Emerging Topical and Systemic JAK Inhibitors in Dermatology [PDF]
, 2019 Accumulating data on cellular and molecular pathways help to develop novel therapeutic strategies in skin inflammation and autoimmunity. Examples are psoriasis and atopic dermatitis, two clinically and immunologically well-defined disorders.
Ghoreschi, Kamran +2 more
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A Case of SAPHO Syndrome Complicated by Uveitis with Good Response to Both TNF Inhibitor and JAKinib
Case Reports in Rheumatology, 2023 Introduction SAPHO (synovitis, acne, pustulosis, hyperostosis, and osteitis) syndrome is a rare autoinflammatory condition describing the constellation of inflammatory skin, bone, and joint manifestations which result in diagnostic difficulty and ...
Ritasman Baisya +3 more
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Propionibacterium acnes, Coagulase-Negative Staphylococcus, and the "Biofilm-like" Intervertebral Disc [PDF]
, 2016 STUDY DESIGN: Patients scheduled for spinal surgery were screened prospectively for a microbial presence associated with intervertebral disc specimens. Inclusion was limited to patients requiring surgery for any of five conditions: study patients with
Coscia, Michael F. +2 more
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SAPHO syndrome with pathological fractures of vertebral bodies: a case report
BMC Musculoskeletal Disorders, 2019 Background It’s difficult to diagnose and treat synovitis-acne-pustulosis-hyperostosis-osteomyelitis (SAPHO) syndrome due to its rare and unknown pathogenesis. There is no effective treatment for SAPHO syndrome and the consequences of empirical treatment
Yalong Li +4 more
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2015 Annual Meeting of the Medical Dermatology Society [PDF]
, 1871 Von J ...
Jettinger, J.
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Frontiers in Medicine, 2021 A 69-year-old female with recurrent stage IV squamous cell lung carcinoma and metastatic abdominal lymph node but not bone metastases was being treated with pembrolizumab. Four months after starting the recurrent treatment, the tumour reduced in size but
Yuko Kubo +4 more
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Anakinra and related drugs targeting interleukin-1 in the treatment of cryopyrin-associated periodic syndromes [PDF]
, 2014 Anakinra is an interleukin (IL) receptor antagonist that works by blocking the biological activity of IL-1 by competitively inhibiting binding of IL-1 to the type 1 interleukin receptor.
Bachove, Inessa, Chang, Christopher
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Journal of Dermatological Treatment, 2023 Synovitis, acne, pustulosis, hyperostosis, and osteitis (SAPHO) syndrome is a rare autoinflammatorydisorder without standardized therapy. IL-17 inhibitors have been effective in individual cases. However, some patients with SAPHO may develop psoriasiform
Li Luan, Chengzhi Lv
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Synovitis, acne, pustulosis, hyperostosis, and osteitis syndrome: review and update
Therapeutic Advances in Musculoskeletal Disease, 2020 Synovitis, acne, pustulosis, hyperostosis, and osteitis (SAPHO) syndrome is a spectrum of heterogeneous diseases characterized by osteoarticular and dermatological manifestations.
Shuang Liu +3 more
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Severe Back Pain in a Young Patient with Pyoderma Gangrenosum and Crohn’s Disease Controlled with Anti-tumor Necrosis Factor Therapy: Sterile Osteomyelitis [PDF]
, 2014 INTRODUCTION: Inflammatory bowel disease has been associated with a number of cutaneous and systemic neutrophilic disorders, including pyoderma gangrenosum. In 1972, the term chronic multi-focal recurrent osteomyelitis was given to a sterile neutrophilic
Calum Lyon +2 more
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