Results 31 to 40 of about 3,726 (205)

Sanguinarine and Chelidonine Synergistically Induce Endosomal Toll-like Receptor and M1-Associated Mediators Expression

, 2020
Natural compounds represent the great capability to stimulate several cell types. Macrophage plays an important role for an effective immune response for infection and inflammation.
Nuchsupha Sunthamala, Neeranuch Sankla, Surasak Khankhum, Janchai Janpirom, Chutimun Suebsamran, Rungruedee Thiwthong, Niramon Khruaphet, Sununta Chuncher   +7 more
core   +1 more source

Enhancement of Macarpine Production in Eschscholzia Californica Suspension Cultures under Salicylic Acid Elicitation and Precursor Supplementation

Molecules, 2020
Macarpine is a minor benzophenanthridine alkaloid with interesting biological activities, which is produced in only a few species of the Papaveraceae family, including Eschscholzia californica.
Andrea Balažová, Júlia Urdová, Vladimír Forman, Pavel Mučaji   +3 more
doaj   +1 more source

Benzophenanthridine Alkaloid Chelerythrine Elicits Necroptosis of Gastric Cancer Cells via Selective Conjugation at the Redox Hyperreactive C-Terminal Sec⁴⁹⁸ Residue of Cytosolic Selenoprotein Thioredoxin Reductase

Molecules, 2023
Targeting thioredoxin reductase (TXNRD) with low-weight molecules is emerging as a high-efficacy anti-cancer strategy in chemotherapy. Sanguinarine has been reported to inhibit the activity of TXNRD1, indicating that benzophenanthridine alkaloid is a ...
Minghui Liu, Shibo Sun, Yao Meng, Ling Wang, Haowen Liu, Wuyang Shi, Qiuyu Zhang, Weiping Xu, Bingbing Sun, Jianqiang Xu   +9 more
doaj   +1 more source

Sanguinarine Inhibits Mono- and Dual-Species Biofilm Formation by Candida albicans and Staphylococcus aureus and Induces Mature Hypha Transition of C. albicans

Pharmaceuticals, 2020
Previous studies have reported that sanguinarine possesses inhibitory activities against several microorganisms, but its effects on mono- and dual-species biofilms of C. albicans and S. aureus have not been fully elucidated.
Weidong Qian, Wenjing Wang, Jianing Zhang, Miao Liu, Yuting Fu, Xiang Li, Ting Wang, Yongdong Li   +7 more
doaj   +1 more source

In vitro and in silico scolicidal effect of sanguinarine on the hydatid cyst protoscoleces.

PLoS ONE, 2023
We aimed to investigate the scolicidal effects of sanguinarine on hydatid cyst protoscoleces (PSCs) in vitro and in silico. Different targets were docked into the active sites of sanguinarine. Molecular docking processes and visualization of interactions
Elham Hassanzadeh, Shahram Khademvatan, Behzad Jafari, Abbas Jafari, Elham Yousefi   +4 more
doaj   +1 more source

BCL2 promotor methylation and miR-15a/16-1 upregulation is associated with sanguinarine-induced apoptotic death in rat HSC-T6 cells

Journal of Pharmacological Sciences, 2015
Previous studies show that several pathways are involved in sanguinarine-induced apoptotic cell death, including AKT downregulation, inhibition of NF-kB activation, mediation of ROS production, downregulation of anti-apoptosis proteins XIAP and cIAP-1 ...
Da-Sheng Zhang, Yuan-Yi Li, Xiao-Jun Chen, Yu-Juan Li, Zhao-Ying Liu, Wen-Jian Xie, Zhi-Liang Sun   +6 more
doaj   +1 more source

Disruption of nucleocytoplasmic trafficking of cyclin D1 and topoisomerase II by sanguinarine

BMC Cell Biology, 2006
Background The quaternary isoquinoline alkaloid sanguinarine is receiving increasing attention as a potential chemotherapeutic agent in the treatment of cancer.
Perkins Edward, Lamont Genelle, Holy Jon
doaj   +1 more source

Safety and efficacy of a feed additive consisting of Macleaya cordata (Willd.) R. Br. extract and leaves (Sangrovit® extra) for all poultry species (excluding laying and breeding birds) (Phytobiotics Futterzusatzstoffe GmbH)

EFSA Journal, 2023
Following a request from the European Commission, EFSA was asked to deliver a scientific opinion on the safety and efficacy of Macleaya cordata (Willd.) R. Br.
EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP), Vasileios Bampidis, Giovanna Azimonti, Maria de Lourdes Bastos, Henrik Christensen, Birgit Dusemund, Mojca Durjava, Maryline Kouba, Marta López‐Alonso, Secundino López Puente, Francesca Marcon, Baltasar Mayo, Alena Pechová, Mariana Petkova, Fernando Ramos, Yolanda Sanz, Roberto Edoardo Villa, Ruud Woutersen, Paul Brantom, Andrew Chesson, Johannes Westendorf, Paola Manini, Jordi Ortuño Casanova, Birgit Dusemund   +23 more
doaj   +1 more source

Sanguinarine inhibits membrane ruffling of Cos7 cells.

, 2013
A, Cos7 cells were treated with sanguinarine (2 µM) or wortmannin (100 nM) 15 min prior to EGF (100 ng/ml) stimulation for 5 min. After fixation with formaldehyde, cells were observed. The arrows indicate membrane ruffles.
Sayoko Ihara (290333), Yasuhisa Fukui (290334)   +1 more
core   +1 more source

Sanguinarine Protects Channel Catfish against Aeromonas hydrophila Infection by Inhibiting Aerolysin and Biofilm Formation

Pathogens, 2022
Aeromonas hydrophila is a pathogenic bacterium that can cause serious infections both in humans and aquatic animals. Antibiotics are the main approach for fighting against the pathogen.
Lushan Zhang, Liang Ma, Qiuhong Yang, Yongtao Liu, Xiaohui Ai, Jing Dong   +5 more
doaj   +1 more source