Results 161 to 170 of about 136,276,834 (195)

Second-generation synthesis of salvinorin A

Tetrahedron, 2009
Functionalization toward total synthesis of the hallucinogenic neoclerodane diterpenoid salvinorin A was accomplished via three double sequences: bis-enol triflate synthesis, palladium-catalyzed double carbonylation to the bis-enol triflate, and samarium diiodide-mediated double conjugate reduction. The configuration at C-12 was controlled by chelation-
Hisahiro Hagiwara, Yuhki Suka, Takashi Nojima, Takashi Hoshi, Toshio Suzuki   +4 more
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Salvinorin A: From Natural Product to Human Therapeutics

Molecular Interventions, 2006
The hallucinogenic plant Salvia divinorum (i.e., "magic mint") is a member of the Sage family that has been used for divination and shamanism by the Mazatecs. Over the past decade or so, S. divinorum has been increasingly used recreationally. The neoclerodane diterpene salvinorin A is the active component of S. divinorum, and recently, the kappa opioid
Timothy A, Vortherms, Bryan L, Roth
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Total Synthesis of the Hallucinogenic Neoclerodane Diterpenoid Salvinorin A

Organic Letters, 2008
Total synthesis of salvinorin A (1), a neoclerodane diterpenoid having the most potent hallucinogenic activity and a selective kappa-opioid agonist, was completed in 20 steps starting from enantiomerically pure hydroxy-Wieland-Miescher ketone 5.
Masato, Nozawa, Yuhki, Suka, Takashi, Hoshi, Toshio, Suzuki, Hisahiro, Hagiwara   +4 more
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Salvinorin A: Allosteric Interactions at the μ-Opioid Receptor

The Journal of Pharmacology and Experimental Therapeutics, 2007
Salvinorin A [(2S,4aR,6aR,7R,9S,10aS,10bR)-9-(acetyloxy)-2-(3-furanyl)-dodecahydro-6a,10b-dimethyl-4,10-dioxo-2h-naphtho[2,1-c]pyran-7-carboxylic acid methyl ester] is a hallucinogenic kappa-opioid receptor agonist that lacks the usual basic nitrogen atom present in other known opioid ligands.
Richard B, Rothman, Daniel L, Murphy, Heng, Xu, Jonathan A, Godin, Christina M, Dersch, John S, Partilla, Kevin, Tidgewell, Matthew, Schmidt, Thomas E, Prisinzano   +8 more
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Studies towards the total synthesis of salvinorin A

2021
This thesis was scanned from the print manuscript for digital preservation and is copyright the author. Researchers can access this thesis by asking their local university, institution or public library to make a request on their behalf. Monash staff and postgraduate students can use the link in the References field.
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Studies toward the synthesis of salvinorin A

2011
Salvinorin A [(2S,4aR,6aR,7R,9S,10aS,10bR)-9-(acetyloxy)-2-(3-furanyl)-dodecahydro-6a,10b-dimethyl-4,10-dioxo-2H-naptho[2,1-c]pyran-7-carboxylic acid methyl ester] is a trans-neoclerodane diterpene from the leaves of the hallucinogenic Mexican sage Salvia divinorum and has been identified as the principal psychoactive component in this plant of ...
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Critical Analysis of the Total Synthesis of Salvinorin A

2023
The past decade has been characterised by a resurgence in psychedelic research seeking to treat mental health issues, which claim over 700,000 lives each year. Salvinorin A, the main psychoactive substituent of Salvia divinorum, is a novel psychedelic distinct from those currently in clinical trials, presenting a unique avenue for further developments ...
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Salvinorin A: Fragment Synthesis and Modeling Studies

2009
VCU Theses and ...
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Confirmation of the NMR assignments of salvinorin A

Magnetic Resonance in Chemistry, 2007
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SALVINORIN DERIVATIVES

2020
GINDELBERGER DAVID, TALLEY JOHN J
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