Results 171 to 180 of about 5,249 (228)

Anticancer Plant Secondary Metabolites Evicting Linker Histone H1.2 from Chromatin Activate Type I Interferon Signaling. [PDF]

Int J Mol Sci
Vlasova O, Antonova I, Magomedova K, Osipova A, Shtompel P, Borunova A, Zabotina T, Belitsky G, Budunova I, Jordan A, Kirsanov K, Yakubovskaya M.   +11 more
europepmc   +1 more source

Hexahydrobenzo［c］phenanthridineアルカロイドの合成研究 [PDF]

ヤマモト, オキコ, 山本, 興子
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The Anticancer Effect of Sanguinarine: A Review

Current Pharmaceutical Design, 2018
In vitro and in vivo studies have revealed that Sanguinarine has antioxidant, anti-inflammatory, proapoptotic, and growth inhibitory effects on tumor cells of a variety of cancers. Previous research showed that sanguinarine induced apoptosis (cell death) and/or antiproliferative while reducing tumor cell antiangiogenic and anti-invasive properties ...
Chenxing Fu, Guiping Guan, Hongbing Wang   +2 more
exaly   +3 more sources

Sanguinarine is an agonist of TRPA1 channel

Biochemical and Biophysical Research Communications, 2021
Sanguinarine, a benzyl isoquinoline alkaloid extracted from the root of Papaveraceae plants, shows extensive pharmacological activities including anti-microbial, anti-trypanosoma, anti-tumor, anti-platelet, anti-hypertensive effects, as well as inhibition of osteoclast formation.
Hao Chi, Xian Zhang, Xueqin Chen, Sui Fang, Qiang Ding, Zhaobing Gao   +5 more
openaire   +2 more sources

Disposition of sanguinarine in the rat

Xenobiotica, 2007
Sanguinarine is an alkaloid with known antibiotic and anti-inflammatory activity and its pharmacokinetics have been studied in the rat after a single oral dose (10 mg kg(-1) body weight). Alkaloid determination in the plasma and liver was carried out by high-performance liquid chromatography-electrospray ionization mass spectrometry (HPLC/ESI-MS).
R, Vecera, B, Klejdus, P, Kosina, J, Orolin, M, Stiborová, S, Smrcek, J, Vicar, Z, Dvorák, J, Ulrichová, V, Kubán, P, Anzenbacher, V, Simánek   +11 more
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Sensitivity of vibrios to sanguinarine

Experientia, 1983
The sensitivity to sanguinarine of various strains belonging to 4 vibrio biotypes was investigated.Vibrio cholerae (classical) was most sensitive, andVibrio parahaemolyticus least sensitive to this alkaloid. Statistical analysis revealed significant differences between the 4 biotypes in their sensitivity to sanguinarine.
R, Nandi, M, Maiti, K, Chaudhuri, S B, Mahato, A K, Bairagi   +4 more
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Metabolism of Sanguinarine: The Facts and The Myths

Current Drug Metabolism, 2007
Sanguinarine, a quaternary benzo[c]phenanthridine alkaloid, exhibits antimicrobial and anti-inflammatory activities and for this reason it is used in dental hygiene products and feed additives. Its metabolism and disposition is the subject of constant scientific discourse. In this paper we summarize current knowledge on sanguinarine metabolism. We show
Z, Dvorák, V, Simánek
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Anticancer Perspectives of Sanguinarine: A Review

Current Bioactive Compounds, 2022
Background: Sanguinarine, a benzophenanthridine alkaloid extracted from Sanguinaria canadensis has been found to show an inhibitory role on proapoptotic and growth inhibitory activities in various tumor cells of experimental subjects. Objective: This review highlights and summarizes the effects of sanguinarine against cancers alongside the possible ...
Syed Amir Gilani, null Iahtisham-Ul-Haq, Muhammad Imran, Tanweer Aslam Gondal, Ishtiaque Ahmad, Aqsa Akram   +5 more
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PHOTOTOXIC AND PHOTOCHEMICAL PROPERTIES OF SANGUINARINE*

Photochemistry and Photobiology, 1992
Abstract— Sanguinarine, a commercial drug exhibiting antimicrobial and antitumor properties, was studied with respect to its basic photochemical characteristics and also with regard to its phototoxicity to mosquito larvae (Aedes atropalpus). Sanguinarine proved to be clearly phototoxic to larvae, with an LD50 of 0.096 mg/mL with near UV exposure as ...
J T, Arnason, B, Guèrin, M M, Kraml, B, Mehta, R W, Redmond, J C, Scaiano   +5 more
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Structure of Sanguinarine Base

Journal of Natural Products, 1996
The structure of sanguinarine free base was examined. The base is either bis[6-(5,6-dihydrosanguinarinyl)] ether (3) or bis[6-(5,6-dihydrosanguinarinyl)]amine (4) depending on whether Na2CO3 or NH3, respectively, is used as an alkalizing agent.
Jiří Dostál, Hana Bochořáková, Eva Táborská, Jiří Slavík, Milan Potáček, Miloš Buděšínský, Edmond de Hoffmann   +6 more
openaire   +1 more source