Results 21 to 30 of about 11,664 (194)

Visualizing the spatial distribution and alteration of metabolites in continuously cropped Salvia miltiorrhiza Bge using MALDI-MSI

Journal of Pharmaceutical Analysis, 2022
Salvia miltiorrhiza Bge (SMB) has long been used in traditional Chinese medicine to treat cardiovascular and cerebrovascular diseases. Growing clinical usage has led to a huge demand for artificial planting of SMB.
Chenglong Sun, Li Cui, Bingqian Zhou, Xiao Wang, Lanping Guo, Wei Liu   +5 more
doaj   +1 more source

Neuroprotective Effect of Salvianolic Acids against Cerebral Ischemia/Reperfusion Injury. [PDF]

Int J Mol Sci, 2016
This study investigated the neuroprotective effect of salvianolic acids (SA) against ischemia/reperfusion (I/R) injury, and explored whether the neuroprotection was dependent on mitochondrial connexin43 (mtCx43) via the phosphatidylinositol 3-kinase/protein kinase B (PI3K/AKT) pathway.
Hou S, Hou S, Zhao MM, Shen PP, Liu XP, Sun Y, Feng JC.   +6 more
europepmc   +4 more sources

Possible applications of salvianolic acid B against different cancers [PDF]

Exploration of Targeted Anti-tumor Therapy, 2020
Cancer is the second death causing disease worldwide after cardiovascular abnormalities. The difficulty in treating tumor cells with more precise targeted interventions and recurrence of cancer after treatment may pose great difficulty in developing sustainable therapeutic regimens.
Iram Shahzadi, Zain Ali, Sidra Bukhari, Acharan S Narula, Bushra Mirza, Reza Mohammadinejad   +5 more
openaire   +3 more sources

Pharmacological Effects of Salvianolic Acid B Against Oxidative Damage [PDF]

Frontiers in Pharmacology, 2020
Salvianolic acid B (Sal B) is one of the main active ingredients of Salvia miltiorrhiza, with strong antioxidant effects. Recent findings have shown that Sal B has anti-inflammatory, anti-apoptotic, anti-fibrotic effects and can promote stem cell proliferation and differentiation, and has a beneficial effect on cardiovascular and cerebrovascular ...
Zhun Xiao, Wei Liu, Wei Liu, Yong-ping Mu, Yong-ping Mu, Hua Zhang, Hua Zhang, Xiao-ning Wang, Xiao-ning Wang, Chang-qing Zhao, Chang-qing Zhao, Jia-mei Chen, Jia-mei Chen, Ping Liu, Ping Liu, Ping Liu   +15 more
openaire   +3 more sources

Tanshinone and salvianolic acid biosynthesis are regulated by SmMYB98 in Salvia miltiorrhiza hairy roots

Journal of Advanced Research, 2020
Salvia miltiorrhiza Bunge is an herb rich in bioactive tanshinone and salvianolic acid compounds. It is primarily used as an effective medicine for treating cardiovascular and cerebrovascular diseases.
Xiaolong Hao, Zhongqiang Pu, Gang Cao, Dawei You, Yang Zhou, Changping Deng, Min Shi, Shivraj Hariram Nile, Yao Wang, Wei Zhou, Guoyin Kai   +10 more
doaj   +1 more source

Rosmarinic Acid Synthase 1 Phosphorylation by SmMAPK3 Is Required for Salicylic Acid-Induced Salvianolic Acid Accumulation in Salvia miltiorrhiza Hairy Roots. [PDF]

Plant Biotechnol J
ABSTRACT Salvianolic acid is the main active component of Salvia miltiorrhiza and holds significant value in the clinical treatment of myocardial ischemia and hypoxia. Previous studies have shown that salicylic acid (SA) can significantly promote the accumulation of salvianolic acid, but its molecular mechanism remains incompletely understood.
Yin X, Liu S, Zhang Y, Yang W, Bu J, Zhang B, Dong J.   +6 more
europepmc   +2 more sources

Alleviatory Effects of Danshen, Salvianolic Acid A and Salvianolic Acid B on Pc12 Neuronal Cells and Drosophila Melanogaster Model of Alzheimer’s Disease [PDF]

Journal of Ethnopharmacology, 2020
Abstract Background: Alzheimer’s disease (AD) is the most common form of neurodegenerative disorder worldwide. Its pathogenesis involves the hallmark aggregation of amyloid-beta (Aβ). Of all the Aβ oligomers formed in the brain, Aβ42 has been found to be the most toxic and aggressive.
Florence Hui Ping Tan, Andrew Chung Jie Ting, Ban Guan Leow, Nazalan Najimudin, Nobumoto Watanabe, Ghows Azzam   +5 more
openaire   +2 more sources

Phenolic Profile and Biological Evaluation of Salvia ceratophylloides Ard.: A Novel Source of Rosmarinic Acid. [PDF]

Chem Biodivers
Among the various extraction techniques investigated, the methanolic ultrasound‐assisted extract (MGME‐UAE) of Micromeria graeca L exhibited the strongest bactericidal effect, selectively inhibiting Proteus mirabilis (inhibition zone 12.7 ± 0.6 mm; MIC = 6.25 mg/mL).
Bekkai D, Miceli N, Taviano MF, Coppolino C, Cacciola F, Mondello L, Trifilò P.   +6 more
europepmc   +2 more sources

Salvia miltiorrhiza in Breast Cancer Treatment: A Review of Its Phytochemistry, Derivatives, Nanoparticles, and Potential Mechanisms

Frontiers in Pharmacology, 2022
Breast cancer is one of the most deadly malignancies in women worldwide. Salvia miltiorrhiza, a perennial plant that belongs to the genus Salvia, has long been used in the management of cardiovascular and cerebrovascular diseases.
Huan Zhao, Bing Han, Xuan Li, Chengtao Sun, Yufei Zhai, Man Li, Mi Jiang, Weiping Zhang, Yi Liang, Guoyin Kai   +9 more
doaj   +1 more source

Salvianolic Acid B Prevents Arsenic Trioxide-Induced Cardiotoxicity In Vivo and Enhances Its Anticancer Activity In Vitro [PDF]

, 2013
Clinical attempts to reduce the cardiotoxicity of arsenic trioxide (ATO) without compromising its anticancer activities remain to be an unresolved issue.
Chen, Rongchang, Dong, Xi, Luo, Yun, Qin, Meng, Sun, Guibo, Sun, Hong, Sun, Xiaobo, Wang, Min, Wu, Ping, Yao, Fan, Zhang, Qiang   +10 more
core   +3 more sources