Results 161 to 170 of about 115,094,824 (204)

Preparation of salvianolic acid A by the degradation reaction of salvianolic acid B in subcritical water integrated with pH-zone-refining counter-current chromatography

Journal of Chromatography A, 2016
Salvianolic acid A is the major bioactive compound in Danshen, however, due to the chemical instability and low content in Danshen, it is difficult to extract amount of salvianolic acid A. Therefore, this study was to establish an effective strategy for obtaining adequate amount of salvianolic acid A, subcritical water extraction was used to degrade ...
Yan Cheng, Xiao Wang, Jia Li
exaly   +3 more sources

Antiplatelet and antithrombotic activities of salvianolic acid A

Thrombosis Research, 2010
Salvianolic acid A (SAA), the water-soluble phenolic acids in Salvia miltiorrhiza, has shown the most potent bioactivities, including protection against cerebral lesion, defense from oxidative damage and improvement of remembrance. In the present study, we studied the antiplatelet and antithrombotic effects of a newly synthesized SAA with different ...
Hua-Ying, Fan, Feng-Hua, Fu, Ming-Yan, Yang, Hui, Xu, Ai-Hong, Zhang, Ke, Liu   +5 more
openaire   +2 more sources

Dynamic extraction process of salvianolic acids

China Journal of Chinese Materia Medica, 2010
To optimize the dynamic extraction process of salvianolic acids.Salvianolic acids was selected as index. The effects of extraction temperature, granularity, solvent multiple, circle value and extraction time were studied on the process of dynamical extraction.
Lingqiao, Lu, Yongchuan, Zhou, Xian, Chen, Min, Zhang, Jieting, Dai   +4 more
openaire   +2 more sources

Research progress on salvianolic acids of Salvia miltiorrhiza

China Journal of Chinese Materia Medica, 2016
Salvia miltiorrhiza is one of the most common traditional Chinese medicines. It has rich resources in China. According to modern studies, phenolic acids are the main effective components in S. miltiorrhiza. These components have cardiovascular and cerebrovascular protective effect, and anti-tumor, antioxidant, anti-inflammatory, and antifibrotic ...
Wen-Yi, Liang, Wen-Jing, Chen, Guang-Hui, Yang, Dan, Zhu, Xin, Mao, Yan-Yan, Shao, Ling-Fang, Wu, Xiao-Xue, Zhang, Lan-Zhen, Zhang   +8 more
openaire   +2 more sources

A quality marker study on salvianolic acids for injection

Phytomedicine, 2018
The quality of Chinese medicine (CM) has being an active and challenging research area for CM. Prof. Chang-Xiao Liu et al first proposed the concept of quality marker (Q-Marker) for the quality evaluation and control on CM. This article describe the exploratory studies of Q-Marker in salvianolic acids for injection (SAI) based on this new concept.This ...
Wei, Li, Navaneethakrishnan, Polachi, Xiangyang, Wang, Yang, Chu, Yuan, Wang, Meng, Tian, Dekun, Li, Dazheng, Zhou, Shuiping, Zhou, Aichun, Ju, Yubo, Li, Yanjun, Zhang, Min, Chen, Luqi, Huang, Changxiao, Liu   +14 more
openaire   +2 more sources

Bioavailability of salvianolic acid B and effect on blood viscosities after oral administration of salvianolic acids in beagle dogs

Archives of Pharmacal Research, 2009
Salvianolic acid B (SalB) is an active component isolated from Chinese herbal medicine Salvia miltiorrhiza. The aim of this study was to investigate the extent of absolute oral bioavailability (F) of SalB in beagle dogs and the effect on blood viscosity after intravenous and oral administration of Salvianolic acids (SAs). A gradient elution HPLC method
Dong-Yan, Gao, Li-Mei, Han, Li-Hong, Zhang, Xiao-Ling, Fang, Jian-Xin, Wang   +4 more
openaire   +2 more sources

The total synthesis of salvianolic acid F

Tetrahedron, 1999
Abstract An expeditious synthesis of salvianolic acid F 2 is described in 10% overall yield. Tetramethyl salvianolic acid F 3 was obtained in six steps in 39% overall yield and was converted into the target molecule using boron tribromide in 26% yield.
Vincent Dalla, Philippe Cotelle
openaire   +1 more source

The asymmetric total synthesis of (+)-salvianolic acid A

Tetrahedron, 2016
Abstract An asymmetric synthesis of (+)-salvianolic acid A with cardioprotective properties, has been accomplished in a convergent manner in eight steps and 10.6% overall yield. This synthesis features an asymmetric addition of organometallics to optically pure 2,3-epoxypropionate in the presence of BF3·Et2O, Ru(III)-catalyzed directed C H ...
Yong Zheng, Wei-Bin Song, Li-Jiang Xuan
openaire   +1 more source

Transformation of Salvianolic Acid B to Salvianolic Acid A in Aqueous Solution and the In Vitro Liver Protective Effect of the Main Products

Journal of Food Science, 2014
Abstract Salvianolic acid A (Sal A) was considered to be the compound with highest activity in Salvia miltiorrhiza (danshen). Due to its low content in raw materials, many studies reported its preparation from salvianolic acid B (Sal B).
Shidong, Kan, Zhouzhou, Chen, Lei, Shao, Ji'an, Li   +3 more
openaire   +2 more sources

Cerebral Protection of Salvianolic Acid A by the Inhibition of Granulocyte Adherence

The American Journal of Chinese Medicine, 2011
Ischemic stroke is one of the most common causes of death and disability that is induced by ischemia reperfusion (IR). Granulocyte adherence has been proven to be a principal cause of IR. Salvianolic acid A (Sal A) is one of the major active components of Danshen, a Chinese herbal medicine used for the treatment of cardiovascular and cerebrovascular ...
Min, Jiang, Xiao-Ying, Wang, Wang-Yi, Zhou, Jing, Li, Jie, Wang, Li-Ping, Guo   +5 more
openaire   +2 more sources