Results 41 to 50 of about 84,809 (258)

Multi‐Targeting Carnosic Acid Kills Drug‐Resistant Helicobacter pylori With Narrow‐Spectrum Activity

Advanced Science, EarlyView.
Carnosic acid selectively eradicates drug‐resistant Helicobacter pylori through a multi‐targeted mechanism involving urease inhibition, membrane disruption, and biofilm eradication. It exhibits no detectable resistance, potent in vivo efficacy, and minimal impact on gut microbiota, positioning it as a promising narrow‐spectrum lead compound against ...
Yuefan Bai, Hongming Huang, Xudong Hang, Shanwei Hu, Qian Tong, Jingchen Xu, Jia Jia, Hongkai Bi   +7 more
wiley   +1 more source

Virulence of invasive Salmonella Typhimurium ST313 in animal models of infection

PLOS Neglected Tropical Diseases, 2017
Salmonella Typhimurium sequence type (ST) 313 produces septicemia in infants in sub-Saharan Africa. Although there are known genetic and phenotypic differences between ST313 strains and gastroenteritis-associated ST19 strains, conflicting data about the in vivo virulence of ST313 strains have been reported.
Girish Ramachandran, Aruna Panda, Ellen E. Higginson, Eugene Ateh, Michael M. Lipsky, Sunil Sen, Courtney A. Matson, Jasnehta Permala-Booth, Louis J. DeTolla, Sharon M. Tennant   +9 more
openaire   +4 more sources

Effect of pH and Salinity on the Ability of Salmonella Serotypes to Form Biofilm

Frontiers in Microbiology, 2022
Salmonella is a major cause of food-borne infections in Europe, and the majority of human infections are caused by only a few serotypes, among them are Salmonella enterica subsp.
Sara Petrin, Sara Petrin, Marzia Mancin, Carmen Losasso, Silvia Deotto, John Elmerdahl Olsen, Lisa Barco   +6 more
doaj   +1 more source

Identification of a Nonribosomal Peptide Analog With Activity Against Multiple Gram‐Positive Bacteria via a Synthetic Bioinformatic Natural Product Discovery Approach

Advanced Science, EarlyView.
The genome of Rhodococcus erythropolis D‐1 was analyzed by bioinformatic tools to mine a novel nonribosomal peptide synthetase (NRPS) gene cluster. A nonribosomal peptide analog ZURJC5 associated with the NRPS was chemically synthesized. Through structure‐activity relationship studies, ZURJC28 was ultimately obtained and showed antibacterial activity ...
Keyi Chen, Jiayi Liang, Yujia Wu, Jianan Xu, Yi Liu, Wenguang Wang, Xinhang Jiang, Benjie Gao, Yueyue Wang, Hui Jiang   +9 more
wiley   +1 more source

Defense mechanisms of Salmonella against antibiotics: a review

Frontiers in Antibiotics
Salmonella is a foodborne pathogenic bacterium that causes salmonellosis worldwide. Also, Salmonella is considered a serious problem for food safety and public health. Several antimicrobial classes including aminoglycosides, tetracyclines, phenols, and β-
Anuradha Jeewantha Punchihewage-Don, Priyanka Nilmini Ranaweera, Salina Parveen   +2 more
doaj   +1 more source

Characterization of Salmonella isolates from municipal sewage, patients, foods, and animals in Greece using antimicrobial susceptibility testing and pulsed field gel electrophoresis [PDF]

International Journal of One Health, 2016
Aims: We aimed to compare Salmonella isolates from different sources using molecular and phenotypic methods, targeting better possibility of understanding the epidemiology of this organism in the Greek context with emphasis in municipal wastewater ...
Theofilos Papadopoulos, Antonios Zdragas, Georgia Mandilara, Georgios Vafeas, Virginia Giantzi, Evanthia Petridou, Alkiviadis Vatopoulos   +6 more
doaj   +1 more source

Targeting Lipopolysaccharide Transport Induces Membrane Lipid Remodeling and Sensitizes Acinetobacter baumannii to Colistin Treatment

Advanced Science, EarlyView.
This study identifies C4 as a lead inhibitor of the Lpt system. Notably, C4 potentiates colistin activity by disrupting LPS transport and remodeling phospholipid homeostasis, revealing a functional interplay between the Lpt and Mla systems. These findings establish a mechanistic link between Lpt inhibition and membrane lipid remodeling, positioning Lpt–
Jianya Luo, Hetianzi Zhang, Jinju Cai, Shuang Zhou, Haijie Zhang, Zhiqiang Wang, Yuan Liu   +6 more
wiley   +1 more source

Case-control investigation of invasive Salmonella disease in Malawi reveals no evidence of environmental or animal transmission of invasive strains, and supports human to human transmission.

PLoS Neglected Tropical Diseases, 2022
BackgroundInvasive Salmonella infections cause significant morbidity and mortality in Sub-Saharan Africa. However, the routes of transmission are uncertain.
Leonard Koolman, Reenesh Prakash, Yohane Diness, Chisomo Msefula, Tonney S Nyirenda, Franziska Olgemoeller, Paul Wigley, Blanca Perez-Sepulveda, Jay C D Hinton, Siân V Owen, Nicholas A Feasey, Philip M Ashton, Melita A Gordon   +12 more
doaj   +1 more source

Guidelines for Detecting the Foodborne Antibiotic‐Resistant Bacteria

AgriFood: Journal of Agricultural Products for Food, EarlyView.
ABSTRACT Foodborne antibiotic‐resistant bacteria threaten global public health and the economic. Standardized detection methods are crucial for effective prevention and control. Researchers encounter difficulties in choosing suitable techniques due to the variety of available approaches and the intricate nature of resistance mechanisms.
Yuanye Zeng, Fengxia Yang
wiley   +1 more source

Non-Typhoidal Salmonella at the Human-Food-of-Animal-Origin Interface in Australia

Animals, 2020
Non-typhoidal Salmonella is a major zoonotic pathogen that plays a significant role in foodborne human salmonellosis worldwide through the consumption of contaminated foods, particularly those of animal origin.
Hamid Reza Sodagari, Penghao Wang, Ian Robertson, Ihab Habib, Shafi Sahibzada   +4 more
doaj   +1 more source