Results 121 to 130 of about 1,094 (157)
Tracking of Prosaposin, a Saposin Precursor, in Rat Testis [PDF]
Journal of Histochemistry & Cytochemistry, 2023 We tracked prosaposin (PSAP), a trophic factor, using an antibody specific to its proteolytic portion and an antibody to sortilin that traffics PSAP only to the lysosome. Immunostaining revealed that PSAP was distributed mainly on the basal side of seminiferous tubules, where many Sertoli cells and pachytene spermatocytes contained PSAP and its ...
Kimiko Yamamiya +8 more
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Characterization of Human Saposins by NMR Spectroscopyâ€
Biochemistry, 2006Saposins are lipid-binding and membrane-perturbing glycoproteins of the mammalian lysosomes involved in sphingolipid and membrane digestion. Although the four human saposins (Saps), A-D, are sequence-related, they are responsible for the activation of different steps in the cascade of lysosomal glycosphingolipid degradation. Saposin activity is maximal
Michael John +2 more
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Saposins (sap) A and C activate the degradation of galactosylceramide in living cells [PDF]
FEBS Letters, 1997 In loading tests using galactosylceramide which had been labelled with tritium in the ceramide moiety, living skin fibroblast lines derived from the original prosaposin-deficient patients had a markedly reduced capacity to degrade galactosylceramide. The
Thierry Levade +2 more
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Saposins A, B, C, and D in Plasma of Patients with Lysosomal Storage Disorders
Clinical Chemistry, 2000 BackgroundEarly diagnosis of lysosomal storage disorders (LSDs), before the onset of irreversible pathology, will be critical for maximum efficacy of many current and proposed therapies. To search for potential markers of LSDs, we measured saposins A, B,
Peter Meikle +2 more
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Archives of Biochemistry and Biophysics, 1997 Saposins A, B, C, and D, which are required for the enzymatic hydrolysis of sphingolipids by specific lysosomal hydrolases, are produced by proteolytic processing of their common precursor protein, prosaposin.
Shoji Tsuji +2 more
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Crystal Structures of Human Saposins C and D: Implications for Lipid Recognition and Membrane Interactions [PDF]
Structure, 2008 SummaryHuman saposins are essential proteins required for degradation of sphingolipids and lipid antigen presentation. Despite the conserved structural organization of saposins, their distinct modes of interaction with biological membranes are not fully ...
Maxim Rossmann +2 more
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Combined saposin deficiency: A rare occurrence
Medical Journal Armed Forces India, 2023Combined saposin deficiency (OMIM #611721), an exceedingly rare lysosomal storage disorder, is caused by a mutation in the gene PSAP. This gene encodes a protein, prosaposin, that cleaves into four constituent proteins, each of which has a role as a cofactor for the enzymes whose deficiency results in Krabbe disease, metachromatic leukodystrophy ...
Vivek Bhat +3 more
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Saposins and Their Interaction with Lipids
Neurochemical Research, 1999The lysosomal degradation of several sphingolipids requires the presence of four small glycoproteins called saposins, generated by proteolytic processing of a common precursor, prosaposin. Saposins share several structural properties, including six similarly located cysteines forming three disulfide bridges with the same cysteine pairings.
A M, Vaccaro +3 more
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