Results 71 to 80 of about 21,088,255 (155)

Piceatannol SNEDDS Attenuates Estradiol-Induced Endometrial Hyperplasia in Rats by Modulation of NF-κB and Nrf2/HO-1 Axes

, 2022
Endometrial hyperplasia (EH) is the most common risk factor for endometrial malignancy in females. The pathogenesis of EH has been directly linked to uterine inflammation, which can result in abnormal cell division and decreased apoptosis.
Basma G. Eid, Najlaa S. Binmahfouz, Shaik, Rasheed A., Lenah S. Binmahfouz, Rasheed A. Shaik, Ashraf B. Abdel-Naim, Binmahfouz, Lenah S., Eid, Basma G., Binmahfouz, Najlaa S., Bagher, Amina M., Amina M. Bagher, Abdel-Naim, Ashraf B.   +11 more
core   +1 more source

Supersaturated self-nanoemulsifying drug delivery systems (super-SNEDDS) enhance the bioavailability of the poorly water-soluble drug Simvastatin in dogs

, 2013
This study investigates the potential of supersaturated self-nanoemulsifying drug delivery systems (super-SNEDDS) to improve the bioavailability of poorly water-soluble drugs compared to conventional SNEDDS. Conventional SNEDDS contained simvastatin (SIM)
Karlsson, Jens Jakob, Holm, R., Holm, René, Garmer, Mats, Thomas, N., Karlsson, J.J., Müllertz, A., Thomas, Nicky, Müllertz, Anette, Garmer, M., Rades, T., Rades, Thomas   +11 more
core   +1 more source

SOLUBILITY AND THERMODYNAMIC MODELING OF QUETIAPINE FUMARATE IN SELF NANOEMULSIFYING DRUG DELIVERY SYSTEM (SNEDDS) [PDF]

, 2018
Objective: The present study gives emphasis on the development of self-nanoemulsifying drug delivery system (SNEDDS) of poorly water-soluble drug using Apelblat model.
Talele, S. G., Derle, D. V.
core   +1 more source

Characterization and Optimization of Capryol-90, Polysorbate-80, And Peg-400 Proportion in Mefenamic Acid Self Nanoemulsifying Drug Delivery System (SNEDDS) With Simplex-Lattice-Design

Science and Technology Indonesia, 2018
Mefenamic acid as pain relief drug belongs to the biopharmaceutics classification system (BCS) class II which is practically insoluble in water causing extremely low dissolution in gastrointestinal tract.
Mardiyanto Mardiyanto, Najma Annuria Fithri, Martina Tandry   +2 more
doaj   +1 more source

Design, Optimization, and Solidification of Atazanavir-Loaded Self-Nanoemulsifying Drug Delivery System (SNEDDS) for Enhanced Oral Bioavailability [PDF]

The present study aimed to enhance the oral bioavailability of atazanavir sulfate, a BCS Class II antiretroviral drug characterized by poor aqueous solubility, through development of a solid self-nanoemulsifying drug delivery system (S-SNEDDS).
Khatri, Kavitha AN
core  

Self-Nanoemulsifying Drug Delivery System of Genkwanin: A Novel Approach for Anti-Colitis-Associated Colorectal Cancer

Drug Design, Development and Therapy, 2021
Hua-Feng Yin,1,2 Chun-Ming Yin,3 Ting Ouyang,4 Shu-Ding Sun,1 Wei-Guo Chen,1 Xiao-Lin Yang,5 Xin He,6 Chun-Feng Zhang1 1School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing, 210009, Jiangsu, People’s Republic of China ...
Yin HF, Yin CM, Ouyang T, Sun SD, Chen WG, Yang XL, He X, Zhang CF   +7 more
doaj  

Formulation Development of Solid Self-Nanoemulsifying Drug Delivery Systems of Quetiapine Fumarate via Hot-Melt Extrusion Technology: Optimization Using Central Composite Design

Pharmaceutics
Quetiapine fumarate (QTF) was approved for the treatment of schizophrenia and acute manic episodes. QTF can also be used as an adjunctive treatment for major depressive disorders. QTF oral bioavailability is limited due to its poor aqueous solubility and
Prateek Uttreja, Ahmed Adel Ali Youssef, Indrajeet Karnik, Kavish Sanil, Nagarjuna Narala, Honghe Wang, Rasha M. Elkanayati, Sateesh Kumar Vemula, Michael A. Repka   +8 more
doaj   +1 more source

Comparisons of in vitro Fick’s first law, lipolysis, and in vivo rat models for oral absorption on BCS II drugs in SNEDDS

International Journal of Nanomedicine, 2019
Jingyi Ye,1,* Huiyi Wu,1,* Chuanli Huang,1 Wanting Lin,2 Caifeng Zhang,1 Bei Huang,2 Banyi Lu,2 Hongyu Xu,2 Xiaoling Li,3 Xiaoying Long1,41Department of Pharmaceutics, School of Pharmacy, Guangdong Pharmaceutical University, Guangzhou 510006, People&
Ye J, Wu H, Huang C, Lin W, Zhang C, Huang B, Lu B, Xu H, Li X, Long X   +9 more
doaj  

Optimization of Glibenclamide Loaded Thermoresponsive SNEDDS Using Design of Experiment Approach: Paving the Way to Enhance Pharmaceutical Applicability

Molecules
Thermoresponsive self-nanoemulsifying drug delivery systems (T-SNEDDS) offer a promising solution to the limitations of conventional SNEDDS formulations.
Abdelrahman Y. Sherif, Ehab M. Elzayat, Mohammad A. Altamimi   +2 more
doaj   +1 more source

Development of Curcumin and Piperine-Loaded Bio-Active Self-Nanoemulsifying Drugs and Investigation of Their Bioactivity in Zebrafish Embryos and Human Hematological Cancer Cell Lines

International Journal of Nanomedicine, 2023
Mohsin Kazi,1 Muhammad Farooq Khan,2 Fahd A Nasr,3 Mohammad Z Ahmed,3 Ali S Alqahtani,3 Meser M Ali,4 Mohammed S Aldughaim5 1Department of Pharmaceutics, College of Pharmacy, King Saud University, Riyadh, 11451, Kingdom of Saudi Arabia; 2Department of ...
Kazi M, Khan MF, Nasr FA, Ahmed MZ, Alqahtani AS, Ali MM, Aldughaim MS   +6 more
doaj