Results 141 to 150 of about 1,083 (177)
Prosaposin orchestrates a TGFβ1-driven paracrine loop between Schwann cells and gastric cancer to accelerate perineural invasion. [PDF]
Yang S +8 more
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Progranulin promotes glioma progression via interaction with cathepsin D and serves as a diagnostic and prognostic biomarker. [PDF]
Zhao C +9 more
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Broken Balance: Emerging Cross-Talk Between Proteostasis and Lipostasis in Neurodegenerative Diseases. [PDF]
Tittelmeier J, Nussbaum-Krammer C.
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Cross-Platform Transcriptomic Analysis of 40 Human and Rodent Skeletal Muscle Exerkines. [PDF]
Taha HB +5 more
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Nanodiscs for the study of membrane proteins. [PDF]
Denisov IG, Sligar SG.
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Characterization of Human Saposins by NMR Spectroscopy†
Biochemistry, 2006Saposins are lipid-binding and membrane-perturbing glycoproteins of the mammalian lysosomes involved in sphingolipid and membrane digestion. Although the four human saposins (Saps), A-D, are sequence-related, they are responsible for the activation of different steps in the cascade of lysosomal glycosphingolipid degradation. Saposin activity is maximal
Michael John +2 more
exaly +3 more sources
Saposins (sap) A and C activate the degradation of galactosylceramide in living cells
In loading tests using galactosylceramide which had been labelled with tritium in the ceramide moiety, living skin fibroblast lines derived from the original prosaposin-deficient patients had a markedly reduced capacity to degrade galactosylceramide. The
Klaus Harzer +2 more
exaly +2 more sources
Saposins A, B, C, and D in Plasma of Patients with Lysosomal Storage Disorders
BackgroundEarly diagnosis of lysosomal storage disorders (LSDs), before the onset of irreversible pathology, will be critical for maximum efficacy of many current and proposed therapies. To search for potential markers of LSDs, we measured saposins A, B,
Xiaoyang Qi +2 more
exaly +2 more sources
Saposins A, B, C, and D, which are required for the enzymatic hydrolysis of sphingolipids by specific lysosomal hydrolases, are produced by proteolytic processing of their common precursor protein, prosaposin.
Masao Hiraiwa +2 more
exaly +2 more sources

