Caccamese S
doaj  

The Oncogene PDRG1 Is an Interaction Target of Methionine Adenosyltransferases. [PDF]

PLoS ONE, 2016
Methionine adenosyltransferases MAT I and MAT III (encoded by Mat1a) catalyze S-adenosylmethionine synthesis in normal liver. Major hepatic diseases concur with reduced levels of this essential methyl donor, which are primarily due to an expression ...
Claudia Pérez, Francisco J Pérez-Zúñiga, Francisco Garrido, Edel Reytor, Francisco Portillo, María A Pajares   +5 more
doaj   +1 more source

Noncoding RNAs in Host–Microbiota Interaction

Animal Research and One Health, EarlyView.
The intricate interplay between gut microbiota and the host exerts a profound impact on host biological processes and disease development. This review highlights the pivotal role of noncoding RNAs (ncRNAs) in this interaction. Host ncRNAs regulate gene expression and microbiota composition, whereas microbial small RNAs (sRNAs) modulate host gene ...
Ziyi Zhao, Ni Li, Jingyi Xu, Jianrong Ren, Xiaojun Yang, Xinyi Li, Junhu Yao, Shengru Wu   +7 more
wiley   +1 more source

Diversity of ThDP‐Dependent Enzymes Forming Chiral Tertiary Alcohols

ChemBioChem, EarlyView.
Chiral tertiary alcohols are widespread in nature and bioactive compounds; however, their asymmetric synthesis faces several challenges. This review outlines the toolbox of ThDP‐dependent enzymes able to produce tertiary alcohols through the formation of CC bond formation using ketones as acceptor substrates. Herein, the substrate scope, the diversity
Daniela Bjarnesen, Lucrezia Lanza, Francesco Presini, Pier Paolo Giovannini, Michael Müller   +4 more
wiley   +1 more source

Enzymatic Cleavage of S-Adenosylmethionine

Journal of Biological Chemistry, 1959
S-adenosylmethionine, known for some time to be the biological methyl donor in mammalian enzymatic transmethylation reactions (1,2), has more recently been implicated in other transalkylation reactions in bacteria and yeast (3-6). The enzyme system catalyzing the condensation of ATP and methionine to form AMe’ has been found in a variety of tissues and
openaire   +3 more sources

Hybrid Molecules as Efficient Drugs against Multidrug‐Resistant Malaria Parasites

ChemMedChem, EarlyView.
Among hybrid molecules currently developed as antimalarial drug candidates, emoquine‐1 exhibits high activity against all the multidrug‐resistant Plasmodium strains tested up to now, including artemisinin‐resistant quiescent parasites, critical parameters for promising antimalarial drugs. It is also curative in mouse malaria.
Anne Robert, Lucie Paloque, Jean‐Michel Augereau, Flore Nardella, Michel Nguyen, Bernard Meunier, Françoise Benoit‐Vical   +6 more
wiley   +1 more source

Biomarkers and subtypes of deranged lipid metabolism in non-alcoholic fatty liver disease. [PDF]

, 2019
Nonalcoholic fatty liver disease (NAFLD) is a heterogeneous and complex disease that is imprecisely diagnosed by liver biopsy. NAFLD covers a spectrum that ranges from simple steatosis, nonalcoholic steatohepatitis (NASH) with varying degrees of fibrosis,
Alonso, Cristina, Lu, Shelly C, Mato, José M, Noureddin, Mazen   +3 more
core  

Protective effect of betaine against galactosamine-induced acute liver injury in rats

Journal of Functional Foods, 2018
We investigated the protective effect of betaine against galactosamine (GalN)-induced acute hepatic injury. Male rats received betaine from 2 wk prior to GalN treatment.
Yeo Jin Choi, Jong Deok Na, Doo Sung Jun, Young Chul Kim   +3 more
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