Results 61 to 70 of about 82,209 (307)

Non‐Canonical Function of DDX21 in Fetal Hematopoiesis Antagonizes KDM5A‐Mediated Repression of Ribosomal and Hematopoietic Genes

Advanced Science, EarlyView.
This study demonstrates a mechanism by which RNA helicase DDX21 coordinates the transcription of hematopoietic and ribosomal genes by interacting with the H3K4me3 demethylase KDM5A. The DDX21‐KDM5A complex co‐occupies active genes in hematopoietic progenitors, thereby ensuring their rapid proliferation during fetal hematopoiesis.
Adrian On‐Wah Leung, Chang Li, Xianyin Huang, Zhuming Fan, Yuning Chen, Jiaxing Liu, Hong Man Lin, Xiaoming Cui, Fujia Zhang, Ruoxi Niu, Kam Tong Leung, Boxian Huang, Hoi‐Hung Cheung   +12 more
wiley   +1 more source

Saponins and their role as vaccine adjuvant against coccidiosis in poultry [PDF]

Kafkas Universitesi Veteriner Fakültesi Dergisi
Coccidiosis, induced by various Eimeria species, has been one of the most important health threats and performance of poultry around the world. Other than the current treatment, successful vaccination approaches have been realized.
Abdullah F. ALSAYEQH
doaj   +1 more source

Triterpenoid Saponins

, 1988
Triterpenoid saponins isolated from various sources are reviewed. The recent techniques used in their isolation and structure elucidation are discussed.
Sarkar, Sudip K, Poddar, Gurudas, Gurudas Poddar, Mahato, Shashi B, Shashi B. Mahato, Sudip K. Sarkar   +5 more
core   +1 more source

Artificial Intelligence‐Driven Network Pharmacology: A Methodological Paradigm Shift Bridging Traditional Wisdom and Modern Science

Advanced Intelligent Discovery, EarlyView.
Artificial intelligence is redefining network pharmacology (NP). By integrating knowledge graph engineering, geometric deep learning, multiomics anchoring, and generative reasoning, AI‐driven NP (AI‐NP) transforms static target mapping into dynamic, predictive modeling.
Cong Wang, Sile Hu, Rigahai Ji, Riguna A, Siqige Hao, Ma Zhuo, Yi‐Hung Chen, Bisihalatu Hu, Ulana Bai, Xigui Hada   +9 more
wiley   +1 more source

Baihe Zhimu Decoction ameliorates anxious depression via PI3K/AKT/mTOR pathway‐mediated neuroprotection and inhibition of hippocampal neuronal apoptosis

Animal Models and Experimental Medicine, EarlyView.
Baihe Zhimu Decoction alleviates anxious depression‐like behaviors and protects hippocampal neurons. Chemical profiling and network pharmacology reveal multiple active components acting via the PI3K/AKT/mTOR pathway, enhancing neuronal survival and function, as confirmed by multi‐level in vitro and in vivo validation.
Yuanshan Han, Kexin He, Haolan Yang, Jiacheng Dai, Ronglin Chen, Yang Liu, Yuhong Wang, Lin Tang, Hongqing Zhao   +8 more
wiley   +1 more source

Bioactive compounds and antioxidant activity of wheat bran and barley husk in the extracts with different polarity

International Journal of Food Properties, 2019
Extracts of wheat bran and barley husk with solvents of different polarity were analyzed to determine the concentration of bioactive compounds (phytic acid, saponins, flavonoids, total phenolic compounds and phenolic profile) and their antioxidant ...
P. López-Perea, F. A. Guzmán-Ortiz, A. D. Román-Gutiérrez, J. Castro-Rosas, C. A. Gómez-Aldapa, M. L. Rodríguez-Marín, R. N. Falfán-Cortés, L. G. González-Olivares, J. G. Torruco-Uco   +8 more
doaj   +1 more source

Homo-aro-cholestane, furostane and spirostane saponins from the tubers of Ophiopogon japonicus

, 2017
Phytochemical investigation of the tubers of Ophiopogon japonicus led to the isolation of five previously undescribed steroidal saponins, ophiojaponins A-E, together with twelve known ones.
Liu, X, Wang, MK, Wang, MK (reprint author), Chengdu Univ, Sch Pharm & Bioengn, Chengdu 610106, Peoples R China., Wang, L, Khan, AA, Jiang, XL, Yu, K, Li, F, Zhang, WM   +8 more
core   +1 more source

Optimizing Electrode Design for Functional Activation of Human Pluripotent Stem Cell‐Derived Cardiomyocytes

Advanced NanoBiomed Research, EarlyView.
Electrical stimulation of human pluripotent stem cell‐derived cardiomyocytes is systematically investigated as a function of electrode material and configuration. Stimulation efficiency is found to be governed predominantly by electrode geometry, with increased electrode area and proximity to cells enabling more effective pacing.
Gustavo Ramirez‐Calderon, Abdulelah Saleh, Tania Cecilia Hidalgo Castillo, Anil Koklu, Adel Hama, Gabriel Herrera‐Lopez, Veronica Astro, Yazmin Hernández Mustafá, Plácido D. Jorge Collet, Lamia Bin Thuwaini, Pierre J. Magistretti, Antonio Adamo, Sahika Inal   +12 more
wiley   +1 more source

Saponins

, 2021
Includes bibliographical references and indexes.This 6 volume set presents a groundbreaking resource in this branch of natural organic compounds and demonstrates how proton nuclear magnetic resonance (NMR) spectroscopy can be manipulated in structures of
Yu Dequan, Qin Hailin
core  

Annatto‐Derived Carotenoids (Bixin and Norbixin) As Biodiesel Antioxidants: Characterization and Effects on Oxidative Stability (Rancimat and PetroOXY)

Journal of the American Oil Chemists' Society, EarlyView.
Annatto‐derived bixin and norbixin were characterized and evaluated as natural antioxidants for soybean biodiesel. Their antioxidant performance and effects on oxidative stability were assessed using DPPH, Rancimat, and PetroOXY methods. ABSTRACT The increasing use of eco‐friendly fuels is increasing the production of biodiesel but soybean biodiesel is
Marco Aurélio da Silva Coutinho, Edmilson Miranda de Moura, Carla Verônica Rodarte de Moura, Leanne Silva de Sousa, Vicente Galber Freitas Viana   +4 more
wiley   +1 more source