Results 21 to 30 of about 2,721 (182)

Influence of sanguinarine-based phytobiotic supplementation on post necrotic enteritis challenge recovery

Heliyon, 2020
In the animal production industry, plant-derived antimicrobial phytobiotics are used as an alternative to antibiotics. Here we investigated the role sanguinarine-based phytobiotic in broiler recovery from Necrotic Enteritis (NE) infection. A total of 100
Mashael R. Aljumaah, Manal M. Alkhulaifi, Riyadh S. Aljumaah, Alaeldein M. Abudabos, Abdulaziz A. Abdullatif, Gamaleldin M. Suliman, Mu'ath Q. Al-Ghadi, Dragana Stanley   +7 more
doaj   +1 more source

Sanguinarine Exhibits Antiviral Activity against Porcine Reproductive and Respiratory Syndrome Virus via Multisite Inhibition Mechanisms

Viruses, 2023
Porcine reproductive and respiratory syndrome virus (PRRSV), the etiological agent of PRRS, is prevalent worldwide, causing substantial and immense economic losses to the global swine industry.
Qiyun Ke, Kaiqi Duan, Yan Cheng, Si Xu, Shaobo Xiao, Liurong Fang   +5 more
doaj   +1 more source

Sanguinarine triggers intrinsic apoptosis to suppress colorectal cancer growth through disassociation between STRAP and MELK

BMC Cancer, 2018
Background Previous studies showed sanguinarine induced apoptosis in CRC cells but did not define the underlying mechanisms. The purpose of this work was to determine the in vivo and in vitro effects of sanguinarine on CRC tumors and to elucidate the ...
Xianling Gong, Zhihong Chen, Qinrui Han, Chunhui Chen, Linlin Jing, Yawei Liu, Liang Zhao, Xueqing Yao, Xuegang Sun   +8 more
doaj   +1 more source

Benzophenanthridine Alkaloid Chelerythrine Elicits Necroptosis of Gastric Cancer Cells via Selective Conjugation at the Redox Hyperreactive C-Terminal Sec⁴⁹⁸ Residue of Cytosolic Selenoprotein Thioredoxin Reductase

Molecules, 2023
Targeting thioredoxin reductase (TXNRD) with low-weight molecules is emerging as a high-efficacy anti-cancer strategy in chemotherapy. Sanguinarine has been reported to inhibit the activity of TXNRD1, indicating that benzophenanthridine alkaloid is a ...
Minghui Liu, Shibo Sun, Yao Meng, Ling Wang, Haowen Liu, Wuyang Shi, Qiuyu Zhang, Weiping Xu, Bingbing Sun, Jianqiang Xu   +9 more
doaj   +1 more source

Interaction of the anticancer plant alkaloid sanguinarine with bovine serum albumin. [PDF]

PLoS ONE, 2011
Interaction of the iminium and alkanolamine forms of sanguinarine with bovine serum albumin (BSA) was characterized by spectroscopic and calorimetric techniques.Formation of strong complexes of BSA with both iminium and alkanolamine forms was revealed ...
Maidul Hossain, Asma Yasmeen Khan, Gopinatha Suresh Kumar   +2 more
doaj   +1 more source

Enhancement of Macarpine Production in Eschscholzia Californica Suspension Cultures under Salicylic Acid Elicitation and Precursor Supplementation

Molecules, 2020
Macarpine is a minor benzophenanthridine alkaloid with interesting biological activities, which is produced in only a few species of the Papaveraceae family, including Eschscholzia californica.
Andrea Balažová, Júlia Urdová, Vladimír Forman, Pavel Mučaji   +3 more
doaj   +1 more source

In vitro and in silico scolicidal effect of sanguinarine on the hydatid cyst protoscoleces.

PLoS ONE, 2023
We aimed to investigate the scolicidal effects of sanguinarine on hydatid cyst protoscoleces (PSCs) in vitro and in silico. Different targets were docked into the active sites of sanguinarine. Molecular docking processes and visualization of interactions
Elham Hassanzadeh, Shahram Khademvatan, Behzad Jafari, Abbas Jafari, Elham Yousefi   +4 more
doaj   +1 more source

Sanguinarine Inhibits Mono- and Dual-Species Biofilm Formation by Candida albicans and Staphylococcus aureus and Induces Mature Hypha Transition of C. albicans

Pharmaceuticals, 2020
Previous studies have reported that sanguinarine possesses inhibitory activities against several microorganisms, but its effects on mono- and dual-species biofilms of C. albicans and S. aureus have not been fully elucidated.
Weidong Qian, Wenjing Wang, Jianing Zhang, Miao Liu, Yuting Fu, Xiang Li, Ting Wang, Yongdong Li   +7 more
doaj   +1 more source

Sanguinarine Attenuates Collagen-Induced Platelet Activation and Thrombus Formation

Biomedicines, 2021
Sanguinarine, a benzophenanthridine alkaloid, has been described to have an antiplatelet activity. However, its antithrombotic effect and the mechanism of platelet inhibition have not thoroughly been explored.
Dan Shu, Ying Zhu, Meng Lu, Ao-Di He, Jiang-Bin Chen, Ding-Song Ye, Yue Liu, Xiang-Bin Zeng, Rong Ma, Zhang-Yin Ming   +9 more
doaj   +1 more source

BCL2 promotor methylation and miR-15a/16-1 upregulation is associated with sanguinarine-induced apoptotic death in rat HSC-T6 cells

Journal of Pharmacological Sciences, 2015
Previous studies show that several pathways are involved in sanguinarine-induced apoptotic cell death, including AKT downregulation, inhibition of NF-kB activation, mediation of ROS production, downregulation of anti-apoptosis proteins XIAP and cIAP-1 ...
Da-Sheng Zhang, Yuan-Yi Li, Xiao-Jun Chen, Yu-Juan Li, Zhao-Ying Liu, Wen-Jian Xie, Zhi-Liang Sun   +6 more
doaj   +1 more source