Results 91 to 100 of about 3,726 (205)

Antiplatelet Effect of Sanguinarine Is Correlated to Calcium Mobilization , Thromboxane and Camp Production

, 2008
Sanguinarine is a plant alkaloid present in the root of Sanguinaria canadensis and Poppyfumaria species. Sanguinarine has been used as an antiseptic mouth rinse and a toothpaste additive to reduce dental plaque and gingival inflammation.
JENG, JIIANG-HUEI;WU, HUI-LIN;LIN, BOR-RU;LAN, WAN-HONG;CHANG, HSIAO-HUA;HO, YUAN-SOON;LEE, PO-HSUEN;WANG, YING-JAN;WANG, JUO-SONG;CHEN, YI-JANE;CHANG, MEI-CHI, 鄭景暉;吳慧琳;林伯儒;藍萬烘;張曉華;何元順;李柏勳;王應然;王若松;陳羿貞;張美姬   +1 more
core  

Sanguinarine Induces Necroptosis of HCC by Targeting PKM2 Mediated Energy Metabolism

Backgrounds: Abnormal metabolism is the hallmark of hepatocellular carcinoma. Targeting energy metabolism has become the major focus of cancer therapy.
Nan Wang, Yuqing Zhou, Yuejuan Zheng, Rui Kong, Xiaoyan Guo, Chunli Zhou, Dongyan Wang, Rong Wan, Yihai Shi, Jie Lu   +9 more
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Sanguinarine suppresses basal-like breast cancer growth through dihydrofolate reductase inhibition

, 2014
Basal-like breast cancer (BLBC) remains a great challenge because of its clinically aggressive nature and lack of effective targeted therapy. We analyzed the potential anti-neoplastic effects of sanguinarine, a natural benzophenanthridine alkaloid ...
Pietrella, L, MARCHINI, Cristina, AMICI, Augusto, Zabaleta, Me, GAMBINI, VALENTINA, Lucia Pietrella, GARULLI, Chiara, Zabaleta, M. E., Mara Giangrossi, KALOGRIS, Cristina, Chiara Garulli, TILIO, MARTINA, BARTOLACCI, Caterina, Augusto Amici, Tilio, M, Giangrossi, M, GIANGROSSI, Mara, Pucciarelli, S, Cristina Marchini, Belletti, B, Marchini, C, Cristina Kalogris, Manuela Iezzi, Valentina Gambini, ANDREANI, CRISTINA, Maria Elexpuru Zabaleta, IEZZI, MANUELA, PUCCIARELLI, Stefania, Barbara Belletti, Stefania Pucciarelli, Andreani, C, Lucci, C, Cristiano Lucci, Caterina Bartolacci, Lucci, C., Martina Tilio, Cristina Andreani, Gambini, V, Bartolacci, C, Garulli, C, Amici, A.5., Kalogris, C, PIETRELLA, LUCIA, Belletti, B., Iezzi, M.   +44 more
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Sanguinarine-dependent induction of apoptosis in primary effusion lymphoma cells

, 2007
Primary effusion lymphoma (PEL) is an incurable, aggressive B-cell malignancy that develops rapid resistance to conventional chemotherapy. In efforts to identify novel approaches to block proliferation of PEL cells, we found that sanguinarine, a natural ...
Al-Hussein, Khalid, C. Platanias, Leonidas, A. Al-Jomah, Naif, Manogaran, Pulicat, Abubaker, Jehad, K. Siraj, Abdul, S. Al-Kuraya, Khawla, Shahab Uddin,, Hussain, Azhar   +8 more
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Antitumor effects of the benzophenanthridine alkaloid sanguinarine in a rat syngeneic model of colorectal cancer

, 2011
To evaluate the in-vivo preclinical antitumor activity of sanguinarine in a rat syngeneic model of colorectal cancer. The effects of sanguinarine on DHD/K12/TRb colorectal adenocarcinoma cells were first evaluated in vitro by means of H-thymidine ...
Moroni, Gabriella, Pica, F, Moroni, N, Palmieri, G, Gaziano, Roberta, Balestrieri, Emanuela, Garaci, Enrico, Maurizio Mattei, Paola Sinibaldi-Vallebona, Roberta Gaziano, Noemi Moroni, Serafino, A, Moroni, Noemi, Garaci, E, Annalucia Serafino, Balestrieri, E, Roberta Sorrentino, Sorrentino, Roberta, Gabriella Moroni, Graziana Palmieri, Sorrentino, R, Emanuela Balestrieri, Mattei, M, Enrico Garaci, Gaziano, R, Francesca Pica, Palmieri, Graziana, Sinibaldi-Vallebona, Paola, Pica, Francesca, Mattei, Maurizio, Sinibaldi Vallebona, P, Serafino, Annalucia, Moroni, G   +32 more
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Effects of Berberine, Chelerythrine, and Sanguinarine on Proliferation in Four Human Immortalized Cell Lines [PDF]

, 2012
Bloodroot (Sanguinaria canadensis L., Papaveraceae) is a plant rich in benzophenanchridine (isoquinoline) alkaloids such as sanguinarine and chelerychrine.
Senchina, David S., Shah, Nisarg B., Busch, Marc G.   +2 more
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A STUDY ON SANGUINARINE AS AN ANTILEUKEMIC AGENT- INVOLVEMENT OF REACTIVE OXYGEN SPECIES-CERAMIDE-AKT APOPTOTIC SIGNALING PATHWAY [PDF]

, 2016
Dysregulation of apoptosis is a prime hallmark of leukemia. Therefore, drugs which restore the sensitivity of leukemic cells to apoptotic stimuli are promising candidates in the treatment of leukemia.
Cheratta, Anees Rahman
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In Vitro Study of Antitumor and Antimicrobial Activity of a Preparation of Pegylated Liposomes with Sanguinarine

Антибиотики и Химиотерапия, 2020
Sanguinarin is a plant alkaloid with a wide spectrum of biological activity. The effectiveness of sanguinarin can be increased by its integration into liposomal nanoparticles.
S. V. Lutsenko, T. I. Gromovykh, V. V. Kashirin, V. N. Kuryakov, A. A. Baranova, V. S. Sadykova, N. B. Feldman   +6 more
doaj  

Molecular basis of recognition of quadruplexes human telomere and c-myc promoter by the putative anticancer agent sanguinarine

, 2013
Background: Interaction of putative anticancer agent sanguinarine with two quadruplex forming sequences, human telomeric DNA (H24) and NHE III1 upstream of the P1 promoter of c-myc (Pu27), has been studied to understand the structural basis of the ...
Chowdhury, Shantanu, Dasguptaa, Dipak, Ghosh, Saptaparni, Pradhan, Suman Kalyan, Kar, Anirban   +4 more
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ROS generation by sanguinarine in the bladder cancer cells.

, 2013
(A) The cells were incubated with 1.5 µM sanguinarine for the indicated times, or they were pretreated with 10 mM NAC for 1 h and further treated with 1.5 µM sanguinarine for the indicated times. They were then stained with DCFH-DA.
Cheol Park (358509), Min Ho Han (586092), Cheng-Yun Jin (586093), Gi-Young Kim (137710), Yung Hyun Choi (132605), Sung-Kwon Moon (137717), Wun-Jae Kim (81624), Young-Chae Chang (436164)   +7 more
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