Role of S100 Proteins in Colorectal Carcinogenesis [PDF]
Gastroenterology Research and Practice, 2016 The family of S100 proteins represents 25 relatively small (9–13 kD) calcium binding proteins. These proteins possess a broad spectrum of important intracellular and extracellular functions. Colorectal cancer is the third most common cancer in men (after
Paula Moravkova +4 more
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A feedback loop sustaining neutrophil extracellular trap formation involves S100 proteins, histones, TLR2 and RAGE, and is restrained by albumin [PDF]
Frontiers in ImmunologyNeutrophil extracellular trap (NET) generation must be tightly controlled as this essential antimicrobial response can also cause tissue damage and contribute to various pathologies.
Vanessa de Carvalho Oliveira +4 more
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The use of S100 proteins testing in juvenile idiopathic arthritis and autoinflammatory diseases in a pediatric clinical setting: a retrospective analysis [PDF]
Pediatric Rheumatology Online Journal, 2020 Background Serum phagocyte-derived alarmins S100A8/9 and S100A12 are considered useful for the assessment of inflammatory diseases. Our study evaluated the use of S100 proteins in a pediatric clinical setting for estimating disease activity and ...
Najla Aljaberi +7 more
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S100 proteins: a new frontier in fibromyalgia research [PDF]
Molecular BrainFibromyalgia (FM) is a chronic condition that causes widespread pain, fatigue, and other symptoms that significantly affect quality of life. The underlying mechanisms of fibromyalgia involve both the immune system and the central nervous system.
María Teresa Vega-Ramírez +4 more
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Urine S100 proteins as potential biomarkers of lupus nephritis activity [PDF]
Arthritis Research & Therapy, 2017 Background Improved, noninvasive biomarkers are needed to accurately detect lupus nephritis (LN) activity. The purpose of this study was to evaluate five S100 proteins (S100A4, S100A6, S100A8/9, and S100A12) in both serum and urine as potential ...
Jessica L. Turnier +8 more
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Friend or Foe: S100 Proteins in Cancer [PDF]
Cancers, 2020 Doris Henne-Bruns +2 more
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S100 proteins in mammary gland regulation and their role in breast cancer metastasis
Advances in Cancer Biology - Metastasis, 2023 S100 proteins have emerged as key regulators in the mammary gland and have been implicated in breast cancer development and metastasis. This review provides a comprehensive overview of the roles of S100 proteins in mammary gland regulation and their ...
Parul Singh, Syed Azmal Ali
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Multiple Evolutionary Origins of Ubiquitous Cu2+ and Zn2+ Binding in the S100 Protein Family. [PDF]
PLoS ONE, 2016 The S100 proteins are a large family of signaling proteins that play critical roles in biology and disease. Many S100 proteins bind Zn2+, Cu2+, and/or Mn2+ as part of their biological functions; however, the evolutionary origins of binding remain obscure.
Lucas C Wheeler +3 more
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Promiscuity mapping of the S100 protein family using a high-throughput holdup assay
Scientific Reports, 2022 S100 proteins are small, typically homodimeric, vertebrate-specific EF-hand proteins that establish Ca2+-dependent protein–protein interactions in the intra- and extracellular environment and are overexpressed in various pathologies.
Márton A. Simon +8 more
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Influence of S100A2 in Human Diseases
Diagnostics, 2022 S100 proteins are a family of low-molecular-weight proteins characterized by two calcium-binding sites with a helix-loop-helix (“EF-hand-type”) domain.
Hitomi Sugino, Yu Sawada
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