Results 151 to 160 of about 136,276,834 (195)
Naltrexone but Not Ketanserin Antagonizes the Subjective, Cardiovascular, and Neuroendocrine Effects of Salvinorin-A in Humans. [PDF]
International Journal of Neuropsychopharmacology, 2016 Salvinorin-A is a terpene found in the leaves of the plant Salvia divinorum. When administered to humans, salvinorin-A induces an intense but short-lasting modified state of awareness, sharing features with those induced by the classical serotonin-2A ...
María Rosa Ballester +2 more
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In Vitro Studies on Metabolism of Salvinorin A [PDF]
Pharmaceutical Biology, 2009 Microbial transformation of natural products is a well established model for mammalian metabolism. Salvinorin A, a diterpenoid isolated from the hallucinogenic mint Salvia divinorum Epling & Játiva-M (Lamiaceae), is a potent non-nitrogenous κ-opioid ...
Jordan Zjawiony +2 more
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Bioorganic and Medicinal Chemistry Letters, 2004
AbstractFor Abstract see ChemInform Abstract in Full Text.
Kevin Tidgewell +2 more
exaly +3 more sources
AbstractFor Abstract see ChemInform Abstract in Full Text.
Kevin Tidgewell +2 more
exaly +3 more sources
Forensic Science International, 2008
Two major salvinorins, salvinorin A (SalA) and salvinorin B (SalB), in three Salvia divinorum dried leaf products and nine of its "concentrated extract" products circulated in Japan were determined. These ingredients were extracted twice with acetonitrile and decolored with graphite carbon powder.
Kenji Kuwayama +2 more
exaly +3 more sources
Two major salvinorins, salvinorin A (SalA) and salvinorin B (SalB), in three Salvia divinorum dried leaf products and nine of its "concentrated extract" products circulated in Japan were determined. These ingredients were extracted twice with acetonitrile and decolored with graphite carbon powder.
Kenji Kuwayama +2 more
exaly +3 more sources
Total Synthesis of (−)‐Salvinorin A
Chemistry – A European Journal, 2016AbstractSalvinorin A (1) is natural hallucinogen that binds the human κ‐opioid receptor. A total synthesis has been developed that parlays the stereochemistry of l‐(+)‐tartaric acid into that of (−)‐1 via an unprecedented allylic dithiane intramolecular Diels–Alder reaction to obtain the trans‐decalin scaffold.
Nathan J. Line +4 more
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DARK Classics in Chemical Neuroscience: Salvinorin A
ACS Chemical Neuroscience, 2020Salvinorin A is the main bioactive compound in Salvia divinorum, an endemic plant with ancestral use by the inhabitants of the Mazateca mountain range (Sierra Mazateca) in Oaxaca, México. The main use of la pastora, as locally known, is in spiritual rites due to its extraordinary hallucinogenic effects.
R. Bruno Hernández-Alvarado +3 more
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The antinociceptive effect of Salvinorin A in mice
European Journal of Pharmacology, 2006Salvia divinorum is a hallucinogenic plant used by the Mazatec Indians of Mexico for traditional spiritual ceremonies. The active constituent, salvinorin A, induces profound hallucinations, however the biological mechanism for this action is not known. Affinity-binding studies suggest that the biologic activity of salvinorin A involves the kappa-opioid
Trentini F, John +2 more
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Salvia divinorum and Salvinorin A: New Pharmacologic Findings
Journal of Ethnopharmacology, 1994The diterpene salvinorin A from Salvia divinorum (Epling and Jativa-M), in doses of 200-500 micrograms produces effects which are subjectively identical to those experienced when the whole herb is ingested. Salvinorin A is effectively deactivated by the gastrointestinal system, so alternative routes of absorption must be used to maintain its activity ...
exaly +3 more sources
An immunochromatographic assay for rapid etection of salvinorin A
Journal of Immunoassay and Immunochemistry, 2017We developed an immunochromatographic assay (ICA) that enables rapid analysis of salvinorin A (Sal A) in Salvia divinorum within 10 min. The result shows that no Sal A in other samples of Lamiaceae plants was detected, but it could recognize Sal A among other substances in complex samples.
Madan Kumar, Paudel +4 more
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Intramolecular Transacetylation in Salvinorins D and E
Journal of Natural Products, 2010Extraction of fresh Salvia divinorum leaves afforded salvinorins E and D as potential biosynthesis precursors of salvinorin A, a major metabolite and a potent hallucinogen. Attempts at HPLC purification of salvinorin E (2) with acetonitrile as a solvent revealed an equilibrium with its regioisomer, salvinorin D (3), in a 3:5 ratio. The presence of both
Lukasz M, Kutrzeba +4 more
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