Results 61 to 70 of about 20,124 (224)

Sirt3 Genetically Engineered Apoptotic Bodies Alleviate Skeletal Aging by Limiting Aggravated NLRP3 Inflammasome Activation of Senescent Macrophages

Advanced Science, EarlyView.
The senescence of macrophages leads to a decrease in the expression of Sirtuin3 (Sirt3), which in turn aggravates the NLRP3 inflammasome activation and IL‐1β secretion, thereby promoting the aging‐related osteoporosis. Sirt3‐enriched apoptotic bodies (ABs‐Sirt3) generated through genetic editing approaches can alleviate skeletal aging by targeting ...
Yanglin Wu, Shifeng Ling, Jiayi Mao, Hongyi Wang, Bo Wang, Zhenjia Che, Wenguo Cui, Ming Cai   +7 more
wiley   +1 more source

The Effect of Salvianolic Acid on Vascular Protection and Possible Mechanisms [PDF]

Oxidative Medicine and Cellular Longevity, 2020
Salvia miltiorrhiza (Danshen), as an important traditional Chinese medicinal plant, has been used in China for the treatment of cardiovascular diseases for hundreds of years. Salvianolic acids (salvianolic acid A and salvianolic acid B) as the most abundant water-soluble component extracted from Salvia miltiorrhiza have attracted more and more ...
Yalan Wu, Suowen Xu, Xiao Yu Tian
openaire   +2 more sources

Salvianolic acid A inhibits ferroptosis and protects against intracerebral hemorrhage. [PDF]

Sci Rep
AbstractIntracerebral hemorrhage (ICH) is a common cerebral vascular disease with high incidence, disability, and mortality. Ferroptosis is a regulated type of iron-dependent, non-apoptotic programmed cell death. There is increasing evidence that ferroptosis may lead to neuronal damage mediated by hemorrhagic stroke mediated neuronal damage ...
Shi Y, Yan D, Nan C, Sun Z, Zhuo Y, Huo H, Jin Q, Yan H, Zhao Z.   +8 more
europepmc   +4 more sources

Effects of gamma irradiation on cytotoxicity and phenolic compounds of Thymus vulgaris L. and Mentha x piperita L. [PDF]

, 2016
The aim of the present study was to evaluate the effects of gamma irradiation on cytotoxicity and phenolic compounds of Thymus vulgaris L. and Menta × piperita L. (methanolic extracts), used in traditional medicine.
Antonio, Amilcar L., Barros, Lillian, Cabo Verde, Sandra, Calhelha, Ricardo C., Ferreira, Isabel C.F.R., Pereira, Eliana, Pimenta, Andreia I., Santos-Buelga, Celestino   +7 more
core   +1 more source

Approaching Scarless Wound Healing: From Passive Anti‐Fibrotic to Proactive and Programmable Pro‐Regenerative Strategies

Advanced Science, EarlyView.
This review outlines the wound healing process and factors influencing scar formation, explores how certain animals and human fetuses achieve scarless skin or tissue regeneration, and details tissue engineering material strategies employed in scarless wound dressings.
Meimei Fu, Zhuoyi Huang, Jintao Li, Yue Li, Zhou Fang, Yiwen Jiang, Keke Wu, Jinshan Guo   +7 more
wiley   +1 more source

Cutting edge strategies for diabetic wound care: Nanotechnology, bioengineering, and beyond

BMEMat, EarlyView.
Graphical abstract illustrates the challenges in diabetic wound healing, covering pathophysiology, formulation hurdles, and emerging therapeutic strategies. It highlights the role of hyperglycemia, formulation complexities, and advanced technologies like bioprinting and AI in improving diabetic wound management. Abstract Diabetic wounds affect millions
Usama Ahmad, Wan Nurhidayah Wan Hanaffi, Anas Islam, Aimen Salman, Mohd Muazzam Khan, Faiyaz Shakeel, Qiang Cai, Xiaojun Cai, Quazi T. H. Shubhra   +8 more
wiley   +1 more source

Salvianolic acid B stimulates osteogenesis in dexamethasone-treated zebrafish larvae [PDF]

Acta Pharmacologica Sinica, 2016
Our previous studies show that salvianolic acid B (Sal B) promotes osteoblast differentiation and matrix mineralization. In this study, we evaluated the protective effects of Sal B on the osteogenesis in dexamethasone (Dex)-treated larval zebrafish, and elucidated the underlying mechanisms.At 3 d post fertilization, wild-type AB zebrafish larvae or ...
Shi-Ying, Luo, Jing-Feng, Chen, Zhi-Guo, Zhong, Xiao-Hua, Lv, Ya-Jun, Yang, Jing-Jing, Zhang, Liao, Cui   +6 more
openaire   +2 more sources

Comparison of Salvianolic Acid A Adsorption by Phenylboronic-Acid-Functionalized Montmorillonites with Different Intercalators

Molecules, 2023
Due to its success in treating cardio-cerebrovascular illnesses, salvianolic acid A (SAA) from Salvia miltiorrhiza is of major importance for effective acquisition.
Jun Qian, Jiajia Su, Weihuan Zeng, Yue Wang, Yingyuan Hu, Guoyin Kai   +5 more
doaj   +1 more source

Spearmint Extract Improves Working Memory in Men and Women with Age-Associated Memory Impairment [PDF]

, 2018
This is the final version of the article. Available from Mary Ann Liebert via the DOI in this record.OBJECTIVE: The purpose of this study was to investigate the effects of supplementation with a spearmint (Mentha spicata L.) extract, high in polyphenols ...
Ceddia, MA, Fonseca, BA, Herrlinger, KA, Lasrado, JA, Maki, KC, Nieman, KM, Sanoshy, KD, Schild, AL, Wesnes, KA   +8 more
core   +1 more source

Atomically precise metal cluster enzymes for pathological tissue regeneration

BMEMat, EarlyView.
Schematic illustration of atomically precise metal cluster enzymes (MCEs) for pathological tissue regeneration. Atomically precise MCEs can modulate biological processes, such as attenuation of inflammatory responses, eradication of bacterial pathogens, regulation of angiogenesis, and promotion of cell development.
Ziqiang Xiong, Zhifeng Shi, Mengqing Li, Jien Han, Haoyan Chen, Maofei Ran, Shaojian Zhong, Limin Ma, Chengyun Ning, Youzhun Fan, Zhenghua Tang, Peng Yu   +11 more
wiley   +1 more source