Results 131 to 140 of about 13,205,348 (309)

Room temperature X-ray absorption spectroscopy of metalloenzymes with drop-on-demand sample delivery at XFELs. [PDF]

Pure Appl Chem, 2023
Bogacz I, Makita H, Simon PS, Zhang M, Doyle MD, Chatterjee R, Fransson T, Weninger C, Fuller F, Gee L, Sato T, Seaberg M, Alonso-Mori R, Bergmann U, Yachandra VK, Kern J, Yano J.   +16 more
europepmc   +1 more source

Asteroid (101955) Bennu in the laboratory: Properties of the sample collected by OSIRIS‐REx

Meteoritics & Planetary Science
On September 24, 2023, NASA's OSIRIS‐REx mission dropped a capsule to Earth containing ~120 g of pristine carbonaceous regolith from Bennu. We describe the delivery and initial allocation of this asteroid sample and introduce its bulk physical, chemical,
D. Lauretta, H. C. Connolly, Joseph E. Aebersold, C. Alexander, R. Ballouz, J. J. Barnes, H. Bates, Carina A. Bennett, Laurinne Blanche, E. H. Blumenfeld, S. Clemett, G. Cody, D. DellaGiustina, J. Dworkin, S. Eckley, D. Foustoukos, I. Franchi, D. Glavin, R. Greenwood, P. Haenecour, V. Hamilton, Dolores Hill, Takahiro Hiroi, K. Ishimaru, F. Jourdan, H. Kaplan, L. Keller, A. King, P. Koefoed, M. Kontogiannis, Loan Le, R. Macke, T. McCoy, R. E. Milliken, J. Najorka, A. Nguyen, M. Pajola, A. Polit, K. Righter, H. L. Roper, S. S. Russell, A. Ryan, S. Sandford, P. Schofield, C. Schultz, L. B. Seifert, S. Tachibana, K. Thomas-Keprta, M. S. Thompson, V. Tu, F. Tusberti, Kun Wang, T. Zega, C. Wolner   +53 more
semanticscholar   +1 more source

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

Molecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel, Izabela Kubiak, Lena Rutkowska, Żaneta Kasprzyk, Łukasz Kępczyński, Michał Bednarek, Dariusz Sobieraj, Jacek Wilkosz, Piotr Kania, Adam Jędrzejczyk, Bogdan Kałużewski, Agnieszka Gach, Tadeusz Kałużewski   +12 more
wiley   +1 more source

Study on optimization of multi-UAV nucleic acid sample delivery paths in large cities under the influence of epidemic environment. [PDF]

J Ambient Intell Humaniz Comput, 2023
Han Y, Xiang H, Cao J, Yang X, Pan N, Huang L.   +5 more
europepmc   +1 more source

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

Molecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi, Stavros Makrodimitris, Sandra van Wilpe, Iris te Paske, Vanja de Weerd, Corine M. Beaufort, Hans M. Westgeest, Jens Voortman, Maureen J. B. Aarts, Maud Rijnders, Astrid A. M. van der Veldt, Ronald de Wit, Niven Mehra, Saskia M. Wilting, Debbie G. J. Robbrecht   +14 more
wiley   +1 more source

Measuring governance and service delivery in safety net programs [PDF]

This paper develops a framework to assess organizational performance in the delivery of social safety nets. Specifically, it provides guidance to task teams and program managers for identifying indicators of governance and service quality in targeted ...
Rubio, Gloria M.
core  

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Profiling users and non-users of meal delivery services in Belgium using latent class analysis

International Journal of Behavioral Nutrition and Physical Activity
Background Ready-to-eat meal delivery services have become increasingly popular in recent years, with potential detrimental health implications as the majority of food promoted and sold is energy-dense and nutrient-poor.
Laura Helena Oostenbach, Matthew Keeble, Thomas Vanoutrive, Maartje P. Poelman, Carlijn B. M. Kamphuis, Wendy Van Lippevelde, Lukar Thornton   +6 more
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Early findings on home delivery of buprenorphine and retention in treatment for opioid use disorder

Addiction Science & Clinical Practice
Individuals with opioid use disorder face barriers accessing first-line pharmacotherapy. Home delivery interventions have been shown to improve medication adherence for other chronic diseases, but the relationship between buprenorphine home delivery and ...
Marlene C. Lira, Lauren E. Hendy, Alisha Liakas, Laura Turanchik, Clare Pritchard, Cynthia Jimes, M. Justin Coffey   +6 more
doaj   +1 more source