Results 101 to 110 of about 15,826,951 (219)
Nutrient-dependent changes of protein palmitoylation: impact on nuclear enzymes and regulation of gene expression. [PDF]
, 2018 Diet is the main environmental stimulus chronically impinging on the organism throughout the entire life. Nutrients impact cells via a plethora of mechanisms including the regulation of both protein post-translational modifications and gene expression ...
Spinelli M +5 more
core +1 more source
Chemistry – A European Journal, EarlyView.This review highlights biocatalytic prenylation as a versatile strategy for tailoring the functional properties of peptides and proteins. By comparing branched isoprenoids with linear lipids, we illustrate how specific prenyl architectures modulate the behaviors of lipidated proteins within membrane environments.
Daisuke Fujinami +2 more
wiley +1 more source
Palmitoylation as a Functional Regulator of Neurotransmitter Receptors
, 2018 The majority of neuronal proteins involved in cellular signaling undergo different posttranslational modifications significantly affecting their functions.
Vladimir S. Naumenko, Evgeni Ponimaskin
core +2 more sources
ESC Heart Failure, Volume 12, Issue 2, Page 1386-1397, April 2025.Sequeira et al. reveal how the glucagon‐like peptide‐1 receptor agonist (GLP‐1‐RA) semaglutide restores cardiomyocyte function in rats subjected to a high‐fat/high‐fructose diet (HFD). Employing fluorescence‐ and patch‐clamp technology in isolated cardiac myocytes, they demonstrate that semaglutide reverses HFD‐induced activation of L‐type calcium ...
Vasco Sequeira +12 more
wiley +1 more source
S-palmitoylation of Rotavirus NSP4
, 2020 Rotavirus is the primary cause of gastroenteritis in children. The clinical symptoms of the disease include fever, vomiting and diarrhoea, which can be fatal due to excessive fluid loss.
Azad, Shahriar
core
International Journal of Cancer, EarlyView.MEF2B and BCL6 have established functions in germinal center B‐cell biology and lymphomagenesis. The mechanism of MEF2B deregulation and its significance for cell survival in Burkitt lymphoma however remain unclear. This study highlights MEF2B as a crucial transcription factor in Burkitt lymphoma and suggests ZDHHC11 as an upstream regulator of MEF2B ...
Lotteke J. Y. M. Ziel‐Swier +12 more
wiley +1 more source
iLABMED, EarlyView.This article reviews the pivotal role of post‐translational modifications of proteins in the development and progression of hematologic malignancies, and explores their clinical translation potential as novel biomarkers and therapeutic targets. ABSTRACT Post‐translational modifications (PTMs) of proteins have emerged as critical regulators in the ...
Yuxuan Han +6 more
wiley +1 more source
Global, site-specific analysis of neuronal protein S-acylation
Scientific Reports, 2017 Protein S-acylation (palmitoylation) is a reversible lipid modification that is an important regulator of dynamic membrane-protein interactions. Proteomic approaches have uncovered many putative palmitoylated proteins however, methods for comprehensive ...
Mark O. Collins +2 more
doaj +1 more source
A compendium of extracellular vesicle biogenesis inhibitors: From bench to bedside
Interdisciplinary Medicine, EarlyView.This review explores a decade of research on extracellular vesicles (EVs), detailing their biogenesis and roles in health and disease. It emphasizes EVs' relevance for potential medical applications covering various conditions such as cancer, neurodegeneration, inflammation, and infectious diseases, bridging experimental findings with clinical ...
Stefano Vecchione +2 more
wiley +1 more source
S-palmitoylation: A novel player in cancer and its emerging therapeutic implications
Cell InvestigationS-palmitoylation is a reversible post-translational lipid modification involving the covalent attachment of palmitic acid to cysteine residues, thereby regulating protein localization, stability, trafficking, and function.
Ruiheng Wang +11 more
doaj +1 more source