Results 101 to 110 of about 2,193,169 (290)
Quantum Beam ScienceSerial crystallography is a rapidly advancing experimental technology that has seen significant development in recent years. This technique enables the continuous delivery of a series of protein crystal samples to the X-ray beam, allowing for the ...
Li Yu +8 more
doaj +1 more source
Evaluation of thyroid function in a sample of newborns through different modes of delivery
Zanco Journal of Medical Sciences, 2019 Background and objective: Congenital hypothyroidism is the most common preventable cause of mental retardation detected during early childhood. Its early diagnosis is crucial for a better outcome.
Sasan L. Hanna +2 more
doaj +1 more source
In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS
FEBS Letters, EarlyView.We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka +11 more
wiley +1 more source
Defensive Medicine and Obstetric Practices [PDF]
, 2012 Using data on physician behavior from the 1979–2005 National Hospital Discharge Surveys (NHDS), I estimate the relationship between malpractice pressure, as identified by the adoption of non-economic damage caps and related tort reforms, and certain ...
Frakes, Michael D.
core +4 more sources
Structural biology of ferritin nanocages
FEBS Letters, EarlyView.Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley +1 more source
Advanced bioanalytical techniques for pharmacokinetic studies of nanocarrier drug delivery systems
Journal of Pharmaceutical AnalysisSignificant investment in nanocarrier drug delivery systems (Nano-DDSs) has yielded only a limited number of successfully marketed nanomedicines, highlighting a low rate of clinical translation.
Xiangjun Meng, Jiayi Yao, Jingkai Gu
doaj +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Assessing the impact of amended building regulations on the operations of UK construction companies [PDF]
, 2008 The UK government continues to make regular amendments to building regulations. This is in order to keep these regulations relevant to today’s prevailing construction environment. More recently, UK building regulations have been amended to facilitate the
Dawson, Richard +2 more
core
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
A Novel Two-Stage Gas-Excitation Sampling and Sample Delivery Device: Simulation and Experiments
MachinesAsteroids are remnants of primordial material from the early stages of solar system formation, approximately 4.6 billion years ago, and they preserve invaluable records of the processes underlying planetary evolution.
Xu Yang +3 more
doaj +1 more source