Results 81 to 90 of about 3,726 (205)

Antiproliferative and antiangiogenic effects of the benzophenanthridine alkaloid sanguinarine in melanoma [PDF]

, 2009
This study was aimed at evaluating the potential application of benzophenanthridine alkaloids, sanguinarine and cheleritrine, in the therapy of melanoma cancer.
Scambia, Giovanni, Prisco, Maria Grazia, De Stefano, Ilaria, Gian Franco Zannoni, Cristiano Ferlini, Maria Grazia Prisco, Ferlini, Cristiano, Mosca, Marco, Marco Mosca, Travaglia, Daniele, Giovanni Scambia, Ilaria De Stefano, Daniele Travaglia, Daniela Gallo, Gallo, Daniela, Raspaglio, Giuseppina, Zannoni, Gian Franco, Giuseppina Raspaglio   +17 more
core   +1 more source

Safety and efficacy of a feed additive consisting of Macleaya cordata (Willd.) R. Br. extract and leaves (Sangrovit® Extra) for suckling and weaned piglets and other growing Suidae (Phytobiotics Futterzusatzstoffe GmbH)

EFSA Journal
Following a request from the European Commission, EFSA was asked to deliver a scientific opinion on the safety and efficacy of Macleaya cordata (Willd.) R. Br.
EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP), Vasileios Bampidis, Giovanna Azimonti, Maria de Lourdes Bastos, Henrik Christensen, Mojca Durjava, Birgit Dusemund, Maryline Kouba, Marta López‐Alonso, Secundino López Puente, Francesca Marcon, Baltasar Mayo, Alena Pechová, Mariana Petkova, Fernando Ramos, Roberto Edoardo Villa, Ruud Woutersen, Paul Brantom, Andrew Chesson, Noël Dierick, Giovanna Martelli, Josef Schlatter, Johannes Westendorf, Jordi Ortuño Casanova, Daniel Pagés Plaza, Paola Manini   +25 more
doaj   +1 more source

Phytochemical Analysis and Antimicrobial Efficacy of against Extensively Drug-Resistant

Natural Product Communications, 2018
The antibiotic resistant threat is continuing to grow, due in part to the overuse of antibiotics in livestock feed. Many nations in Europe have banned the use of antibiotics in feed, leading to higher rates of infection in livestock animals and reduced ...
Manead Khin, Alan M. Jones, Nadja B. Cech, Lindsay K. Caesar   +3 more
doaj   +1 more source

The Interference of Selected Cytotoxic Alkaloids with the Cytoskeleton: An Insight into Their Modes of Action

Molecules, 2016
Alkaloids, the largest group among the nitrogen-containing secondary metabolites of plants, usually interact with several molecular targets. In this study, we provide evidence that six cytotoxic alkaloids (sanguinarine, chelerythrine, chelidonine ...
Xiaojuan Wang, Mine Tanaka, Sonja Krstin, Herbenya Silva Peixoto, Michael Wink   +4 more
doaj   +1 more source

PRODUCTION OF SANGUINARINE BY SUSPENSION-CULTURE OF PAPAVER-SOMNIFERUM IN BIOREACTORS

, 1992
A cell line of Papaver somniferum was cultivated in various sizes of bioreactors (up to 300 l) to investigate both large scale suspension culture and sanguinarine production.
EPPSTEIN, D, FRIESEN, L, GILES, KL, PARK, JM, ROEWER, I, NOVAKOVSKI, D, SONGSTAD, DD, YOON, SY   +7 more
core   +1 more source

Sanguinarine suppresses migration and metastasis in colorectal carcinoma associated with the inversion of EMT through the Wnt/β‐catenin signaling

Clinical and Translational Medicine, 2020
Background Unresectable lung or liver organ metastases of colorectal carcinoma (CRC) remain a major obstacle in clinical therapeutics. Epithelial to mesenchymal transition (EMT), a major cause of highly frequent metastasis in tumor, can be promoted by ...
Man Zhu, Zhengyan Gong, Qing Wu, Xianpeng Shi, Qi Su, Yanmin Zhang   +5 more
doaj   +1 more source

Cellular and molecular parameters of sanguinarine induced bimodal cell death

, 2002
Sanguinarine is a potential anti-cancer drug belonging to the benzophenanthridine alkaloids. K562 erythroleukemia cells treated with sanguinarine at concentrations of 1.5 (ig/ml for 2 hours displayed the morphology of apoptosis or programmed cell death ...
Weerasinghe, Priya
core  

The benzophenanthridine alkaloid sanguinarine perturbs microtubule assembly dynamics through tubulin binding: a possible mechanism for its antiproliferative activity [PDF]

, 2006
Sanguinarine has been shown to inhibit proliferation of several types of human cancer cell including multidrug-resistant cells, whereas it has minimal cytotoxicity against normal cells such as neutrophils and keratinocytes.
Panda, Dulal, Lopus, Manu
core   +1 more source

2-(Substituted phenyl)-3,4-dihydroisoquinolin-2-iums as Novel Antifungal Lead Compounds: Biological Evaluation and Structure-Activity Relationships

Molecules, 2013
The title compounds are a class of structurally simple analogues of quaternary benzo[c]phenanthridine alkaloids (QBAs). In order to develop novel QBA-like antifungal drugs, in this study, 24 of the title compounds with various substituents on the N ...
Xin-Juan Yang, Fang Miao, Li-Fei Zhu, Cen Zhang, Rui Yang, Zhe Hou, Le Zhou   +6 more
doaj   +1 more source

Long Non-Coding RNA LINC01430 Mediates Inhibitory Effect of Sanguinarine on Non-Small Cell Lung Cancer

Zhongliu Fangzhi Yanjiu
ObjectiveTo investigate the regulatory role and underlying mechanism of the long non-coding RNA (LncRNA) LINC01430 in the inhibitory effect of sanguinarine on non-small cell lung cancer (NSCLC).
Ping XU, Zhongqi WANG, Haibin DENG, Jia YANG   +3 more
doaj   +1 more source