Molecules, 2023 Targeting thioredoxin reductase (TXNRD) with low-weight molecules is emerging as a high-efficacy anti-cancer strategy in chemotherapy. Sanguinarine has been reported to inhibit the activity of TXNRD1, indicating that benzophenanthridine alkaloid is a ...
Minghui Liu +9 more
doaj +1 more source
Interaction of the anticancer plant alkaloid sanguinarine with bovine serum albumin. [PDF]
PLoS ONE, 2011 Interaction of the iminium and alkanolamine forms of sanguinarine with bovine serum albumin (BSA) was characterized by spectroscopic and calorimetric techniques.Formation of strong complexes of BSA with both iminium and alkanolamine forms was revealed ...
Maidul Hossain +2 more
doaj +1 more source
Influence of Quaternary Benzophenantridine and Protopine Alkaloids on Growth Performance, Dietary Energy, Carcass Traits, Visceral Mass, and Rumen Health in Finishing Ewes under Conditions of Severe Temperature-humidity Index. [PDF]
, 2015 Twenty Pelibuey×Katahdin ewes (35±2.3 kg) were used to determine the effects of the consumption of standardized plant extract containing a mixture of quaternary benzophenanthridine alkaloids and protopine alkaloids (QBA+PA) on growth performance, dietary
Aguilar-Hernández, A +9 more
core +2 more sources
Molecules, 2020 Macarpine is a minor benzophenanthridine alkaloid with interesting biological activities, which is produced in only a few species of the Papaveraceae family, including Eschscholzia californica.
Andrea Balažová +3 more
doaj +1 more source
In vitro and in silico scolicidal effect of sanguinarine on the hydatid cyst protoscoleces.
PLoS ONE, 2023 We aimed to investigate the scolicidal effects of sanguinarine on hydatid cyst protoscoleces (PSCs) in vitro and in silico. Different targets were docked into the active sites of sanguinarine. Molecular docking processes and visualization of interactions
Elham Hassanzadeh +4 more
doaj +1 more source
Analysis of benzo[c] phenanthridine alkaloids in Eschscholtzia californica cell culture using HPLC-DAD and HPLC-ESI-MS/MS [PDF]
, 2014 Effective HPLC-DAD and HPLC-ESI-MS/MS methods have been developed for the analysis of eight benzo[c] phenanthridine alkaloids (sanguinarine, chelirubine, macarpine, chelerythrine, dihydrosanguinarine, dihydrochelirubine, dihydromacarpine and ...
Hong Soon Rhee +4 more
core +1 more source
Structure-activity relationships of synthetic analogs of jasmonic acid and coronatine on induction of benzo[c]phenanthridine alkaloid accumulation in Eschscholzia californica cell cultures [PDF]
, 2000 A facile test system based on the accumulation of benzo[c]phenanthridine alkaloids in Eschscholzia californica cell suspension culture (an indicator of defense gene activation) has been used to analyze a series of synthetic compounds for elicitor-like ...
Dzink J.L. +5 more
core +1 more source
Validating Antimetastatic Effects of Natural Products in an Engineered Microfluidic Platform Mimicking Tumor Microenvironment [PDF]
, 2014 Development of new, antimetastatic drugs from natural products has been substantially constrained by the lack of a reliable in vitro screening system. Such a system should ideally mimic the native, three-dimensional (3D) tumor microenvironment involving ...
Ali R. +46 more
core +1 more source
Sanguinarine Attenuates Collagen-Induced Platelet Activation and Thrombus Formation
Biomedicines, 2021 Sanguinarine, a benzophenanthridine alkaloid, has been described to have an antiplatelet activity. However, its antithrombotic effect and the mechanism of platelet inhibition have not thoroughly been explored.
Dan Shu +9 more
doaj +1 more source
Journal of Pharmacological Sciences, 2015 Previous studies show that several pathways are involved in sanguinarine-induced apoptotic cell death, including AKT downregulation, inhibition of NF-kB activation, mediation of ROS production, downregulation of anti-apoptosis proteins XIAP and cIAP-1 ...
Da-Sheng Zhang +6 more
doaj +1 more source