Results 121 to 130 of about 21,089,371 (171)
Biogenesis of TNF‐α‐insights into proteostasis and inflammation
The FEBS Journal, Volume 293, Issue 18, Page 5645-5663, September 2026.TNF‐α biogenesis, trafficking, and signalling are tightly and reciprocally coupled to cellular proteostasis systems, including ER chaperones and endoplasmic reticulum‐associated degradation. This bidirectional crosstalk determines whether TNF‐α responses are adaptive or proteotoxic.
Bailasan Haidar +3 more
wiley +1 more source
Reviews in Aquaculture, Volume 18, Issue 4, September 2026.This manuscript systematically elucidates the molecular mechanisms underlying absorption, transport, and metabolism of Astaxanthin in aquatic animals, through the analysis of biological functions, transport proteins, and enzyme metabolism system. Furthermore, it outlines future molecular research strategies for Astaxanthin, providing a theoretical ...
Huakang Peng +12 more
wiley +1 more source
Cell Death and DiseaseRap2b, a proto-oncogene upregulated in colorectal cancer (CRC), undergoes protein S-palmitoylation at specific C-terminus sites (C176/C177). These palmitoylation sites are crucial for Rap2b localization on the plasma membrane (PM), as mutation of C176 or
Jiangli Zhu +15 more
doaj +1 more source
Functional Specialization of Clathrin‐Independent Endocytic Routes: Mechanisms and Cellular Roles
Traffic, Volume 27, Issue 3, September 2026.Distinct clathrin‐independent endocytic (CIE) routes support specialized cellular functions across different contexts. Created with Biorender.com. ABSTRACT Clathrin‐independent endocytosis (CIE) comprises a diverse repertoire of internalization mechanisms that operate in parallel with clathrin‐mediated endocytosis.
Andrea Francesco Benvenuto +5 more
wiley +1 more source
Palmitoylation as a Functional Regulator of Neurotransmitter Receptors
, 2018 The majority of neuronal proteins involved in cellular signaling undergo different posttranslational modifications significantly affecting their functions.
Vladimir S. Naumenko, Evgeni Ponimaskin
core +1 more source
ChemMedChem, Volume 21, Issue 16, 27 August 2026.Ligand‐based virtual screening of over five million compounds identifies a thienopyrimidinone hit as a novel allosteric nSMase2 modulator. Structure‐guided optimisation improves inhibitory potency and delivers derivatives with antiviral activity against West Nile virus, expanding the chemical space of nSMase2 inhibitors and supporting host‐directed ...
Hadrián Álvarez‐Fernández +6 more
wiley +1 more source
THE ROLE OF ZDHHC7 AND S-PALMITOYLATION IN ANTIVIRAL INNATE IMMUNITY
135 pagesProtein lipidation including cysteine palmitoylation (S-palmitoylation) significantly enhances protein hydrophobicity and membrane association. S-palmitoylation, catalyzed by the ZDHHC (zinc finger Asp-His-His-Cys) family of enzymes, occurs on a
Liu, Yinong
core +1 more source
Journal of Lipid ResearchAt least 10% of proteins constituting the human proteome are subject to S-acylation by a long-chain fatty acid, thioesterified to a Cys thiol side chain.
Naoko Adachi +2 more
doaj +1 more source
The EMBO JournalLipid transfer proteins mediate the non-vesicular transport of lipids at membrane contact sites to regulate the lipid composition of organelle membranes. Despite significant recent advances in our understanding of the structural basis for lipid transfer,
Wenhui Zheng +9 more
doaj +1 more source
Frontiers in Cell and Developmental BiologyRenal tubular injury contributes substantially to the progression of acute kidney injury (AKI) and chronic kidney disease (CKD). S-palmitoylation is a reversible lipid modification that regulates protein localization, stability, trafficking, and ...
Miao Li +5 more
doaj +1 more source