Results 11 to 20 of about 3,726 (205)

Sanguinarine Attenuates Collagen-Induced Platelet Activation and Thrombus Formation

Biomedicines, 2021
Sanguinarine, a benzophenanthridine alkaloid, has been described to have an antiplatelet activity. However, its antithrombotic effect and the mechanism of platelet inhibition have not thoroughly been explored.
Dan Shu, Ying Zhu, Meng Lu, Ao-Di He, Jiang-Bin Chen, Ding-Song Ye, Yue Liu, Xiang-Bin Zeng, Rong Ma, Zhang-Yin Ming   +9 more
doaj   +2 more sources

Influence of sanguinarine-based phytobiotic supplementation on post necrotic enteritis challenge recovery

Heliyon, 2020
In the animal production industry, plant-derived antimicrobial phytobiotics are used as an alternative to antibiotics. Here we investigated the role sanguinarine-based phytobiotic in broiler recovery from Necrotic Enteritis (NE) infection. A total of 100
Mashael R. Aljumaah, Manal M. Alkhulaifi, Riyadh S. Aljumaah, Alaeldein M. Abudabos, Abdulaziz A. Abdullatif, Gamaleldin M. Suliman, Mu'ath Q. Al-Ghadi, Dragana Stanley   +7 more
doaj   +2 more sources

Intein-mediated temperature control for complete biosynthesis of sanguinarine and its halogenated derivatives in yeast

Nature Communications
While sanguinarine has gained recognition for antimicrobial and antineoplastic activities, its complex conjugated structure and low abundance in plants impede broad applications.
Yuanwei Gou, Dongfang Li, Minghui Zhao, Mengxin Li, Jiaojiao Zhang, Yilian Zhou, Feng Xiao, Gaofei Liu, Haote Ding, Chenfan Sun, Cuifang Ye, Chang Dong, Jucan Gao, Di Gao, Zehua Bao, Lei Huang, Zhinan Xu, Jiazhang Lian   +17 more
doaj   +2 more sources

Sanguinarine triggers intrinsic apoptosis to suppress colorectal cancer growth through disassociation between STRAP and MELK

BMC Cancer, 2018
Background Previous studies showed sanguinarine induced apoptosis in CRC cells but did not define the underlying mechanisms. The purpose of this work was to determine the in vivo and in vitro effects of sanguinarine on CRC tumors and to elucidate the ...
Xianling Gong, Zhihong Chen, Qinrui Han, Chunhui Chen, Linlin Jing, Yawei Liu, Liang Zhao, Xueqing Yao, Xuegang Sun   +8 more
doaj   +2 more sources

Molecular Determinants of Sensitivity or Resistance of Cancer Cells Toward Sanguinarine

Frontiers in Pharmacology, 2018
For decades, natural products represented a significant source of diverse and unique bioactive lead compounds in drug discovery field. In Clinical oncology, complete tumors remission is hampered by the development of drug-resistance.
Mohamed E. M. Saeed, Nuha Mahmoud, Yoshikazu Sugimoto, Thomas Efferth, Heba Abdel-Aziz, Heba Abdel-Aziz   +5 more
doaj   +2 more sources

Sanguinarine Exhibits Antiviral Activity against Porcine Reproductive and Respiratory Syndrome Virus via Multisite Inhibition Mechanisms

Viruses, 2023
Porcine reproductive and respiratory syndrome virus (PRRSV), the etiological agent of PRRS, is prevalent worldwide, causing substantial and immense economic losses to the global swine industry.
Qiyun Ke, Kaiqi Duan, Yan Cheng, Si Xu, Shaobo Xiao, Liurong Fang   +5 more
doaj   +2 more sources

Interaction of the anticancer plant alkaloid sanguinarine with bovine serum albumin. [PDF]

PLoS ONE, 2011
Interaction of the iminium and alkanolamine forms of sanguinarine with bovine serum albumin (BSA) was characterized by spectroscopic and calorimetric techniques.Formation of strong complexes of BSA with both iminium and alkanolamine forms was revealed ...
Maidul Hossain, Asma Yasmeen Khan, Gopinatha Suresh Kumar   +2 more
doaj   +2 more sources

Data set of differentially expressed microRNAs in sanguinarine-treated Caenorhabditis elegans and its F3 progeny

Data in Brief, 2018
This article presents small RNA sequencing data of Caenorhabditis elegans consist of P0 control worms (untreated), P0 worms treated with a plant alkaloid, sanguinarine, and its F3 offspring.
Yit-Lai Chow, Fumihiko Sato
doaj   +2 more sources

The Ca²⁺-CAMTA6-PP2C49-HKT1;1 signaling axis modulates ion homeostasis during Arabidopsis seed germination under salt stress. [PDF]

Plant J
SUMMARY Soil salinization severely constrains seedling establishment by disrupting cellular Na+/K+ homeostasis. Calcium (Ca2+) signaling contributes to the re‐establishment of ion balance during early growth, yet the mechanisms linking Ca2+ perception to ion transport regulation remain unclear.
Kiere Y, Chandran AEJ, Sobol G, Cremer O, Azoulay-Portal S, Wexler Y, Shkolnik D.   +6 more
europepmc   +2 more sources

Safety of a feed additive consisting of <i>Macleaya cordata</i> (Willd.) R. Br. extract and leaves (Sangrovit® Extra) for suckling and weaned piglets and other growing Suidae (Phytobiotics Futterzusatzstoffe GmbH). [PDF]

EFSA J
Abstract Following a request from the European Commission, EFSA was asked to deliver a scientific opinion on the safety of a feed additive consisting of Macleaya cordata (Willd.) R. Br. extract and leaves (Sangrovit® Extra) as a zootechnical feed additive for suckling and weaned piglets and other growing Suidae.
EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP), Villa RE, Azimonti G, Bonos E, Christensen H, Durjava M, Dusemund B, Gehring R, Glandorf B, Kouba M, López-Alonso M, Marcon F, Martelli G, Nebbia C, Pechová A, Prieto-Maradona M, Theodoridou K, Bastos ML, Benfenati E, Brantom P, Chesson A, Schlatter J, Westendorf J, Manini P, Dusemund B.   +24 more
europepmc   +2 more sources