Results 31 to 40 of about 84,845 (267)

A Chemical Framework for Engineering Extracellular Vesicles’ Biointerface to Advance Precision Therapeutics

Advanced Materials, EarlyView.
Extracellular vesicles (EVs) are cell‐derived nanoparticles that mediate intercellular communication through their dynamic biointerfaces. Owing to their intrinsic biological functions, EVs have emerged as promising platforms for biomedical applications.
Leila Pourtalebi Jahromi, Felix Geng, Jan‐Noël Frenzke, Gregor Fuhrmann   +3 more
wiley   +1 more source

One Health study of mobile colistin resistance (mcr) in Salmonella enterica in Canada, 2017–2022

Microbiology Spectrum
Colistin is a last-resort treatment for highly drug-resistant bacterial infections. Of 47,184 Salmonella isolates collected from 2017 to 2022 in Canada from human and animal/food sources, mobile colistin resistance (mcr) variants conferring colistin ...
Ketna Mistry, David Thumbi, Xiao Rui Li, Audrey Charlebois, Brent P. Avery, Anne E. Deckert, Ashley C. Cormier, Colleen Murphy, Ashley Kearney, Jennifer Campbell, Sara Christianson, David C. Alexander, Sameh El Bailey, Sadjia Bekal, Linda Chui, Xiaofeng Ding, Tanis Dingle, David Haldane, Linda Hoang, Jessica Minion, Samir Patel, George Zahariadis, Celine Nadon, Michael R. Mulvey, Carolee A. Carson, Richard J. Reid-Smith, Amrita Bharat   +26 more
doaj   +1 more source

Salmonella Schwarzengrund, Akuafo, and O:16 isolated from vacuum-packaged beef produced in the state of Mato Grosso, Brazil

Journal of Infection in Developing Countries, 2021
Introduction: Salmonella spp. is a pathogen associated with foodborne infections, mainly in foods of animal origin. In this context, the present study investigated the occurrence of Salmonella serotypes, genotypes and the antimicrobial resistance ...
Barbara Muller, Adelino Cunha-Neto, Vinicius Silva Castro, Ricardo Cesar Tavares Carvalho, Larrayane Albuês Carvalho Teixeira, Dalia dos Prazeres Rodrigues, Eduardo Eustáquio de Souza Figueiredo   +6 more
doaj   +1 more source

Engineering Microbial Particles for Next‐Generation Biomedical Platforms

Advanced Science, EarlyView.
Microbe‐derived particles (MDPs), which include extracellular vesicles, outer membrane vesicles, inclusion bodies, polysaccharide particles, and virus‐like particles, represent a rapidly expanding category of bioinspired nanomaterials. With their natural origin, intrinsic biocompatibility, and highly programmable functionality, MDPs serve as a ...
Yuting Li, Yunjie Lu, Ziyan Huang, Jianjiang Chen, Yanbin Liu, Lei Qin, Chao Wang, Yumin Wu   +7 more
wiley   +1 more source

Multi‐Targeting Carnosic Acid Kills Drug‐Resistant Helicobacter pylori With Narrow‐Spectrum Activity

Advanced Science, EarlyView.
Carnosic acid selectively eradicates drug‐resistant Helicobacter pylori through a multi‐targeted mechanism involving urease inhibition, membrane disruption, and biofilm eradication. It exhibits no detectable resistance, potent in vivo efficacy, and minimal impact on gut microbiota, positioning it as a promising narrow‐spectrum lead compound against ...
Yuefan Bai, Hongming Huang, Xudong Hang, Shanwei Hu, Qian Tong, Jingchen Xu, Jia Jia, Hongkai Bi   +7 more
wiley   +1 more source

Identification of a Nonribosomal Peptide Analog With Activity Against Multiple Gram‐Positive Bacteria via a Synthetic Bioinformatic Natural Product Discovery Approach

Advanced Science, EarlyView.
The genome of Rhodococcus erythropolis D‐1 was analyzed by bioinformatic tools to mine a novel nonribosomal peptide synthetase (NRPS) gene cluster. A nonribosomal peptide analog ZURJC5 associated with the NRPS was chemically synthesized. Through structure‐activity relationship studies, ZURJC28 was ultimately obtained and showed antibacterial activity ...
Keyi Chen, Jiayi Liang, Yujia Wu, Jianan Xu, Yi Liu, Wenguang Wang, Xinhang Jiang, Benjie Gao, Yueyue Wang, Hui Jiang   +9 more
wiley   +1 more source

Optimizing Poultry Nutrition to Combat Salmonella: Insights from the Literature

Microorganisms
Salmonella infections in poultry production are a significant and pervasive concern, posing substantial risks to both animal and human health. This comprehensive literature review examines the current body of research on the use of various nutritional ...
Muhammad Naeem, Dianna Bourassa
doaj   +1 more source

Targeting Lipopolysaccharide Transport Induces Membrane Lipid Remodeling and Sensitizes Acinetobacter baumannii to Colistin Treatment

Advanced Science, EarlyView.
This study identifies C4 as a lead inhibitor of the Lpt system. Notably, C4 potentiates colistin activity by disrupting LPS transport and remodeling phospholipid homeostasis, revealing a functional interplay between the Lpt and Mla systems. These findings establish a mechanistic link between Lpt inhibition and membrane lipid remodeling, positioning Lpt–
Jianya Luo, Hetianzi Zhang, Jinju Cai, Shuang Zhou, Haijie Zhang, Zhiqiang Wang, Yuan Liu   +6 more
wiley   +1 more source

A comparison of non-typhoidal Salmonella from humans and food animals using pulsed-field gel electrophoresis and antimicrobial susceptibility patterns.

PLoS ONE, 2013
Salmonellosis is one of the most important foodborne diseases affecting humans. To characterize the relationship between Salmonella causing human infections and their food animal reservoirs, we compared pulsed-field gel electrophoresis (PFGE) and ...
Carol H Sandt, Paula J Fedorka-Cray, Deepanker Tewari, Stephen Ostroff, Kevin Joyce, Nkuchia M M'ikanatha   +5 more
doaj   +1 more source

Virulence of invasive Salmonella Typhimurium ST313 in animal models of infection

PLOS Neglected Tropical Diseases, 2017
Salmonella Typhimurium sequence type (ST) 313 produces septicemia in infants in sub-Saharan Africa. Although there are known genetic and phenotypic differences between ST313 strains and gastroenteritis-associated ST19 strains, conflicting data about the in vivo virulence of ST313 strains have been reported.
Girish Ramachandran, Aruna Panda, Ellen E. Higginson, Eugene Ateh, Michael M. Lipsky, Sunil Sen, Courtney A. Matson, Jasnehta Permala-Booth, Louis J. DeTolla, Sharon M. Tennant   +9 more
openaire   +4 more sources