Multifunctional Role of S100 Protein Family in the Immune System: An Update
Cells, 2022 S100 is a broad subfamily of low-molecular weight calcium-binding proteins (9–14 kDa) with structural similarity and functional discrepancy. It is required for inflammation and cellular homeostasis, and can work extracellularly, intracellularly, or both.
Parul Singh, Syed Azmal Ali
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Intrinsically disordered and aggregation prone regions underlie β-aggregation in S100 proteins. [PDF]
PLoS ONE, 2013 S100 proteins are small dimeric calcium-binding proteins which control cell cycle, growth and differentiation via interactions with different target proteins.
Sofia B Carvalho +5 more
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Both Ca2+ and Zn2+ are essential for S100A12 protein oligomerization and function [PDF]
, 2009 Background Human S100A12 is a member of the S100 family of EF-hand calcium-modulated proteins that are associated with many diseases including cancer, chronic inflammation and neurological disorders.
Moroz, Olga V. +13 more
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Transcriptomic and ChIP-sequence interrogation of EGFR signaling in HER2+ breast cancer cells reveals a dynamic chromatin landscape and S100 genes as targets. [PDF]
, 2019 BACKGROUND:The Human Epidermal Growth Factor Receptor (EGFR/HER1) can be activated by several ligands including Transforming Growth Factor alpha (TGF-α) and Epidermal Growth Factor (EGF).
Dutta, Pranabananda +5 more
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Membrane interactions of S100A12 (Calgranulin C) [PDF]
, 2013 S100A12 (Calgranulin C) is a small acidic calcium-binding peripheral membrane protein with two EF-hand structural motifs. It is expressed in macrophages and lymphocytes and highly up-regulated in several human inflammatory diseases.
Araujo, A.P.U. +5 more
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Significance of Elecsys (R) S100 immunoassay for real-time assessment of traumatic brain damage in multiple trauma patients [PDF]
, 2006 Background: The neuroprotein S100 released into the circulation has been suggested as a reliable marker for primary brain damage. However, safe identification of relevant traumatic brain injury (TBI) may possibly be hampered by S100 release from ...
Alber +38 more
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Physicochemical analysis of rotavirus segment 11 supports a 'modified panhandle' structure and not the predicted alternative tRNA-like structure (TRLS) [PDF]
, 2013 .Rotaviruses are a major cause of acute gastroenteritis, which is often fatal in infants. The viral genome consists of 11 double-stranded RNA segments, but little is known about their cis-acting sequences and structural elements.
A Heerschap +47 more
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Exclusive neuronal expression of SUCLA2 in the human brain [PDF]
, 2013 SUCLA2 encodes the ATP-forming subunit (A-SUCL-) of succinyl-CoA ligase, an enzyme of the citric acid cycle. Mutations in SUCLA2 lead to a mitochondrial disorder manifesting as encephalomyopathy with dystonia, deafness and lesions in the basal ganglia ...
A Kowluru +55 more
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Study of serum levels and skin expression of S100B protein in psoriasis [PDF]
Anais Brasileiros de Dermatologia, 2017 Background: S100B protein was reported to be elevated in psoriatic patients' serum, with no previous evaluation of its skin expression, in contrast to the extensively studied S100 protein.
Samar Abdallah M. Salem +6 more
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Evolutionary origin and diversification of epidermal barrier proteins in amniotes. [PDF]
, 2014 The evolution of amniotes has involved major molecular innovations in the epidermis. In particular, distinct structural proteins that undergo covalent cross-linking during cornification of keratinocytes facilitate the formation of mechanically resilient ...
Alibardi, Lorenzo +7 more
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