Results 21 to 30 of about 62,178 (258)
S100 proteins in mammary gland regulation and their role in breast cancer metastasis
Advances in Cancer Biology - Metastasis, 2023 S100 proteins have emerged as key regulators in the mammary gland and have been implicated in breast cancer development and metastasis. This review provides a comprehensive overview of the roles of S100 proteins in mammary gland regulation and their ...
Parul Singh, Syed Azmal Ali
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S100 Proteins in the Epidermis [PDF]
Journal of Investigative Dermatology, 2004 The S100 proteins comprise a family of 21 low molecular weight (9-13 kDa) proteins that are characterized by the presence of two calcium-binding EF-hand motifs. Fourteen S100 protein genes are located within the epidermal differentiation complex on human chromosome 1q21 and 13 S100 proteins (S100A2, S100A3, S100A4, S100A6, S100A7, S100A8, S100A9 ...
Eckert, Richard L. +5 more
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Multiple Evolutionary Origins of Ubiquitous Cu2+ and Zn2+ Binding in the S100 Protein Family. [PDF]
PLoS ONE, 2016 The S100 proteins are a large family of signaling proteins that play critical roles in biology and disease. Many S100 proteins bind Zn2+, Cu2+, and/or Mn2+ as part of their biological functions; however, the evolutionary origins of binding remain obscure.
Lucas C Wheeler +3 more
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Promiscuity mapping of the S100 protein family using a high-throughput holdup assay
Scientific Reports, 2022 S100 proteins are small, typically homodimeric, vertebrate-specific EF-hand proteins that establish Ca2+-dependent protein–protein interactions in the intra- and extracellular environment and are overexpressed in various pathologies.
Márton A. Simon +8 more
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Binding of transition metals to S100 proteins [PDF]
Science China Life Sciences, 2016 Benjamin A Gilston +2 more
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Influence of S100A2 in Human Diseases
Diagnostics, 2022 S100 proteins are a family of low-molecular-weight proteins characterized by two calcium-binding sites with a helix-loop-helix (“EF-hand-type”) domain.
Hitomi Sugino, Yu Sawada
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Nutritional Immunity: S100 Proteins at the Host-Pathogen Interface [PDF]
Journal of Biological Chemistry, 2015 Joseph P Zackular +2 more
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Certainty of S100 from Physiology to Pathology [PDF]
Journal of Clinical and Diagnostic Research, 2016 S100 exists in wide variety of tissues and cell types, originally isolated from brain tissue and they are of low molecular weight proteins. S100 is evenly distributed in cytoplasm and also in nucleoplasm and is involved in both intercellular and ...
Puneeth Horatti Kuberappa +4 more
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S100s and HMGB1 Crosstalk in Pancreatic Cancer Tumors
Biomolecules, 2023 Pancreatic cancer remains a disease that is very difficult to treat. S100 proteins are small calcium binding proteins with diverse intra- and extracellular functions that modulate different aspects of tumorigenesis, including tumor growth and metastasis.
Angelo Mandarino +5 more
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S100A6 protein negatively regulates CacyBP/SIP-mediated inhibition of gastric cancer cell proliferation and tumorigenesis. [PDF]
PLoS ONE, 2012 Calcyclin-binding protein (CacyBP/SIP), identified on the basis of its ability to interact with S100 proteins in a calcium-dependent manner, was previously found to inhibit the proliferation and tumorigenesis of gastric cancer cells in our laboratory ...
Xiaoxuan Ning +6 more
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