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The S100 protein family: History, function, and expression
Brain Research Bulletin, 1995The S100 family of calcium binding proteins contains approximately 16 members each of which exhibits a unique pattern of tissue/cell type specific expression. Although the distribution of these proteins is not restricted to the nervous system, the implication of several members of this family in nervous system development, function, and disease has ...
D B, Zimmer +3 more
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Evolution of the S100 family of calcium sensor proteins
Cell Calcium, 2013The S100s are a large group of Ca(2+) sensors found exclusively in vertebrates. Transcriptomic and genomic data from the major radiations of mammals were used to derive the evolution of the mammalian S100s genes. In human and mouse, S100s and S100 fused-type proteins are in a separate clade from other Ca(2+) sensor proteins, indicating that an ancient ...
Danna B, Zimmer +3 more
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The S100 family of multipurpose calcium‐binding proteins
Journal of Cutaneous Pathology, 1998Antibodies reactive with S100 protein are useful markers in a diagnostic immunohistochemistry laboratory dealing with cutaneous tumors. However, S100 protein is not a single protein but instead a group of S100 proteins with diverse functions. S100 proteins constitute a family of acidic calcium‐binding proteins that are important in intracellular ...
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The S100 family of EF-hand calcium-binding proteins: functions and pathology
Trends in Biochemical Sciences, 1996Calcium lons as second messengers control many biological processes, at least in part, via interaction with a large number of Ca(2+)-binding proteins. One class of these proteins shares a common Ca(2+)-binding motif, the EF-hand, Here, we describe some functional aspects of EF-hand proteins, which have been found recently in different cellular ...
Schäfer BW, Heizmann CW
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A Search for Inhibitors of S100B, a Member of the S100 Family of Calcium-Binding Proteins
Mini-Reviews in Medicinal Chemistry, 2007Typically, malignant melanoma has wild-type p53, and yet this cancer proliferates. S100B, which binds p53 and is up-regulated in melanoma, down-regulates wild-type p53 tumor suppressor function. Inhibitors of the S100B-p53 interaction were identified using computer aided drug design (CADD) combined with NMR methodologies and represent potentially new ...
Joseph, Markowitz +2 more
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Conditioning solid tumor microenvironment through inflammatory chemokines and S100 family proteins
Cancer Letters, 2015Recently, there has been growing attention to the role of the tumor microenvironment (TME) in cancer growth, metastasis and emergence of chemotherapy resistance. Stromal and tumor cells make up the TME and interact with each other through a complex cross-talk manner.
Mohd W, Nasser +3 more
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Mechanisms of Action of the S100 Family of Calcium Modulated Proteins
1988Eukaryotic cells require calcium ions for optimal growth and functioning. The intracellular actions of calcium as a biological second messenger appear to be a result of its interaction with a set of calcium binding proteins referred to as calcium-modulated proteins (Van Eldik et al. 1982).
L. J. Van Eldik, D. B. Zimmer
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S100 protein family and its application in clinical practice.
Hippokratia, 2011The members of the S100 protein family are multifunctional proteins with a regulatory role in a variety of cellular processes. They exert their actions usually through calcium binding, although Zn2+ and Cu2+ have also been shown to regulate their biological activity.
F, Sedaghat, A, Notopoulos
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The S100 protein family and its application in cardiac diseases.
World journal of emergency medicine, 2014The S100 protein family is the largest group of EF-hand signaling proteins in humans. The members of the S100 protein family are expressed in many tissues and play different functions. Many diseases are related to S100 proteins, which function as new biochemical markers especially in cardiac diseases. The most studied members, protein S100B and protein
Xiu-Jie, Wang, Man, Wang
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Comparative Biochemistry of Drug-Binding Proteins in Calmodulin/S100 Family
1983A thesis presented to the faculty of The Rockefeller University in partial fulfillment of the requirements for the degree of Doctor of ...
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