Results 41 to 50 of about 61,394 (264)

Emergence of highly profibrotic and proinflammatory Lrat+Fbln2+ HSC subpopulation in alcoholic hepatitis

Hepatology, EarlyView., 2022
Lrat+ quiescent hepatic stellate cells (qHSC) give rise to Lrat+Fbln2+ activated HSC (aHSC) in alcohol‐associated hepatitis and this subpopulation is highly profibrotic, inflammatory, and immunoregulatory based on their single cell transcriptomic profile. Abstract Background and Aims Relative roles of HSCs and portal fibroblasts in alcoholic hepatitis (
Steven Balog, Reika Fujiwara, Stephanie Q. Pan, Khairat B. El‐Baradie, Hye Yeon Choi, Sonal Sinha, Qihong Yang, Kinji Asahina, Yibu Chen, Meng Li, Matthew Salomon, Stanley W.‐K. Ng, Hidekazu Tsukamoto   +12 more
wiley   +1 more source

Transcriptomic and ChIP-sequence interrogation of EGFR signaling in HER2+ breast cancer cells reveals a dynamic chromatin landscape and S100 genes as targets. [PDF]

, 2019
BACKGROUND:The Human Epidermal Growth Factor Receptor (EGFR/HER1) can be activated by several ligands including Transforming Growth Factor alpha (TGF-α) and Epidermal Growth Factor (EGF).
Dutta, Pranabananda, Farias-Eisner, Robin, Nava, Miguel, Vadgama, Jaydutt V, Wu, Yanyuan, Zemke, Nathan R   +5 more
core   +5 more sources

Interaction of S100A6 Protein with the Four-Helical Cytokines

Biomolecules, 2023
S100 is a family of over 20 structurally homologous, but functionally diverse regulatory (calcium/zinc)-binding proteins of vertebrates. The involvement of S100 proteins in numerous vital (patho)physiological processes is mediated by their interaction ...
Alexey S. Kazakov, Evgenia I. Deryusheva, Victoria A. Rastrygina, Andrey S. Sokolov, Maria E. Permyakova, Ekaterina A. Litus, Vladimir N. Uversky, Eugene A. Permyakov, Sergei E. Permyakov   +8 more
doaj   +1 more source

Gasdermin pores permeabilize mitochondria to augment caspase-3 activation during apoptosis and inflammasome activation. [PDF]

, 2019
Gasdermin E (GSDME/DFNA5) cleavage by caspase-3 liberates the GSDME-N domain, which mediates pyroptosis by forming pores in the plasma membrane.
Alnemri, Emad S., Aplin, Andrew E., Erkes, Dan A., Fernandes-Alnemri, Teresa, Nardone, Alexandria, Rogers, Corey   +5 more
core   +3 more sources

Large-scale proteomic identification of S100 proteins in breast cancer tissues

BMC Cancer, 2010
Background Attempts to reduce morbidity and mortality in breast cancer is based on efforts to identify novel biomarkers to support prognosis and therapeutic choices.
Cancemi Patrizia, Di Cara Gianluca, Albanese Nadia, Costantini Francesca, Marabeti Maria, Musso Rosa, Lupo Carmelo, Roz Elena, Pucci-Minafra Ida   +8 more
doaj   +1 more source

S100 Calcium-Binding Proteins and Ion Channels

Frontiers in Pharmacology, 2012
S100 Ca2+-binding proteins have been associated with a multitude of intracellular Ca2+-mediated functions including regulation of the cell cycle, cell differentiation, cell motility and apoptosis, modulation of membrane-cytoskeletal interactions ...
Anton eHermann, Rosario eDonato, Thomas M. Weiger, Walter J. Chazin   +3 more
doaj   +1 more source

Role of S100 family proteins in colorectal cancer (CRC): an overview of their potential function as new biomarkers and therapeutic agents

Expert Reviews in Molecular Medicine
Colorectal cancer (CRC) is the second deadliest cancer worldwide, posing a great threat to human health and a social burden. Various genetic and epigenetic alterations can activate tumourigenesis-related signalling pathways, leading to CRC development ...
Hamideh Raeisi, Leili Rejali, Nayeralsadat Fatemi, Amir Sadeghi, Zahra Sadeghloo, Mohammad Reza Zali, Ehsan Nazemalhosseini Mojarad   +6 more
doaj   +1 more source

PAX2 regulates ADAM10 expression and mediates anchorage-independent cell growth of melanoma cells [PDF]

, 2011
PAX transcription factors play an important role during development and carcinogenesis. In this study, we investigated PAX2 protein levels in melanocytes and melanoma cells by Western Blot and immunofluorescence analysis and characterized the role of ...
Lee, Sophia Boyoung, Doberstein, Kai, Baumgarten, Peter, Wieland, Anja, Ungerer, Christopher, Bürger, Claudia, Hardt, Katja, Boehncke, Wolf-Henning, Pfeilschifter, Josef (Prof. Dr.), Mihic-Probst, Daniela, Mittelbronn, Michel Guy André, Gutwein, Paul   +11 more
core   +2 more sources

S100 Proteins in the Epidermis [PDF]

Journal of Investigative Dermatology, 2004
The S100 proteins comprise a family of 21 low molecular weight (9-13 kDa) proteins that are characterized by the presence of two calcium-binding EF-hand motifs. Fourteen S100 protein genes are located within the epidermal differentiation complex on human chromosome 1q21 and 13 S100 proteins (S100A2, S100A3, S100A4, S100A6, S100A7, S100A8, S100A9 ...
Eckert, Richard L., Broome, Ann-Marie, Ruse, Monica, Robinson, Nancy, Ryan, David, Lee, Kathleen   +5 more
openaire   +2 more sources

Role of the S100 protein family in rheumatoid arthritis

Arthritis Research & Therapy, 2022
Rheumatoid arthritis is a chronic systemic autoimmune disease characterized by synovial hyperplasia, inflammatory cell infiltration, and proliferation of inflammatory tissue (angiogranuloma).
Yuan-yuan Wu, Xiao-feng Li, Sha Wu, Xue-ni Niu, Su-qin Yin, Cheng Huang, Jun Li   +6 more
doaj   +1 more source