Results 131 to 140 of about 878,063 (323)

Additional file 7: Figure S1. of Identification, characterization, and gene expression analysis of nucleotide binding site (NB)-type resistance gene homologues in switchgrass

, 2016
Labeled phylogenetic tree of 578 switchgrass RGHs and 116 Brachypodium distachyon RGHs. Figure S1 is a replica of the phylogenetic tree included in the paper but it contains the IDs of the 578 switchgrass RGHs and 116 Brachypodium distachyon RGHs. (PDF 820 kb)
Frazier, Taylor, Palmer, Nathan, Fuliang Xie, Tobias, Christian, Donze-Reiner, Teresa, Bombarely, Aureliano, Childs, Kevin, Shengqiang Shu, Jenkins, Jerry, Schmutz, Jeremy, Baohong Zhang, Sarath, Gautam, Bingyu Zhao   +12 more
openaire   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Prevalence and Molecular Characterization of Porcine Parvovirus 2 in Southwest China During 2020–2023

Veterinary Sciences
Porcine parvovirus (PPV) is a non-enveloped, single-stranded linear DNA virus that induces reproductive disorders in sows, particularly abortions in primiparous sows.
Hongyu Chen, Yi Qing, Lei Xu, Ling Zhu, Wenqi Yin, Shuwei Li, Shengyao Kuang, Yuancheng Zhou, Zhiwen Xu   +8 more
doaj   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Genome Diversity, Recombination, and Virulence across the Major Lineages of Paracoccidioides

mSphere, 2016
The Paracoccidioides genus includes two species of thermally dimorphic fungi that cause paracoccidioidomycosis, a neglected health-threatening human systemic mycosis endemic to Latin America.
José F. Muñoz, Rhys A. Farrer, Christopher A. Desjardins, Juan E. Gallo, Sean Sykes, Sharadha Sakthikumar, Elizabeth Misas, Emily A. Whiston, Eduardo Bagagli, Celia M. A. Soares, Marcus de M. Teixeira, John W. Taylor, Oliver K. Clay, Juan G. McEwen, Christina A. Cuomo   +14 more
doaj   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

The reovirus variant RP116 is oncolytic in immunocompetent models and generates reduced neutralizing antibodies to Type 3 Dearing

Molecular Therapy: Oncology
The mammalian reovirus Type 3 Dearing (T3D) is a naturally occurring oncolytic virus. We previously identified a T3D variant isolated from persistently infected cancer cells that has a premature stop codon mutation in the S1 gene, generating a truncated ...
Ki-Hoon Song, Xiao Xiang, So Hyun Lee, Jong Kyu Woo, Gansukh Enkhtaivan, Carlos Rios Giraldo, You-Rim Lee, Yeo Jin Jeong, Salar Pashangzadeh, Negar Sharifi, An-Dao Yang, Huy-Dung Hoang, Nam-Hyuk Cho, Yeon-Sook Lee, Dong Guk Park, Tommy Alain   +15 more
doaj   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Additional file 2: Table S1. of Molecular and Bioinformatic Characterization of the Rice ROOT UV-B SENSITIVE Gene Family

, 2016
Primers for cloning of 6 OsRUS cDNAs. (DOCX 16Â kb)
Yu, Ning, Yaping Liang, Xinxiang Peng, Xuewen Hou   +3 more
openaire   +1 more source

Tumor mutational burden as a determinant of metastatic dissemination patterns

Molecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal, Andrea Moreno‐Manuel, Miguel Salvadó‐Pertierra, Cristina Santos‐Vivas, Rebeca Sanz‐Pamplona   +4 more
wiley   +1 more source