Results 31 to 40 of about 64,127 (265)

Cytotoxic triterpenoid saponins from Clematis tangutica

, 2016
Eight previously undescribed oleanane-type triterpenoid saponins, clematangoticosides A-H, together with eight known saponins, were isolated from the whole plants of Clematis tangutica (Maxim.) Korsh.
Xia, B, Gu, YC, Chen, L, Fang, DM, Chen, XZ, Da-Wa, ZM, Ding, LS, Zhou, Y, Zhou, Y (reprint author), Chinese Acad Sci, Key Lab Mt Ecol Restorat & Bioresource Utilizat, Chengdu Inst Biol, Chengdu 610041, Peoples R China., Xu, HX, Zhao, M, Guo, DL   +11 more
core   +1 more source

Chemical composition and cellulase-assisted extraction of total saponins from Gomphrena celosioides Mart.

, 2020
The major purpose of the present study was to determine the chemical composition of dried Gomphrena celosioides Mart., including crude protein, lipid, total sugar, reducing sugar, ash, crude fiber, moisture, crude pectin, and total saponins in particular.
Yen, N.T.H., Le Quoc, Nguyen Yen, Quoc, L.P.T.   +3 more
core   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Potential Use of Agave Genus in Neuroinflammation Management

Plants, 2022
Agavaceae contains about 480 species, commonly used in the production of alcoholic beverages such as tequila and mezcal, making it a resource of economic and cultural importance.
Maribel Herrera-Ruiz, Enrique Jiménez-Ferrer, Manasés González-Cortazar, Alejandro Zamilpa, Alexandre Cardoso-Taketa, Martha Lucía Arenas-Ocampo, Antonio Ruperto Jiménez-Aparicio, Nayeli Monterrosas-Brisson   +7 more
doaj   +1 more source

Hydrophilic interaction chromatography for selective separation of isomeric saponins

, 2014
A method based on a Click Xlon zwitterionic stationary phase was developed to separate isomeric saponins efficiently in hydrophilic interaction chromatography (HILIC) mode using methanol as a weak eluent. The retention times of a set of isomeric saponins,
Liang, Xinmiao, Guo, Xiujie, Zhang, Xiuli, Guo, Zhimou, Shen, Aijin, Liu, Yanfang, Jin, Gaowa, 张秀莉   +7 more
core   +1 more source

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

Regulation of anti-tumour effects of Paris polyphylla saponins via ROS: molecular mechanisms and therapeutic potentials

Frontiers in Pharmacology
Reactive oxygen species (ROS) exhibit a dual regulatory role in cancer biology. While moderate ROS levels promote tumorigenesis via DNA mutagenesis, excessive ROS accumulation induces cancer cell death through oxidative stress. Therefore, ROS homeostasis
Jia Liu, Yongping Mu, Yongping Mu, Ke Qi, Jiayi Li, Yang Hu   +5 more
doaj   +1 more source

Yield and Nutritional Characterization of Thirteen Quinoa (Chenopodium quinoa Willd.) Varieties Grown in North-West Europe—Part I

Plants, 2021
The cultivation of quinoa has gained increasing interest in Europe. Different European varieties exist, but more research is required to understand the individual variety characteristics for end-use applications.
Phara De Bock, Filip Van Bockstaele, Hilde Muylle, Paul Quataert, Pieter Vermeir, Mia Eeckhout, Gerda Cnops   +6 more
doaj   +1 more source

Endogenous resistance to insect pests in alfalfa: engineering for enhanced resistance [PDF]

, 1997
Alfalfa (Medicago sativa) is a valuable forage crop grown throughout the World. While the crop is resistant to attack by many insect pests, it is subject to potentially severe losses through the action of several specific pests, which are adapted to ...
Mazahery-Laghab, Hojjatollah, Mazahery-Laghab, H.   +1 more
core  

PARP inhibitors induce a senescence phenotype in non‐small cell lung carcinoma cell lines

FEBS Open Bio, EarlyView.
Talazoparib is the most potent inducer of senescence among different PARP1 inhibitors in human NSCLC cells. In the absence of PARP, no senescence phenotype was observed, demonstrating that PARP1 is necessary for the induction of senescence by this inhibitor.
Camille Huart, Manon Van den Abbeel, Christoph Schifflers, Karim Bouhjar, Andrea Scarmelotto, Alexis Khelfi, Anne‐Catherine Wera, Carine Michiels   +7 more
wiley   +1 more source