Results 101 to 110 of about 30,987,221 (292)
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
LQ-control of sampled continuous-time systems [PDF]
Control Systems;controle ...
Willigenburg, L.G. van, Engwerda, J.C.
core
Observer‐Based Sampled‐Data Controller in Saturated Systems via Composite Nonlinear Feedback
Engineering ReportsEmploying composite nonlinear feedback idea, an observer‐based digital controller is addressed for continuous‐time systems with input nonlinearity and disturbance. To achieve the regulation purpose, the equivalent discrete‐time equations are obtained via
Valiollah Ghaffari +3 more
doaj +1 more source
IEEE AccessThis paper is an attempt to extend the theory of positive systems to sampled-data systems. Even though where to take the initial time is unimportant in positivity of linear time-invariant systems, this is not the case for sampled-data systems because of ...
Ryosuke Shiga +2 more
doaj +1 more source
FEBS Letters, EarlyView.CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens +8 more
wiley +1 more source
Fault Diagnosis Techniques for Linear Sampled Data Systems and a Class of Nonlinear Systems [PDF]
, 2012 This thesis deals with the fault diagnosis design problem both for dynamical continuous time systems whose output signal are affected by fixed point quantization,\ud referred as sampled-data systems, and for two different applications whose dynamics are ...
Pettinari, Silvia
core
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
FEBS Letters, EarlyView.The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi +6 more
wiley +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source