Results 161 to 170 of about 22,830,963 (211)

Palmitoylation in cardiometabolic diseases: From molecular mechanisms to clinical implications

Pharmacological Research
Cardiometabolic diseases (CMDs), encompassing both cardiovascular diseases and metabolic syndromes, are among the leading causes of global morbidity and mortality.
Shenghui Feng, Yue Zhou, Linjuan Guo, Yan Liang, Wengen Zhu   +4 more
doaj   +1 more source

ZDHHC2‐Dependent Palmitoylation Dictates Ferroptosis and Castration Sensitivity in Prostate Cancer via Controlling ACSL4 Degradation and Lipid Peroxidation

Advanced Science
Ferroptosis represents a promising vulnerability to overcome therapeutic resistance in castration‐resistant prostate cancer (CRPC). While S‐palmitoylation of lipid peroxide‐scavenging proteins such as GPX4 and SLC7A11 has been shown to suppress ...
Shuai Shao, Wei Li, Yulong Hong, Ruijiang Zeng, Liang Zhu, Lu Yi, Yuan Li, Yinhuai Wang, Haojie Huang, Xuewen Jiang, Xin Jin   +10 more
doaj   +1 more source

S-palmitoylation of NOD2 controls its localization to the plasma membrane [PDF]

Journal of Lipid Research, 2021
Charneal L. Dixon, Gregory D. Fairn
openaire   +3 more sources

Palmitoylation: an emerging therapeutic target bridging physiology and disease

Cellular & Molecular Biology Letters
Palmitoylation is a reversible post-translational lipid modification of proteins, catalyzed by the Zinc finger DHHC domain-containing (ZDHHC) family of palmitoyltransferases.
Weini Li, Jie Shen, Aojia Zhuang, Ruiheng Wang, Quanqi Li, Anas Rabata, Yanan Zhang, DuoYao Cao   +7 more
doaj   +1 more source

ZDHHC4-mediated ZEB-2 S-palmitoylation promotes melanoma epithelial-mesenchymal transition via deubiquitinating and stabilizing ZEB-2. [PDF]

Cell Mol Life Sci
Chen S, Shen H, Zhang H, Wang Q, Ding Y, Pu X, Yang C, Pang R, Yang Z.   +8 more
europepmc   +1 more source

Discovery and Characterization of IFITM S-Palmitoylation. [PDF]

Viruses, 2023
Das T, Hang HC.
europepmc   +1 more source

Protein S-palmitoylation regulates different stages of meiosis in Schizosaccharomyces pombe. [PDF]

Life Sci Alliance, 2023
Pham TV, Hsiao WY, Wang YT, Yeh SD, Wang SW.   +4 more
europepmc   +1 more source

TLR9-Driven S-Palmitoylation in Dendritic Cells Reveals Immune and Metabolic Protein Targets. [PDF]

Eur J Immunol
Quiroz JN, Sielaff M, Kondrateva D, Boukhallouk F, Godoy GJ, Molina CR, Moonen B, Motran CC, Bogie J, Luján HD, Tenzer S, Sparwasser T, Berod L.   +12 more
europepmc   +1 more source

Pharmacological inhibition of protein S-palmitoylation suppresses osteoclastogenesis and ameliorates ovariectomy-induced bone loss. [PDF]

J Orthop Translat, 2023
Ma L, Zhang L, Liao Z, Xiu C, Luo X, Luo N, Zhang L, He G, Chen J.   +8 more
europepmc   +1 more source

Palmitic acid aggravates atopic dermatitis by regulating SGK1/NEDD4L-involved cutaneous neuroimmune inflammation through driving TRPV1 and MRGPRB2 S-palmitoylation. [PDF]

Inflamm Res
Chen B, Yang J, Song T, Wu W, Hao F, Yang Z.   +5 more
europepmc   +1 more source