Results 51 to 60 of about 64,127 (265)

Poecillastrosides, Steroidal Saponins from the Mediterranean Deep-Sea Sponge Poecillastra compressa (Bowerbank, 1866)

Marine Drugs, 2017
The first chemical investigation of the Mediterranean deep-sea sponge Poecillastra compressa (Bowerbank, 1866) led to the identification of seven new steroidal saponins named poecillastrosides A–G (1–7).
Kevin Calabro, Elaheh Lotfi Kalahroodi, Daniel Rodrigues, Caridad Díaz, Mercedes de la Cruz, Bastien Cautain, Rémi Laville, Fernando Reyes, Thierry Pérez, Bassam Soussi, Olivier P. Thomas   +10 more
doaj   +1 more source

Fine‐Tuned Regulation of mRNA Translation and Transport by STAU2 Condensate Facilitates Neuronal Development and Plasticity

Advanced Science, EarlyView.
STAU2 undergoes phase separation to form dynamic condensates that package target mRNAs and deliver them to the distal ends of growing neuronal dendrites. STAU2 condensates stabilize embedded mRNAs and repress their translation. Synaptic activity bidirectionally remodels STAU2 condensates, coordinating local translation of STAU2‐associated mRNAs ...
Shijing Huang, Yuanyuan Chu, Ruiqian Zhao, Siyu Li, Yu Feng, Hongdan Zheng, Yunli Xie, Tong Wang, Wenyu Wen   +8 more
wiley   +1 more source

Antitumor activity of Bulgarian herb Tribulus terrestris L. on human breast cancer cells [PDF]

Journal of BioScience and Biotechnology, 2013
Medicinal plants have been intensively studied as a source of antitumor compounds. Due to the beneficial climate conditions Bulgarian herbs have high pharmacological potential.
Svetla Angelova, Zlatina Gospodinova, Maria Krasteva, Georgi Antov, Valentin Lozanov, Tsanko Markov, Stefan Bozhanov, Elena Georgieva, Vanio Mitev   +8 more
doaj  

Saponins as cytotoxic agents : an update (2010-2018) : part I-steroidal saponins [PDF]

, 2020
Steroidal saponins are a group of glycosides widely distributed among monocotyledonous families. They exert a wide spectrum of biological effects including cytotoxic and antitumor properties which are the most studied.
Wróbel-Biedrawa, Dagmara, Podolak, Irma, Galanty, Agnieszka, Makowska-Wąs, Justyna, Grabowska, Karolina, Sobolewska, Danuta   +5 more
core   +1 more source

Engineered Carbon Dots from a Traditional Herb Pair Orchestrate Concurrent Antioxidant and AP‐1‐Mediated Inflammation to Attenuate Renal Ischemia‐Reperfusion Injury

Advanced Science, EarlyView.
This study integrates two complementary traditional Chinese medicine components as precursors to synthesize bioactive AM‐AS@CDs. Compared with single‐component CDs, these dual‐component CDs exhibit enhanced antioxidant capacity and superior renoprotective effects.
Bixiao Liu, Fuying Zhu, Zhuqing Wang, Jiawen Chen, Xiaomiao Cui, Congzhong Yang, Yao Peng, Dengyuan Feng, Li Lu, Hui Wei, Xiaozhi Zhao   +10 more
wiley   +1 more source

Cadmium and Copper Stress Responses in Soapbark Tree (Quillaja saponaria): Effects on Growth, Metal Accumulation, Saponin Concentration, and Gene Expression

Plants
Heavy metals such as Cu and Cd are important pollutants. Quillay (Quillaja saponaria) is a tree species endemic to Chile that is of worldwide commercial interest due to its saponins. It can grow on contaminated sites.
Javiera Lazo, Jaime Tapia, Fernando P. Guerra   +2 more
doaj   +1 more source

Sulfated Cyclocarya Paliurus Polysaccharide Sorchestrates the Gut Microbiome to Mobilize a Host‐Derived 12‐HEPE Against Ulcerative Colitis

Advanced Science, EarlyView.
A sulfated polysaccharide (SCP) from Cyclocarya paliurus alleviates ulcerative colitis by reshaping the gut microbiome. This remodeled microbiota orchestrates the upregulation of the host‐derived lipid 12‐HEPE, which directly inhibits the TLR4/NF‐κB pathway to suppress inflammation.
Xianxiang Chen, Mingyue Shen, Rui Zhang, Zhibing Huang, Hui Niu, Qiang Yu, Yi Chen, Xiangwen Pan, Liyuan Rong, Huiliang Wen, Jun Yang, Jianhua Xie   +11 more
wiley   +1 more source

Atomic Model and Micelle Dynamics of QS-21 Saponin

Molecules, 2014
QS-21 is a saponin extracted from Quillaja saponaria, widely investigated as a vaccine immunoadjuvant. However, QS-21 use is mainly limited by its chemical instability, significant variety in molecular composition and low tolerance dose in mammals. Also,
Conrado Pedebos, Laércio Pol-Fachin, Ramon Pons, Cilâine V. Teixeira, Hugo Verli   +4 more
doaj   +1 more source

Mitigation of Rumen Methane Emissions with Foliage and Pods of Tropical Trees

Animals, 2020
Methane produced by enteric fermentation contributes to the emission of greenhouse gases (GHG) into the atmosphere. Methane is one of the GHG resulting from anthropogenic activities with the greater global warming contribution.
Jorge Canul-Solis, María Campos-Navarrete, Angel Piñeiro-Vázquez, Fernando Casanova-Lugo, Marcos Barros-Rodríguez, Alfonso Chay-Canul, José Cárdenas-Medina, Luis Castillo-Sánchez   +7 more
doaj   +1 more source

Targeting PLD3 Reverses the Immunosuppressive Niche by Reprogramming Tumor‐Associated Macrophages and Potentiates Antitumor Immunity

Advanced Science, EarlyView.
PLD3 activates the lysosomal‐AKT‐NF‐κB axis to drive cellular senescence in macrophages, establishing an immunosuppressive TME by limiting the infiltration of cytotoxic T, NK, and NKT cells, which confers resistance to anti‐PD‐1 therapy. Abrine inhibits PLD3 expression, restoring antitumor immunity and synergizing with anti‐PD‐1 treatment.
Xingtu Qin, Qiong Li, Xuemei Xu, Yuhan Wu, Yin Zhu, Jieqiong Wu, Yuan Fang, Qiubei Chen, Shuyang Wang, Jiang Yu, Yaping Ye, Hongli Jiao   +11 more
wiley   +1 more source