Results 231 to 240 of about 30,989,817 (290)

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

Population genomics reveals multi-scale mechanisms sustaining schistosomiasis re-emergence in a near-elimination setting. [PDF]

PLoS Negl Trop Dis
Guss HD, Francioli YZ, Grover EN, Hill A, Zou W, Wade KJ, Pike H, Gopalan SS, Yang L, Bo Z, Pollock DD, Carlton EJ, Castoe TA.   +12 more
europepmc   +1 more source

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

Molecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez, Rafael Pérez‐Díaz, Hugo Ramos‐Solano, Marina Garrido‐Casado, Vanessa C. Talayero, Miguel Vicente‐Manzanares   +5 more
wiley   +1 more source

Evolution of phenocopying in a dynamical model of developmental trajectories. [PDF]

PLoS Comput Biol
Matsushita Y, Raju A.
europepmc   +1 more source

APOBEC3 activity and DNA polymerase‐ε deficiency are associated with distinct IDH1 R132 hotspot mutations

Molecular Oncology, EarlyView.
Isocitrate dehydrogenase 1 (IDH1) mutations are highly recurrent in multiple human cancer types, including cholangiocarcinoma and glioma. IDH1 R132C is the most common IDH1 mutation in cholangiocarcinoma and likely arises from APOBEC3A‐ or APOBEC3B‐mediated deamination.
Kelly E. Butler, Bilal A. Lone, Ecem Unal, A. Rouf Banday   +3 more
wiley   +1 more source

Whose School Is Safe? Informant-Specific Validity in School Safety and Student Well-Being Assessment Across 63 Education Systems. [PDF]

Healthcare (Basel)
Sideridis G, Alghamdi M.
europepmc   +1 more source

Good to the Last Drop? Nectar Depletion by Insect Pollinators Varies Among Plant Species and Through Time. [PDF]

Ecol Evol
Gillies SH, Sponsler DB, Hackworth ZJ, McNeil DJ.   +3 more
europepmc   +1 more source

Regulation of Membrane Association and Downstream Effector Interaction of K-Ras by Its Hypervariable Region. [PDF]

Membranes (Basel)
Trifan A, Omidi Ardali H, Vermaas JV, Rudack T, Tajkhorshid E.   +4 more
europepmc   +1 more source

An efficient static sampling method for in situ measurement of rhizosphere volatile organic compounds in plant-soil systems. [PDF]

Plant Methods
Wachter AS, Barman M, van Dam NM, Tarkka M, Vetterlein D.   +4 more
europepmc   +1 more source