Results 121 to 130 of about 1,812,833 (310)

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Positive Invariance for Linear Sampled-data Systems [PDF]

, 2017
: The sampled-data framework captures conventional sampled-data systems, and it also provides an adequate representational tool for contemporary cyber-physical and smart autonomous systems.
Fontes, Fernando A C C, Sasa V Rakovic
core  

Numerically reliable identification of fast sampled systems: a novel δ-domain data-dependent orthonormal polynomial approach

, 2018
The practical utility of system identification algorithms is often limited by the reliability of their implementation in finite precision arithmetic. The aim of this paper is to develop a method for the numerically reliable identification of fast sampled
Voorhoeve, Robbert, Oomen, Tom, Voorhoeve, RJ Robbert, Oomen, TAE Tom, Robbert Voorhoeve, Tom Oomen   +5 more
core   +1 more source

Event-Triggered Sampled-Data Iterative Learning Control for Fractional-Order Cyber-Physical Systems

Fractal and Fractional
This paper investigates the output synchronization of fractional-order cyber-physical systems (FOCPSs) under communication constraints. To address limited bandwidth and high transmission costs, an event-triggered encoding-decoding sampled-data iterative ...
Jiajun Sun, Siyuan Wang, Xingyu Zhou, Xinsong Zhang, Chenghong Gu   +4 more
doaj   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Determining the intersample response of state feedback control systems using boundary value problems

Boundary Value Problems
This paper investigates intersample dynamics, a key aspect of sampled-data systems, as the controlled processes are usually physical systems. We present a novel, boundary value problem-based method to reconstruct the continuous-time response from the ...
Tamás Haba, Csaba Budai
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Sampled-data robust H∞ control for T-S fuzzy systems with time delay and uncertainties

, 2011
This paper investigates sampled-data robust H∞ control for T-S fuzzy systems with time delay and uncertainties. By introducing the free weighting matrices to deal with the integral items and converting the coupling time-varying matrix inequalities into a
Chen Peng (9826037), Qing-Long Han (9801650), E Tian (685836), Dong Yue (9847628)   +3 more
core  

Controlling aliased dynamics in motion systems? : an identification for sampled-data control approach

, 2014
Sampled-data control systems occasionally exhibit aliased resonance phenomena within the control bandwidth. The aim of this paper is to investigate the aspect of these aliased dynamics with application to a high performance industrial nano-positioning ...
Oomen, T.A.E.
core   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source