Results 31 to 40 of about 14,544,374 (201)

Salvianolic Acid B Prevents Arsenic Trioxide-Induced Cardiotoxicity In Vivo and Enhances Its Anticancer Activity In Vitro [PDF]

, 2013
Clinical attempts to reduce the cardiotoxicity of arsenic trioxide (ATO) without compromising its anticancer activities remain to be an unresolved issue.
Luo, Yun, Chen, Rongchang, Sun, Hong, Dong, Xi, Yao, Fan, Sun, Xiaobo, Qin, Meng, Zhang, Qiang, Wu, Ping, Wang, Min, Sun, Guibo   +10 more
core   +1 more source

Safety, tolerance, and pharmacokinetics of salvianolic acid B in healthy Chinese volunteers: A randomized, double-blind, placebo-controlled phase 1 clinical trial

Frontiers in Pharmacology, 2023
Background: Salvianolic acid B (Sal B) is one of the main active ingredients of Salvia miltiorrhiza Bunge. In China, many traditional Chinese medicines have been modified into injections for higher bioavailability and better efficacy.
Junlin Cheng, Jun Long, Jingjing Zhang, Le Han, Yunfang Hu, Jianghui Liu, Runze Qiu, Zhibin Zhu, Hongwei Fan   +8 more
doaj   +1 more source

Effects of salvianolic acid A and salvianolic acid B in renal interstitial fibrosis via PDGF-C/PDGFR-α signaling pathway

Phytomedicine, 2022
Renal interstitial fibrosis (RIF) is the main pathological feature of end-stage renal disease (ESRD) caused by various chronic kidney diseases (CKD), and is closely related to renal dysfunction and patient prognosis. Salvianolic acid A (Sal A) and salvianolic acid B (Sal B), isolated from traditional Chinese medicine Salviae miltiorrhizae, have been ...
Lan, Yao, Renjie, Zhao, Shiyang, He, Qi, Feng, Yingjin, Qiao, Pei, Wang, Jun, Li   +6 more
openaire   +2 more sources

Molecular Basis Underlying Hepatobiliary and Renal Excretion of Phenolic Acids of Salvia miltiorrhiza Roots (Danshen)

Frontiers in Pharmacology, 2022
Phenolic acids are cardiovascular constituents (originating from the Chinese medicinal herb Salvia miltiorrhiza root/Danshen) of DanHong and many other Danshen-containing injections.
Jun-Lan Lu, Jun-Lan Lu, Xue-Shan Zeng, Xue-Shan Zeng, Xin Zhou, Xin Zhou, Jun-Ling Yang, Jun-Ling Yang, Jun-Ling Yang, Ling-Ling Ren, Ling-Ling Ren, Xin-Yu Long, Xin-Yu Long, Feng-Qing Wang, Olajide E. Olaleye, Nan-Nan Tian, Nan-Nan Tian, Ya-Xuan Zhu, Ya-Xuan Zhu, Jia-Jia Dong, Wei-Wei Jia, Chuan Li, Chuan Li, Chuan Li   +23 more
doaj   +1 more source

Synthesis of SMND-309, a derivate of salvianolic acid B

Synthetic Communications, 2017
(E)-2-(6-((E)-2-carboxyvinyl)-2,3-dihydroxyphenyl)-3-(3,4-dihydroxyphenyl) acrylic acid, designated SMND-309, was synthesized starting from 2-hydroxy-3-methoxybenzaldehyde in 12 steps and with an overall yield of 44%. The synthetic key features were the conversion of aryl aldehyde into aryl acetic acid for one-carbon extended, the Perkin condensation ...
Wu, Kong, Song, Chan, Cui, Dong-Mei, Zhang, Chen   +3 more
openaire   +1 more source

Analysis on the Stability of Total Phenolic Acids and Salvianolic Acid B from by HPLC and HPLC-MS

Natural Product Communications, 2008
The stability of salvianolic acid B and total phenolic acids from Salvia miltiorrhiza in water solutions at different temperatures, in buffered aqueous solutions at different pHs and in biological fluids, including simulated gastric and intestinal fluids,
Man Xu, Jian Han, Hui-feng Li, Li Fan, Ai-hua Liu, De-an Guo   +5 more
doaj   +1 more source

Evaluation of Wound Healing Activity of Salvianolic Acid B on In Vitro Experimental Model [PDF]

International Journal of Molecular Sciences, 2021
Despite a wide range of bactericides and antiseptics, the treatment of chronic or complicated wounds is still a major challenge for modern medicine. Topical medications are the most sought-after new agents for use as treatment. The therapeutic concentration of their active substances is easy to achieve with the lowest possible burden on the patient’s ...
Urszula Szwedowicz, Anna Szewczyk, Krzysztof Gołąb, Anna Choromańska   +3 more
openaire   +3 more sources

Study on salvianolic acid B in the reduction of epidural fibrosis in laminectomy rats [PDF]

BMC Musculoskeletal Disorders, 2014
Epidural fibrosis (EF) is a common complication after laminectomy. Salvianolic acid B (Sal B) is a major bioactive component of a traditional Chinese medical agent, Salvia miltiorrhiza, which has shown anti-inflammatory, anti-fibrotic and anti-proliferative properties. The object of this study was to investigate the effect of Sal B on the prevention of
Chen, Feng, Zuo, Zhenbo, Wang, Kai, Zhang, Chengdong, Gong, Haifeng, Ye, Fagang, Ji, Aiyu, Tao, Hao   +7 more
openaire   +2 more sources

Effects of salvianolic acid B on liver fibrosis

Medicine, 2020
Abstract Background: Liver fibrosis is a pathological change existing in most chronic liver diseases, which leads to abnormal changes in liver tissue structure and affects the normal physiological function of liver. Without effectively control, liver fibrosis can develop into cirrhosis and increase the risk of liver ...
Xiaocong Ma, Meiwen Tang, Liying Lu, Jinghui Zheng, Jingjing Huang, Junhong Li, Weisheng Luo   +6 more
openaire   +2 more sources

Salvianolic acid B stimulates osteogenesis in dexamethasone-treated zebrafish larvae [PDF]

Acta Pharmacologica Sinica, 2016
Our previous studies show that salvianolic acid B (Sal B) promotes osteoblast differentiation and matrix mineralization. In this study, we evaluated the protective effects of Sal B on the osteogenesis in dexamethasone (Dex)-treated larval zebrafish, and elucidated the underlying mechanisms.At 3 d post fertilization, wild-type AB zebrafish larvae or ...
Shi-Ying, Luo, Jing-Feng, Chen, Zhi-Guo, Zhong, Xiao-Hua, Lv, Ya-Jun, Yang, Jing-Jing, Zhang, Liao, Cui   +6 more
openaire   +2 more sources