Results 11 to 20 of about 667,703 (231)

Salvianolic Acid B: A Review of Pharmacological Effects, Safety, Combination Therapy, New Dosage Forms, and Novel Drug Delivery Routes. [PDF]

Pharmaceutics, 2023
Salvianolic acid B is extracted from the roots and rhizomes of Danshen (Salvia miltiorrhiza Bge., family Labiatae). It is a water-soluble, weakly acidic drug that has demonstrated antitumor and anti-inflammatory effects on various organs and tissues such
He G, Chen G, Liu W, Ye D, Liu X, Liang X, Song J.   +6 more
europepmc   +8 more sources

Salvianolic acid B: a promising cardioprotective agent. [PDF]

Front Immunol
Salvia miltiorrhiza Bunge [Lamiaceae; Salviae miltiorrhizae radix et rhizoma] is a core herb in traditional Chinese medicine widely used for treating cardiovascular diseases (CVD). Its key bioactive compound, salvianolic acid B (SalB), has emerged as a promising therapeutic agent for CVD.
Shao Y, Zhai L, Jiang S, Sun F, Liu X.
europepmc   +6 more sources

A Novel Mechanism of Salvianolic Acid B in Postmyocardial Infarction Cardiac Protection: PHB1-Driven Raf-ERK Pathway Activation Promotes Cardiomyocyte Mitosis. [PDF]

MedComm (2020)
SalB binds to the C‐terminal of PHB1/2 heterodimer, inducing a conformational change that enhances Raf‐ERK pathway activation via Akt‐mediated phosphorylation, thereby promoting cardiomyocyte mitosis. ABSTRACT Heart failure (HF) following myocardial infarction remains a leading cause of global morbidity and mortality, necessitating novel therapeutic ...
Cao C, Ma B, Zhang J, Yang L, Liu Z, Li H, Song J, Zhang K, Li L, Fu J, Liu J.   +10 more
europepmc   +3 more sources

Pharmacological Effects of Salvianolic Acid B Against Oxidative Damage [PDF]

Frontiers in Pharmacology, 2020
Salvianolic acid B (Sal B) is one of the main active ingredients of Salvia miltiorrhiza, with strong antioxidant effects. Recent findings have shown that Sal B has anti-inflammatory, anti-apoptotic, anti-fibrotic effects and can promote stem cell proliferation and differentiation, and has a beneficial effect on cardiovascular and cerebrovascular ...
Zhun Xiao, Wei Liu, Yongping Mu, Hua Zhang, Xiaoning Wang, Changqing Zhao, Jiamei Chen, Ping Liu   +7 more
semanticscholar   +6 more sources

Salvianolic acid B in fibrosis treatment: a comprehensive review. [PDF]

Front Pharmacol
Fibrosis is a public health issue of great concern characterized by the excessive deposition of extracellular matrix, leading to the destruction of parenchymal tissue and organ dysfunction that places a heavy burden on the global healthcare system due to its high incidence, disability, and mortality.
Liang Q, Liu X, Peng X, Luo T, Su Y, Xu X, Xie H, Gao H, Chen Z, Xie C.   +9 more
europepmc   +6 more sources

Salvianolic Acid B Inhibited LH2 Expression to Reduce Collagen Synthesis in Pulmonary Fibrosis. [PDF]

J Cell Mol Med
ABSTRACT Collagen deposition and scar formation are hallmark features of fibrotic diseases. Lysyl hydroxylase 2 (PLOD2/LH2), a key collagen‐modifying enzyme, catalyses lysine hydroxylation at telopeptide sites to promote pyridinoline cross‐link formation, thereby enhancing collagen stability and matrix stiffness.
Shao S, Rao S, Hu S, Zhang Y, Zheng P, Li C, Zhong L, Long Y, Tian X, Tang X, Luo F.   +10 more
europepmc   +2 more sources

Ultrasonic-assisted nanofiltration separation recovering salvianolic acid B from ethanol wastewater. [PDF]

Ultrason Sonochem
Highlights • Ultrasonic-assisted nanofiltration separation (UANS) was an innovative technology.• UANS was first applied to separate salvianolic acid B from organic wastewater.• UANS enables the orderly separation of phenolic acids with similar structures.
Li C, Ma Y, Xu Y, Qiu R, Shen X, Huang L, Liu A, Li M, Zheng Y, Zhi X.   +9 more
europepmc   +4 more sources

Salvianolic Acid B Alleviates Liver Injury by Regulating Lactate-Mediated Histone Lactylation in Macrophages. [PDF]

Molecules
Salvianolic acid B (Sal B) is the primary water-soluble bioactive constituent derived from the roots of Salvia miltiorrhiza Bunge. This research was designed to reveal the potential mechanism of Sal B anti-liver injury from the perspective of macrophages.
Hu S, Yang Z, Li L, Yan Q, Hu Y, Zhou F, Tan Y, Pei G.   +7 more
europepmc   +4 more sources

Preclinical and experimental evidence of salvianolic acid B in the treatment of neurological diseases. [PDF]

Front Pharmacol
BackgroundNeurological diseases such as stroke and Alzheimer’s disease pose increasing challenges to global public health. Salvianolic Acid B (SalB), a major active component of Salvia miltiorrhiza, has garnered attention due to its anti-inflammatory, antioxidant, neuroprotective, and pro-angiogenic properties in neurological disease treatment ...
Bi S, Liu S, Zhu K, Gao D, Chen L, Yu C, Liang G.   +6 more
europepmc   +5 more sources

Salvianolic acid-B improves fat graft survival by promoting proliferation and adipogenesis [PDF]

Stem Cell Research & Therapy, 2021
Background Our previous study proved that Salvia miltiorrhiza could enhance fat graft survival by promoting adipogenesis. However, the effect of salvianolic acid B (Sal-B), the most abundant and bioactive water-soluble compound in Salvia miltiorrhiza, on
Jiaming Sun, Chiakang Ho, Ya Gao, Chio-Hou Chong, Danning Zheng, Yifan Zhang, Yu Li   +6 more
openalex   +2 more sources