Results 161 to 170 of about 3,726 (205)

Synthesis of sanguinarine, chelerythrine, and oxysanguinarine

Collection of Czechoslovak Chemical Communications, 1984
Benzo[c]phenanthridines Va and Vb have been prepared by photocyclization of amines IVa and IVb and transformed into the alkaloids sanguinarine (VIa) and chelerythrine (VIb). Oxysanguinarine (XIV) has been prepared from diazoketone XVIII.
Jan Šmidrkal
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Structural modification of sanguinarine and chelerythrine and their antibacterial activity

Natural Product Research, 2011
In this study, five derivatives of sanguinarine (1) and chelerythrine (2) were prepared, with 1 and 2 as starting materials, by reduction, oxidation and nucleophilic addition to the iminium bond C=N+. The structures of all compounds were elucidated on account of their MS, ¹H-NMR and ¹³C-NMR data.
Le Zhou
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Carcinogenic potential of sanguinarine, a phytochemical used in ‘therapeutic’ black salve and mouthwash

Mutation Research - Reviews in Mutation Research, 2017
Black salves are escharotic skin cancer therapies in clinical use since the mid 19th century. Sanguinaria canadensis, a major ingredient of black salve formulations, contains a number of bioactive phytochemicals including the alkaloid sanguinarine ...
John Pyne, Lei Liu, Graham King
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Cyanobacterial bloom mitigation by sanguinarine and its effects on aquatic microbial community structure

Environmental Pollution, 2019
Sanguinarine has strong inhibitory effects against the cyanobacterium Microcystis aeruginosa. However, previous studies were mainly limited to laboratory tests.
Jihai Shao, Zeng Qingru, Ji-Dong Gu
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Sanguinarine is an agonist of TRPA1 channel

Biochemical and Biophysical Research Communications, 2021
Sanguinarine, a benzyl isoquinoline alkaloid extracted from the root of Papaveraceae plants, shows extensive pharmacological activities including anti-microbial, anti-trypanosoma, anti-tumor, anti-platelet, anti-hypertensive effects, as well as inhibition of osteoclast formation.
Hao Chi, Xian Zhang, Xueqin Chen, Sui Fang, Qiang Ding, Zhaobing Gao   +5 more
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Sensitivity of vibrios to sanguinarine

Experientia, 1983
The sensitivity to sanguinarine of various strains belonging to 4 vibrio biotypes was investigated.Vibrio cholerae (classical) was most sensitive, andVibrio parahaemolyticus least sensitive to this alkaloid. Statistical analysis revealed significant differences between the 4 biotypes in their sensitivity to sanguinarine.
R, Nandi, M, Maiti, K, Chaudhuri, S B, Mahato, A K, Bairagi   +4 more
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Metabolism of Sanguinarine: The Facts and The Myths

Current Drug Metabolism, 2007
Sanguinarine, a quaternary benzo[c]phenanthridine alkaloid, exhibits antimicrobial and anti-inflammatory activities and for this reason it is used in dental hygiene products and feed additives. Its metabolism and disposition is the subject of constant scientific discourse. In this paper we summarize current knowledge on sanguinarine metabolism. We show
Z, Dvorák, V, Simánek
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Sanguinarine‐induced apoptosis: Generation of ROS, down‐regulation of Bcl‐2, c‐FLIP, and synergy with TRAIL

Journal of Cellular Biochemistry, 2008
Sanguinarine is a benzophenanthridine alkaloid derived from the root of Sanguinaria canadensis and other poppy-fumaria species, possessing potent antibacterial, antifungal, and anti-inflammatory activities.
Shin Kim, Taeg Kyu Kwon, Jaechan Leem
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PHOTOTOXIC AND PHOTOCHEMICAL PROPERTIES OF SANGUINARINE*

Photochemistry and Photobiology, 1992
Abstract— Sanguinarine, a commercial drug exhibiting antimicrobial and antitumor properties, was studied with respect to its basic photochemical characteristics and also with regard to its phototoxicity to mosquito larvae (Aedes atropalpus). Sanguinarine proved to be clearly phototoxic to larvae, with an LD50 of 0.096 mg/mL with near UV exposure as ...
J T, Arnason, B, Guèrin, M M, Kraml, B, Mehta, R W, Redmond, J C, Scaiano   +5 more
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Isolation from Argemone Oil of Dihydrosanguinarine and Sanguinarine : Toxicity of Sanguinarine

Nature, 1948
ARGEMONE oil has received considerable attention during recent years on account of its alleged etiological role in epidemic dropsy1-4. I pointed out5 certain anomalies of the mustard oil - argemone oil theory of epidemic dropsy and stressed the fact that a definite solution of the problem could only be arrived at by isolating the active principle from ...
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