Results 51 to 60 of about 2,721 (182)
Progress in Natural Products Target Discovery Technology
MedComm, Volume 7, Issue 6, June 2026.Here, we provide a comprehensive overview of current technologies and recent advancements in therapeutic target discovery for natural products. By systematically synthesizing the principles, methodologies, and practical applications of existing experimental and computational strategies, this work provides a more actionable reference framework for ...
Qiyuan Pan +7 more
wiley +1 more source
Zhongliu Fangzhi Yanjiu, 2019 Objective To investigate the effect of sanguinarine on the invasion and migration of lung adenocarcinoma cells and its preliminary molecular mechanism. Methods MTT assay was used to observe the proliferative capacity of A549 and H1975 cells.
YANG Jia +4 more
doaj +1 more source
C4 Functionalization of the Isoquinoline Core via Oxidative Radical Substitution
ChemistrySelect, Volume 11, Issue 21, 4 June 2026.The isoquinoline ring can be easily functionalized at C‐4 through a radical‐oxidative substitution process. The resulting products can be readily cyclized under basic conditions, facilitating the construction of pyranones fused to the isoquinoline scaffold. ABSTRACTIn this work, we report a straightforward synthetic procedure that enables the selective
Oscar Coral +2 more
wiley +1 more source
Sanguinarine and Its Salts [PDF]
The Boston Medical and Surgical Journaln ...
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Advanced Science, Volume 13, Issue 21, 13 April 2026.ABSTRACT The rising incidence of chronic diseases globally has drawn widespread attention to phytochemicals, which exert targeted preventive and alleviating effect by modulating gut microbiota; thus, a potential strategy for precision nutritional interventions is offered.
Shiqi Bai +6 more
wiley +1 more source
Reducing the Sinapine Levels of Camelina sativa Seeds Through Targeted Genome Editing of REF1
Plant Biotechnology Journal, Volume 24, Issue 3, Page 1839-1865, March 2026.ABSTRACT Sinapine (O‐sinapoyl choline) is the major phenolic metabolite typically found in the oil‐rich seeds of Brassicaceae such as Camelina sativa and Brassica napus. It imparts a bitter taste to the seeds as a defence mechanism against herbivores, but it also renders them less palatable to livestock.
Amélie A. Kelly +5 more
wiley +1 more source
Fluorescence switching of sanguinarine in micellar environments
Physical Chemistry Chemical Physics, 2015 Conversion from iminium to alkanolamine form of Sanguinarine, a key member of benzylisoquinoline alkaloid family, is monitored in micellar environments by fluorescence switch.
Sagar, Satpathi +2 more
openaire +3 more sources
Advanced Science, Volume 13, Issue 10, 18 February 2026.This study reveals that XBP1s drives production of circTspan3, a circular RNA that strengthens cartilage by boosting anabolic activity and limiting cell death. Phosphorylated ANXA2 directs circTspan3 into exosomes, enabling paracrine repair. Exosomal circTspan3 expands growth‐plate cartilage and promotes in vivo regeneration, highlighting its promise ...
Yiming Pan +16 more
wiley +1 more source
Natural Products in Cancer Prevention and Therapy: Current Challenges and Future Directions
MedComm, Volume 7, Issue 2, February 2026.Natural products play a pivotal role in cancer therapy. They induce cancer cell death by reprogramming four metabolic pathways while precisely targeting the tumor microenvironment and immune cells. These compounds not only leverage novel delivery systems for innovative applications but also demonstrate unique therapeutic efficacy across clinical stages:
Ruimiao Qian +8 more
wiley +1 more source
Molecular isolation of cDNA encoding N-methylstylopine hydroxylase from greater celandine (Chelidonium majus L.) and its expression enhancement in response to salinity abiotic elicitor [PDF]
مجله بیوتکنولوژی کشاورزی, 2018 The greater celandine (Chelidonium majus L.) contains important alkaloids such as Sanguinarine. Sanguinarine is an active alkaloid with potentially antimicrobial, anti-inflammatory and anti-tumor properties that is widely found in plants of ...
Zahra Soleimani +2 more
doaj +1 more source