Results 121 to 130 of about 15,826,951 (219)
Membrane‐type I metalloproteinase (MT1‐MMP): A key modifier of extracellular matrix microenvironment
The FEBS Journal, EarlyView.MT1‐MMP: A cellular microenvironment modifier. MT1‐MMP is a major cellular microenvironment modifier, maintaining collagen homeostasis by degrading excess collagen (A), creating a migration path in motile cells such as cancer cells (B), modulating local microenvironmental signaling by cleaving transmembrane receptors (C), and destroying tissue ...
Yoshifumi Itoh, Masaki Inada
wiley +1 more source
Biogenesis of TNF‐α‐insights into proteostasis and inflammation
The FEBS Journal, EarlyView.TNF‐α biogenesis, trafficking, and signalling are tightly and reciprocally coupled to cellular proteostasis systems, including ER chaperones and endoplasmic reticulum‐associated degradation. This bidirectional crosstalk determines whether TNF‐α responses are adaptive or proteotoxic.
Bailasan Haidar +3 more
wiley +1 more source
Cell Communication and SignalingBackground Abnormal activation of FAK is associated with tumor development and metastasis. Through interactions with other intracellular signalling molecules, FAK influences cytoskeletal remodelling, modulation of adhesion signalling, and activation of ...
Yang Wang +8 more
doaj +1 more source
The emerging role of the Hippo signaling pathway in interorgan crosstalk
The FEBS Journal, EarlyView.Hippo signaling functions as a central hub of interorgan communication. Systemic cues from the gut, adipose tissue, and skeletal muscle—including hormones, metabolites, and microbial signals—regulate YAP/TAZ activity in a tissue‐ and context‐dependent manner.
Gahyeon Song +2 more
wiley +1 more source
Bio‐active designed peptide for hair keratin strengthening
International Journal of Cosmetic Science, EarlyView.Bioactive tripeptides through in silico screening revealed KCV (Tripeptide‐132) as the most promising keratin‐targeting candidate. Experimental studies confirmed its superior hair‐strengthening performance with 44% tensile strength enhancement, 50% breakage reduction, improved surface integrity and fibre penetration.
Chan‐Su Rha +6 more
wiley +1 more source
Biological Research, 2002 Protein domains play a fundamental role in the spatial and temporal organization of intracellular signaling systems. While protein phosphorylation has long been known to modify the interactions that underlie this organization, the dynamic cycling of lipids should now be included amongst the posttranslational processes determining specificity in signal ...
openaire +4 more sources
THE ROLE OF ZDHHC7 AND S-PALMITOYLATION IN ANTIVIRAL INNATE IMMUNITY
135 pagesProtein lipidation including cysteine palmitoylation (S-palmitoylation) significantly enhances protein hydrophobicity and membrane association. S-palmitoylation, catalyzed by the ZDHHC (zinc finger Asp-His-His-Cys) family of enzymes, occurs on a
Liu, Yinong
core +1 more source
Journal of Integrative Plant Biology, EarlyView.This review focuses on mitogen‐activated protein kinase (MAPK) activation and summarizes how plants regulate and integrate MAPK signaling in modulating plant immune responses. It also examines the effectors pathogens have evolved to manipulate MAPK activation and thereby inhibit plant immunity.
Guitao Zhong +3 more
wiley +1 more source
S-palmitoylation of NOD2 controls its localization to the plasma membrane [PDF]
Journal of Lipid Research, 2021 Charneal L. Dixon, Gregory D. Fairn
openaire +3 more sources
Structural and functional investigation of the cytoplasmic domain of the Fas death receptor
, 2015 Activation of the transmembrane death receptor Fas (CD95/APO-1) by a membrane bound ligand (FasL/CD95L) activates the extrinsic pathway of apoptosis. Intracellular Fas death domains (DDs) are induced to oligomerise enabling binding to the adaptor protein
Wildsmith, GC
core