Results 141 to 150 of about 1,083 (177)

Nanodiscs for the study of membrane proteins. [PDF]

open access: yesCurr Opin Struct Biol
Denisov IG, Sligar SG.
europepmc   +1 more source

Characterization of Human Saposins by NMR Spectroscopy†

Biochemistry, 2006
Saposins are lipid-binding and membrane-perturbing glycoproteins of the mammalian lysosomes involved in sphingolipid and membrane digestion. Although the four human saposins (Saps), A-D, are sequence-related, they are responsible for the activation of different steps in the cascade of lysosomal glycosphingolipid degradation. Saposin activity is maximal
Michael John   +2 more
exaly   +3 more sources

Saposins (sap) A and C activate the degradation of galactosylceramide in living cells

open access: yesFEBS Letters, 1997
In loading tests using galactosylceramide which had been labelled with tritium in the ceramide moiety, living skin fibroblast lines derived from the original prosaposin-deficient patients had a markedly reduced capacity to degrade galactosylceramide. The
Klaus Harzer   +2 more
exaly   +2 more sources

Saposins A, B, C, and D in Plasma of Patients with Lysosomal Storage Disorders

open access: yesClinical Chemistry, 2000
BackgroundEarly diagnosis of lysosomal storage disorders (LSDs), before the onset of irreversible pathology, will be critical for maximum efficacy of many current and proposed therapies. To search for potential markers of LSDs, we measured saposins A, B,
Xiaoyang Qi   +2 more
exaly   +2 more sources

Lysosomal Proteolysis of Prosaposin, the Precursor of Saposins (Sphingolipid Activator Proteins): Its Mechanism and Inhibition by Ganglioside

open access: yesArchives of Biochemistry and Biophysics, 1997
Saposins A, B, C, and D, which are required for the enzymatic hydrolysis of sphingolipids by specific lysosomal hydrolases, are produced by proteolytic processing of their common precursor protein, prosaposin.
Masao Hiraiwa   +2 more
exaly   +2 more sources

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