Results 121 to 130 of about 878,063 (323)

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Identification and Characterization of the PEBP Family Genes in Moso Bamboo (Phyllostachys heterocycla). [PDF]

, 2019
Moso bamboo is one of the economically most important plants in China. Moso bamboo is a monocarpic perennial that exhibits poor and slow germination. Thus, the flowering often causes destruction of moso bamboo forestry.
Chen, Lei, Gu, Lianfeng, Kohnen, Markus V, Liao, Jiakai, Lin, Chentao, Liu, Bobin, Oka, Yoshito, Xiong, Bei, Yang, Zhaohe, Zhen, Xi, Zhu, Qiang   +10 more
core  

Identification and characterization of vp7 gene in Bombyx mori cytoplasmic polyhedrosis virus

Gene, 2017
The genome of Bombyx mori cytoplasmic polyhedrosis virus (BmCPV) contains 10 double stranded RNA segments (S1–S10). The segment 7 (S7) encodes 50kDa protein which is considered as a structural protein.
Lei He, Xiaolong Hu, Min Zhu, Zi Liang, Fei Chen, Liyuan Zhu, Sulan Kuang, G. Cao, Renyu Xue, C. Gong   +9 more
semanticscholar   +1 more source

Characterization of a recombinant coronavirus infectious bronchitis virus with distinct S1 subunits of spike and nucleocapsid genes and a 3′ untranslated region

Veterinary Microbiology, 2013
An infectious bronchitis virus (IBV), ck/CH/LZJ/111113, was isolated from a H120-vaccinated chicken which showed disease suspected of IBV infection. Neutralization testing showed that ck/CH/LZJ/111113 was distinct from either the Chinese predominant IBV LX4-type or Mass-type vaccine strains.
Liu, Xiaoli, Ma, Huijie, Xu, Qianqian, Sun, Nana, Han, Zongxi, Sun, Chuyang, Guo, Hongbo, Shao, Yuhao, Kong, Xiangang, Liu, Shengwang   +9 more
openaire   +2 more sources

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Additional file 1: Table S1. of Identification and functional characterization of the sulfate transporter gene GmSULTR1;2b in soybean

, 2016
Information concerning the 28 soybean SULTR genes. Table S2. Accession numbers of putative SULTR protein sequences. Figure S1. In silico expression profiling of 28 soybean SULTR genes in 10 soybean tissues. Figure S2. Alignment of SULTR protein sequences. Figure S3. Subcellular localization of GmSULTR1;2b. Figure S4.
Yiqiong Ding, Xiaoqiong Zhou, Zuo, Li, Wang, Hui, Deyue Yu   +4 more
openaire   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Synthesis and characterization of microbial fructosyltransferase (FTase) from endophytic Bacillus stercoris S1 for fructooligosaccharide production

Annals of Microbiology
Purpose Presently, there is a rising awareness of the additional health benefits and market potential for functional foods. Among various functional foods short chain Fructooligosaccharides (FOS) have make its prestige in food industry.
Neha Gautam, Puneet Kumar, Stuti Sharma, Vikas Kumar, Shruti Gupta   +4 more
doaj   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Identification of Reassortant Mammalian Orthoreovirus Strains in European Hedgehogs (Erinaceus europaeus): Genomic Insights and Host Association

Microorganisms
Thanks to its ethological and physiological characteristics, the hedgehog is a synanthropic species of particular importance for the maintenance and possible spread of pathogens, some of which are zoonotic.
Tiziana Trogu, Maya Carrera, Clara Tolini, Ambra Nucci, Sabrina Canziani, Guido Grilli, Maria Cristina Rapi, Sara Manfredini, Silva Rubini, Davide Lelli, Valentina Carta, Cristina Bertasio, Enrica Sozzi, Antonio Lavazza, Ana Moreno   +14 more
doaj   +1 more source