Results 61 to 70 of about 10,942 (178)

Radiotherapy‐Induced Otitis Media With Effusion in Nasopharyngeal Carcinoma: A Meta‐Analysis

The Laryngoscope, Volume 136, Issue 9, Page 3718-3731, September 2026.
This meta‐analysis of eight studies comprising 582 NPC patients provides the first quantitative synthesis of radiotherapy‐induced otitis media with effusion (OME), demonstrating a significant overall risk difference of 0.18 (95% CI: −0.06 to 0.42, p < 0.0001) in OME naive ears.
Nevin Yi Meng Chua, Yong Hoe Chan, Woei Shyang Loh, De Yun Wang   +3 more
wiley   +1 more source

The Six Pillars of Lifestyle Medicine in MASLD: An Evidence‐Based Guide

Liver International Communications, Volume 7, Issue 3, September 2026.
ABSTRACT Metabolic dysfunction–associated steatotic liver disease (MASLD) is the most common chronic liver disease worldwide and is projected to affect more than 40% of adults by 2050. Although pharmacologic therapies are emerging, lifestyle modification remains the foundation of management.
Jigyasa Sharma, Kathleen Viveiros
wiley   +1 more source

APLICAÇÃO DA ESPECTROSCOPIA NO INFRAVERMELHO E DIFRAÇÃO DE RAIO-X NA DETERMINAÇÃO DE SACARINA EM ADOÇANTES LÍQUIDOS ARTIFICIAIS PELO MÉTODO VOLUMÉTRICO COM AG+

Eclética Química, 2018
The use of sweeteners liquid from saccharin sodium is a public health issue by the relationship with obesity and a source of sodium. The  levels of saccharin were studied in four different manufacturers in samples from trade in Vitória / ES, between ...
Jhonatas de Souza Lima, Mauro Cesar Dias, Túlio Matencio   +2 more
doaj   +1 more source

Molecular Dynamics Simulation of the Interaction of Saccharin with Human p53 Protein [PDF]

Armaghane Danesh Bimonthly Journal, 2023
Background & aim: The role of artificial sweeteners in the occurrence of cancer risk has been widely discussed during the last few decades. Therefore, the aim of the present study was to determine the dynamic and molecular simulation of the interaction ...
M Shahlai, M Mansourian
doaj  

Modulating Taste Perception in Newly Weaned Piglets: The Role of Palatability Additives in Enhancing Feed Intake and Performance

Animal Research and One Health, Volume 4, Issue 3, Page 240-246, August 2026.
Palatability enhancers modulate taste and smell, increasing feed acceptance, reducing weaning stress, and improving piglet performance. ABSTRACT The continuous growth of global agribusiness stimulates the search for alternatives that can enhance the performance and quality of life of production animals.
Luana Specht, Gabriela Altenhofen, Daiane Carvalho, Michele Fangmeier   +3 more
wiley   +1 more source

A Selective Cortico‐Limbic Network Organizes Behavior During Reward Seeking Under Threat

Journal of Neuroscience Research, Volume 104, Issue 8, August 2026.
In the SDAmC task, rats step down from safety and cross a threat‐associated context for saccharin. PL limits approach, pIC supports risk assessment, BLA supports avoidance across motivational states, and NAc supports goal‐directed behavior under conflict; IL, lOFC, aIC, and LHb showed no detectable effects.
Rodrigo O. Sierra, Leticia Ramirez‐Lugo, Elizabeth Illescas‐Huerta, Axel R. Bolaños, Francisco Sotres‐Bayon   +4 more
wiley   +1 more source

Preventive Effect of Antioxidant From Purple Rosella Yoghurt on Duodenum and Colon Histopathology of Rattus norvegicus Exposed to Rhodamine B And Saccharin

Journal of Experimental Life Science
Rodhamine B and Saccharin are often misused by food producers as food additive, which, if their use is not monitored, can produce free radicals that cause oxidative stress conditions in the body, leading to dangerous damage to the body.
Ajeng Erika Prihastuti Haskito, Bintari Nariswari, Anna Safitri, Aldila Noviatri, Handayu Untari, Citra Sari   +5 more
doaj   +1 more source

Pharmacological Inhibition of HDAC6 Transiently Reduces Voluntary Ethanol Consumption in Male Mice

Alcohol, Clinical and Experimental Research, Volume 50, Issue 8, August 2026.
The present study shows that systemic administration of the brain‐penetrant selective HDAC6 inhibitor bavarostat reduces voluntary ethanol drinking in male mice. This effect is dose‐dependent, selective for ethanol, independent of ethanol dependence, and transient.
Kiera Fleck, Jeffery L. Dunning, Max Kreifeldt, Catherine Lopez, Seokjun Jo, Edward Roberts, Candice Contet   +6 more
wiley   +1 more source

Saccharin disrupts bacterial cell envelope stability and interferes with DNA replication dynamics

EMBO Molecular Medicine
Saccharin has been part of the human diet for over 100 years, and there is a comprehensive body of evidence demonstrating that it can influence the gut microbiome, ultimately impacting human health. However, the precise mechanisms through which saccharin
Rubén de Dios, Kavita Gadar, Chris R Proctor, Evgenia Maslova, Jie Han, Mohamed A N Soliman, Dominika Krawiel, Emma L Dunbar, Bhupender Singh, Stelinda Peros, Tom Killelea, Anna-Luisa Warnke, Marius M Haugland, Edward L Bolt, Christian S Lentz, Christian J Rudolph, Ronan R McCarthy   +16 more
doaj   +1 more source

Sultams as Dual Inhibitors of Human Carbonic Anhydrase and Thioredoxin Reductase

ChemMedChem, Volume 21, Issue 14, 29 July 2026.
A series of sultam‐based N‐acyl derivatives with potential applications as dual TrxR1 and CA inhibitors were synthesized and evaluated. TrxR1 screening identified several active compounds, with inhibitory potency influenced by the type and orientation of substituents.
Aleksandrs Pustenko, Raitis Bobrovs, Venkatesan Saravanan, Kathir Avan, Simone Carradori, Antons Sizovs, Andrea Angeli, Claudiu T. Supuran, Raivis Žalubovskis   +8 more
wiley   +1 more source