Results 21 to 30 of about 929,762 (263)

Salvianolic acid A regulates pyroptosis of endothelial cells via directly targeting PKM2 and ameliorates diabetic atherosclerosis

Frontiers in Pharmacology, 2022
Rescuing endothelial cells from pyroptotic cell death emerges as a potential therapeutic strategy to combat diabetic atherosclerosis. Salvianolic acid A (SAA) is a major water-soluble phenolic acid in the Salvia miltiorrhiza Bunge, which has been used in
Ji Zhu, Hang Chen, Yifei Le, Jianan Guo, Zhijun Liu, Xiaobing Dou, Dezhao Lu   +6 more
semanticscholar   +1 more source

Molecular pharmacology of rosmarinic and salvianolic acids: Potential seeds for Alzheimer’s and vascular dementia drugs. [PDF]

, 2018
Both caffeic acid and 3,4-dihydroxyphenyllactic acid (danshensu) are synthesized through two distinct routs of the shikimic acid biosynthesis pathway. In many plants, especially the rosemary and sage family of Lamiaceae, these two compounds are joined ...
Bose, Chen, Gu, Haas, Habtemariam, Habtemariam, Habtemariam, Jha, Juan-Badaturugea, Moosavi, Riemens, Scarpati, Solomon Habtemariam, Tang, Wang, Zhu   +15 more
core   +5 more sources

Salvianolic Acid B: A Review of Pharmacological Effects, Safety, Combination Therapy, New Dosage Forms, and Novel Drug Delivery Routes

Pharmaceutics, 2023
Salvianolic acid B is extracted from the roots and rhizomes of Danshen (Salvia miltiorrhiza Bge., family Labiatae). It is a water-soluble, weakly acidic drug that has demonstrated antitumor and anti-inflammatory effects on various organs and tissues such
Guannan He, Guangfeng Chen, Weidong Liu, Dongxue Ye, Xuehuan Liu, Xiaodong Liang, Jing Song   +6 more
doaj   +1 more source

Simultaneous Quantification of Aspirin, Its Metabolite Salicylic Acid, and Salvianolic Acid B in Human Plasma Using UPLC-MS/MS

International Journal of Analytical Chemistry, 2021
Salvianolic acid B is the main active ingredient in salvianolate injection, which is produced by extracting danshen, the most commonly used Chinese herbal medicine for cardiovascular treatment.
Weiyi Cao, Hezhi Yao, Zhenzhen Qian, Yi Wu, Shuge Wang, Rui Li, Rui Gao   +6 more
doaj   +1 more source

Salvianolic Acid A Protects against Lipopolysaccharide-Induced Acute Lung Injury by Inhibiting Neutrophil NETosis

Oxidative Medicine and Cellular Longevity, 2022
Salvianolic acid A (SAA) is one of bioactive polyphenol extracted from a Salvia miltiorrhiza (Danshen), which was widely used to treat cardiovascular disease in traditional Chinese medicine.
Qiang Liu, Cheng-long Zhu, Hui-ru Li, Jian Xie, Yu Guo, Peng Li, Zhen-Zhen Zhao, Jia-feng Wang, X.M. Deng   +8 more
semanticscholar   +1 more source

Danshen-Chuanxiong-Honghua Ameliorates Cerebral Impairment and Improves Spatial Cognitive Deficits after Transient Focal Ischemia and Identification of Active Compounds. [PDF]

, 2017
Previously, we only apply a traditional Chinese medicine (TCM) Danshen-Chuanxiong-Honghua (DCH) for cardioprotection via anti-inflammation in rats of acute myocardial infarction by occluding coronary artery. Presently, we select not only DCH but also its
Fushun Wang, Jian Wang, Ping Ren, Tingrui Wang, Wan Zheng, Xi Huang, Xi Huang, Xianhua Zhang, Xianhua Zhang, Xinliang Ma   +9 more
core   +7 more sources

Salvianolic acid B alleviates cartilage tissue damage in rat models with osteoarthritis [PDF]

Jichu yixue yu linchuang, 2023
Objective To explore whether salvianolic acid B affects cartilage tissue damage, hypoxia-inducible factor-1 (HIF-1) and vascular endothelial growth factor (VEGF) in osteoarthritis rats. Methods A rat model of osteoarthritis was constructed, and rats were
QIAN Ligang, SUN Bo, YU Bo, CHEN Kang, MA Zheng, CHEN Taoping, WANG Yunfei
doaj   +1 more source

Rosmarinic Acid Synthase 1 Phosphorylation by SmMAPK3 Is Required for Salicylic Acid-Induced Salvianolic Acid Accumulation in Salvia miltiorrhiza Hairy Roots. [PDF]

Plant Biotechnol J
ABSTRACT Salvianolic acid is the main active component of Salvia miltiorrhiza and holds significant value in the clinical treatment of myocardial ischemia and hypoxia. Previous studies have shown that salicylic acid (SA) can significantly promote the accumulation of salvianolic acid, but its molecular mechanism remains incompletely understood.
Yin X, Liu S, Zhang Y, Yang W, Bu J, Zhang B, Dong J.   +6 more
europepmc   +2 more sources

Network Pharmacology Analyses of the Pharmacological Targets and Therapeutic Mechanisms of Salvianolic Acid A in Myocardial Infarction

Evidence-Based Complementary and Alternative Medicine, 2022
Objective Salvianolic acid A, a natural polyphenolic ingredient extracted from traditional Chinese medicine, possesses an excellent pharmacological activity against cardiovascular diseases.
Q. Huang, Chao Zhang, Shaoyong Tang, Xiaoyan Wu, Xiong Peng   +4 more
semanticscholar   +1 more source

Salvianolic Acid B in Microemulsion Formulation Provided Sufficient Hydration for Dry Skin and Ameliorated the Severity of Imiquimod-induced Psoriasis-like Dermatitis in Mice

Pharmaceutics, 2020
Psoriasis is a chronic inflammatory skin disorder with a pathogenesis involving the interleukin-23/interleukin-17 axis. Salvianolic acid B exerts several pharmacological effects, such as antioxidation, anti-inflammation, and antitumor effects.
Jiun-Wen Guo, Yu-Pin Cheng, Chih-Yi Liu, Haw-Yueh Thong, Chi-Jung Huang, Yang Lo, Chen-Yu Wu, Shiou-Hwa Jee   +7 more
doaj   +1 more source