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Relationship of S100 Proteins with Neuroinflammation [PDF]
BiomoleculesS100 proteins, a family of Ca2+-binding proteins, play numerous roles in cellular processes such as proliferation, differentiation, and apoptosis. Recent evidence has highlighted their critical involvement in neuroinflammation, a pathological hallmark of
Mario García-Domínguez
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Nature Reviews Cancer, 2015 In humans, the S100 protein family is composed of 21 members that exhibit a high degree of structural similarity, but are not functionally interchangeable. This family of proteins modulates cellular responses by functioning both as intracellular Ca(2+) sensors and as extracellular factors.
Anne R Bresnick
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Functions of S100 Proteins [PDF]
Current Molecular Medicine, 2013 The S100 protein family consists of 24 members functionally distributed into three main subgroups: those that only exert intracellular regulatory effects, those with intracellular and extracellular functions and those which mainly exert extracellular regulatory effects.
Rosario Donato, Guglielmo Sorci
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A review on clinical implications of S100 proteins in lung diseases [PDF]
Frontiers in MedicineThe S100 family of proteins plays a pivotal role in the pathogenesis of lung diseases, including asthma, chronic obstructive pulmonary disease (COPD), cystic fibrosis, pulmonary arterial hypertension (PAH), pulmonary fibrosis, lung cancers, acute lung ...
Vineesh V. Raveendran +2 more
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Role of S100 Proteins in Colorectal Carcinogenesis [PDF]
Gastroenterology Research and Practice, 2016 The family of S100 proteins represents 25 relatively small (9–13 kD) calcium binding proteins. These proteins possess a broad spectrum of important intracellular and extracellular functions. Colorectal cancer is the third most common cancer in men (after
Paula Moravkova +4 more
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The use of S100 proteins testing in juvenile idiopathic arthritis and autoinflammatory diseases in a pediatric clinical setting: a retrospective analysis [PDF]
Pediatric Rheumatology Online Journal, 2020 Background Serum phagocyte-derived alarmins S100A8/9 and S100A12 are considered useful for the assessment of inflammatory diseases. Our study evaluated the use of S100 proteins in a pediatric clinical setting for estimating disease activity and ...
Najla Aljaberi +7 more
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S100 proteins: a new frontier in fibromyalgia research [PDF]
Molecular BrainFibromyalgia (FM) is a chronic condition that causes widespread pain, fatigue, and other symptoms that significantly affect quality of life. The underlying mechanisms of fibromyalgia involve both the immune system and the central nervous system.
María Teresa Vega-Ramírez +4 more
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Urine S100 proteins as potential biomarkers of lupus nephritis activity [PDF]
Arthritis Research & Therapy, 2017 Background Improved, noninvasive biomarkers are needed to accurately detect lupus nephritis (LN) activity. The purpose of this study was to evaluate five S100 proteins (S100A4, S100A6, S100A8/9, and S100A12) in both serum and urine as potential ...
Jessica L. Turnier +8 more
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Friend or Foe: S100 Proteins in Cancer [PDF]
Cancers, 2020 Chantal Allgöwer +2 more
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S100 proteins as therapeutic targets. [PDF]
Biophys Rev, 2018 The human genome codes for 21 S100 protein family members, which exhibit cell- and tissue-specific expression patterns. Despite sharing a high degree of sequence and structural similarity, the S100 proteins bind a diverse range of protein targets and contribute to a broad array of intracellular and extracellular functions.
Bresnick AR.
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